Search results for "PRR"
showing 6 items of 26 documents
Penicillium lanoso-viride AMP dezamināzi atpazīstošo receptoru klāsta detektēšana perifēro asiņu mononukleārajās šūnās
2016
Šajā darbā salīdzināta Penicillium lanoso-viride sintezētās AMPD un citu sēņu izcelsmes imūnmodulatoru un standartvielu iedarbība uz iekaisuma reakcijās iesaistītu molekulu gēnu ekspresiju un sekrēciju asins imūnsistēmas šūnās, un, balstoties uz rezultātos iegūto informāciju, veikta AMPD atpazīstošo PRR analīze. Ar RT-PCR metodi veiktās analīzes uzrāda, ka AMPD stimulētās asins imūnajās šūnās ir paaugstināta iekaisuma citokīnu, kā arī TLR4 signālceļā iesaistīto molekulu gēnu ekspresija, kas norāda uz tās iekaisumu veicinošo ietekmi. Ar receptoru bloķēšanas un ELISA proteīnu koncentrācijas noteikšanas metodes palīdzību noskaidrots, ka AMPD savu imūnmodulatoro darbību asins mononukleārajās šū…
La riflessività nel percorso formativo dei formatori
2012
The grapevine LysM receptor-like kinase VvLYK5-1 mediates chitin-triggered immunity
2021
The establishment of defense reactions to protect plants against invading pathogens first requiresthe recognition of Microbe-Associated Molecular Patterns (MAMPs), detected by plasmamembrane-bound Pattern Recognition Receptors (PRRs). These MAMPs, also termed elicitors, areused in several biocontrol products that are gradually developing to reduce the use of chemicalpesticides in agriculture. Chitin, the main component of fungal cell walls, as well as its deacetylatedderivative, chitosan, are two chitooligosaccharides (COS) that can be found in some of theseproducts. Unfortunately, the mechanism allowing the perception of these molecules is still poorlyunderstood in Vitis vinifera, sometime…
Identification and characterization of the grapevine flagellin receptor vvfls2
2014
International audience
[177Lu]Lu-DOTA-TATE and [131I]MIBG Phenotypic Imaging-Based Therapy in Metastatic/Inoperable Pheochromocytomas and Paragangliomas: Comparative Result…
2022
PurposeThe aim of the study is to assess phenotypic imaging patterns and the response to treatment with [177Lu]Lu-DOTA-TATE and/or [131I]MIBG in paragangliomas (PGLs) and pheochromocytomas (PHEOs), globally and according to the primary location.MethodsThis is a 17-patient retrospective observational study, with 9 cases treated with [177Lu]Lu-DOTA-TATE and 8 with [131I]MIBG (37 total treatments). Functional imaging scans and treatment responses were studied in order to choose the best therapeutic option and to define the progression-free survival (PFS) and disease control rate (DCR) according to treatment modality and primary location.ResultsAll patients were studied with phenotypic nuclear …
Perception of pathogenic or beneficial bacteria and their evasion of host immunity: pattern recognition receptors in the frontline
2015
International audience; Plants are continuously monitoring the presence of microorganisms to establish an adapted response. Plants commonly use pattern recognition receptors (PRRs) to perceive microbe- or pathogen-associated molecular patterns (MAMPs/PAMPs) which are microorganism molecular signatures. Located at the plant plasma membrane, the PRRs are generally receptor-like kinases (RLKs) or receptor-like proteins (RLPs). MAMP detection will lead to the establishment of a plant defense program called MAMP-triggered immunity (MTI). In this review, we overview the RLKs and RLPs that assure early recognition and control of pathogenic or beneficial bacteria. We also highlight the crucial func…