Search results for "PRR"
showing 10 items of 26 documents
Benign familial infantile epilepsy associated with KCNQ3 mutation: a rare occurrence or an underestimated event?
2020
Abstract Benign familial infantile epilepsy (BFIE) is the most genetically heterogeneous phenotype among early-onset familial infantile epilepsies. It has an autosomal dominant inheritance pattern with incomplete penetrance. Although PRRT2 is the most mutated gene detected in families with BFIE, other mutations in KCNQ2, SCN2A, and GABRA6 genes have also been described. To date, KCNQ3 mutations have been detected in only four patients with BFIE. Here, we describe the clinical pattern and course of an additional individual with BFIE associated with a novel missense heterozygous KCNQ3 c.1850G>C variant inherited by his unaffected father. The incidence of KCNQ3 mutations among BFIE patients…
Therapeutic sequences in patients with grade 1−2 neuroendocrine tumors (NET): an observational multicenter study from the ELIOS group
2019
Purpose: Many different treatments are suggested by guidelines to treat grade 1−2 (G1−G2) neuroendocrine tumors (NET). However, a precise therapeutic algorithm has not yet been established. This study aims at identifying and comparing the main therapeutic sequences in G1−G2 NET. Methods: A retrospective observational Italian multicenter study was designed to collect data on therapeutic sequences in NET. Median progression-free survival (PFS) was compared between therapeutic sequences, as well as the number and grade of side effects and the rate of dose reduction/treatment discontinuation. Results: Among 1182 patients with neuroendocrine neoplasia included in the ELIOS database, 131 G1–G2 ga…
Il Piano nazionale di ripresa e resilienza e le sue fonti: dinamiche dei processi normativi in tempo di crisi
2022
Il libro descrive ed opera un'analisi critica del quadro normativo Euro-nazionale nell'ambito del quale è stato definito il Piano nazionale di ripresa e resilienza italiano (PNRR). Oggetto principale dell'analisi è l'impatto del quadro normativo UE nell'ambito del quale è stato sviluppato Next Generation EU ed, in particolare, il Dispositivo sulla ripresa e la resilienza, sul sistema delle fonti che caratterizza l'ordinamento costituzionale italiano. Sono prese in esame, in particolare le "misure legislative" previste dal piano, il sistema di indicatori di valutazione delle stesse per verificare se è stata data "soddisfacente" attuazione al Piano e le prassi attuative. The book gives an ove…
I più recenti sviluppi costituzionali del ciclo di bilancio
2023
The A. answer to a series of questions by the Director of the "Gruppo di Pisa" Journal. The questions concern the parliamentary procedure followed to enact the State Budget Law for the year 2023 (law No 197/2022). The A. debates over: the possibility to prove the evident violation of parliamentary privileges in the procedure followed by the two chambers of the Italian parliament (Const. court. orders Nos. 17/2019 and 60/2020); the impact of Next Generation EU and of NPRR over the National Budgetary procedures; the role played by the Budget Parliamentary Office (UPB) and by the State General Accounting Office in parliamentary procedures concerning the State Budget Law for the year 2023
Identification et caractérisation du récepteur à la flagelline (VvFLS2) et recherche du récepteur aux chito-oligosaccharides chez la vigne
2014
Pattern-recognition receptors (PRRs) play a key role in plant immunity by assuring recognition of microbe-associated molecular patterns (MAMPs), signature of microbial presence. MAMP perception constitutes the first layer of pathogen detection and activates defense mechanisms that aim to block the intruder. This study brings an insight into how grapevine (Vitis vinifera) perceives two MAMPs: the flagellin-derived flg22 peptide and chitin, which are conserved motifs occurring over the whole bacterial and fungal classes, respectively. This study analyzed MAMP-triggered early signaling events, defense gene expression and also the efficiency of elicited defense against gray mold and downy milde…
Identification of the VvFLS2 grapevine flagellin receptor by a functional genomics strategy
2013
National audience; Grapevine (Vitis vinifera) is a crop of high agronomic interest subject to many destructive diseases. Pattern recognition receptors (PRRs) mediate detection of potential pathogens via the perception of pathogen associated molecular patterns (PAMPs), which is important for plant disease resistance. A well studied PRR is the Arabidopsis leucine-rich repeat receptor kinase FLS2 that recognizes bacterial flagellin (or its minimal motif flg22). Flagellin perception plays an important role in restricting bacterial invasion into plant leaves. Until now, functional FLS2 orthologues have been characterized in Nicotiana benthamiana, rice and tomato. Despite its economical importanc…
Comment stimuler l’immunité de la vigne avec des éliciteurs
2013
Induced resistance in grapevine : from concept to vineyard application
2012
International audience
Induced resistance in grapevine: from concept to vineyard application
2012
SPE IPM Chapitre 11; International audience
Etude du système de perception des chito--oligosaccharides chez la vigne et rôle dans l'immunité.
2014
Rapport de stage Master II R SPE IPM; Master