Search results for "PSM"

showing 10 items of 70 documents

Recommendations of the treatment-resistant depression expert center network for promoting tobacco smoking cessation based on the results from the rea…

2022

Abstract Background Tobacco smoking has been associated with suicide, impulsivity and depression in non-clinical populations with differences across sexes. Objective To determine the role of tobacco smoking in Treatment-Resistant Depression (TRD) according to sex in a precision-medicine approach. Method The FACE-TRD cohort is a national cohort of TRD patients recruited in 13 resistant depression expert centers between 2014 and 2021 and followed-up at 6 months. A standardized one-day long comprehensive battery was carried out, including trained-clinician and patient-reported outcomes, and patients were reevaluated at 6 months on their smoking and psychiatric hospitalization outcomes. Results…

Malemedicine.medical_treatmentMESH: Tobacco SmokingSuicide AttemptedtobaccoMESH: NicotineCohort StudiesDepressive Disorder Treatment-Resistantchemistry.chemical_compoundSurveys and QuestionnairesMedicinePrecision MedicineVareniclineMESH: Cohort StudiesDepression (differential diagnoses)health care economics and organizationseducation.field_of_studypublic mental healthMESH: Middle AgedMESH: Suicidal Ideationpublic healthMiddle AgedMESH: Smoking CessationpsychiatryCohortdepressionMESH: Suicide AttemptedFemalemental healthNicotinemedicine.medical_specialtyPopulationeducationMESH: Precision MedicinesmokingSuicidal IdeationMESH: Depressive Disorder Treatment-ResistantSex FactorsMESH: Sex FactorsTobacco SmokingHumansMESH: Surveys and QuestionnaireseducationPsychiatryBiological PsychiatryPharmacologyMESH: HumansSuicide attemptbusiness.industryOdds ratiomedicine.diseaseMESH: Maleschizophreniachemistry[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental healthSmoking cessationSmoking CessationbusinessTreatment-resistant depressionMESH: Female
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The Independent Effects of Psychosocial Stressors on Subclinical Psychosis: Findings from the Multinational EU-GEI Study

2021

The influence of psychosocial stressors on psychosis risk has usually been studied in isolation and after the onset of the disorder, potentially ignoring important confounding relationships or the fact that some stressors that may be the consequence of the disorder rather than preexisting. The study of subclinical psychosis could help to address some of these issues. In this study, we investigated whether there was (i) an association between dimensions of subclinical psychosis and several psychosocial stressors including: childhood trauma, self-reported discrimination experiences, low social capital, and stressful life experiences, and (ii) any evidence of environment-environment (ExE) inte…

Malestressful life eventsSchizotypypositive subclinical symptomEthnic groupSocial Environmentsubclinical psychosispositive subclinical symptoms0302 clinical medicineAdverse Childhood ExperiencesSettore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat.SINTOMAS PSÍQUICOSsubclinical psychosi10. No inequalityCOMMUNITY ASSESSMENTSubclinical infectionGENERAL-POPULATIONpsychotic symptomDepressionConfoundingSocial Discriminationdepressive subclinical symptomstressful life eventETHNIC-GROUPS3. Good healthPsychiatry and Mental healthNEIGHBORHOOD CHARACTERISTICSADULT PSYCHIATRIC-DISORDERSpsychotic symptomsAdverse Childhood ExperienceFemalepsychosocial stressPsychologyPsychosocialHumanClinical psychologynegative subclinical symptompsychosocial streAdultPsychosisSiblingLIFE EVENTSschizotypyPsychotic Disorder03 medical and health sciencesCommunity Assessment of Psychic Experiences (CAPE)THREATENING EXPERIENCESmedicineHumansEuropean UnionSiblingSettore MED/25 - Psichiatriachildhood traumaSiblingsStressormedicine.diseasePERCEIVED DISCRIMINATIONnegative subclinical symptoms030227 psychiatryPSYCHOMETRIC PROPERTIESPsychotic Disorders[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental healthdis criminationsocial capitaldepressive subclinical symptomsStress Psychological030217 neurology & neurosurgeryRegular Articlesdiscrimination
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Rapid evaluation of notch stress intensity factors using the peak stress method: Comparison of commercial finite element codes for a range of mesh pa…

2018

The peak stress method (PSM) is an engineering, finite element (FE)-oriented method to rapidly estimate the notch stress intensity factors by using the singular linear elastic peak stresses calculated from coarse FE analyses. The average element size adopted to generate the mesh pattern can be chosen arbitrarily within a given range. Originally, the PSM has been calibrated under pure mode I and pure mode II loadings by means of Ansys FE software. In the present contribution, a round robin between 10 Italian universities has been carried out to calibrate the PSM with 7 different commercial FE codes. To this aim, several two-dimensional mode I and mode II problems have been analysed independe…

Materials sciencefinite element (FE) analysinotch stress intensity factor (NSIF)02 engineering and technologyStress (mechanics)Settore ING-IND/14 - Progettazione Meccanica E Costruzione Di Macchine0203 mechanical engineeringFinite Element Analysis (FEA)Range (statistics)Mechanics of MaterialGeneral Materials Sciencecoarse mesh finite element (FE) analysis notch stress intensity factor (NSIF) peak stress method (PSM)Stress intensity factorMechanical Engineeringpeak stress method (PSM)Coarse mesh Finite Element Analysis (FEA) Notch Stress Intensity Factor (NSIF) Peak Stress Method (PSM)Coarse meshMechanicsfinite element (FE) analysis021001 nanoscience & nanotechnologyFinite element methodcoarse mesh; finite element (FE) analysis; notch stress intensity factor (NSIF); peak stress method (PSM);020303 mechanical engineering & transportsMethod comparisonCorse mesh finite element analysis peak stress method notch stress intensity factors.Mechanics of Materialscoarse mesh; finite element (FE) analysis; notch stress intensity factor (NSIF); peak stress method (PSM)Materials Science (all)coarse mesh0210 nano-technology
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Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

2020

AbstractEating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa (BN) and problem alcohol use (genetic correlation [rg], twin-based=0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge-eating, AN without binge-eating, and a BN factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], …

Netherlands Twin Register (NTR)Alcoholism/geneticsSchizophrenia/genetics[SDV]Life Sciences [q-bio][SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental healthMedizinMedicine (miscellaneous)Genome-wide association studyAlcohol use disorderAnorexia nervosaLinkage Disequilibriumddc:616.89[SCCO]Cognitive science0302 clinical medicineRisk FactorsTobacco Use Disorder/geneticsSubstance-Related Disorders/genetics0303 health sciences[SDV.MHEP] Life Sciences [q-bio]/Human health and pathologyFactors de risc en les malaltiesBulimia nervosaFeeding and Eating Disorders/geneticseating disorders; genetic correlation; substance useTobacco Use Disordergenetic correlation3. Good healthFenotip[SDV] Life Sciences [q-bio]Psychiatry and Mental healthAlcoholismEating disordersPhenotypeSchizophreniaDrinking of alcoholic beverageseating disorderConsum d'alcoholMajor depressive disorder/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingmedicine.symptomDepressive Disorder Major/geneticseating disorders genetic correlation substance useClinical psychologySubstance abuseRisk factors in diseasesSubstance-Related Disorderssubstance useeating disordersPolymorphism Single NucleotideArticleFeeding and Eating Disorders03 medical and health sciencesSDG 3 - Good Health and Well-beingmental disorders/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_GeneticsmedicineHumansTrastorns de la conducta alimentària030304 developmental biologyGenetic associationPharmacologyeating disorders ; genetic correlation ; substance useDepressive Disorder MajorBinge eatingbusiness.industry[SCCO.NEUR]Cognitive science/Neuroscience[SCCO.NEUR] Cognitive science/Neurosciencesubstance use.[SCCO] Cognitive sciencemedicine.diseaseComorbidityTwin study030227 psychiatryAbús de substàncies[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental healthSchizophreniabusinessGenètica030217 neurology & neurosurgery[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyGenome-Wide Association Study
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Diagnostic efficacy of Gallium-68-PSMA PET/CT in 565 patients with biochemical recurrence of prostate cancer

2019

OncologyBiochemical recurrencemedicine.medical_specialtyProstate cancerchemistrybusiness.industryInternal medicineMedicinechemistry.chemical_elementGalliumbusinessmedicine.diseasePsma pet ct57. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin
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Clinical Translation and First In-Human Use of [44Sc]Sc-PSMA-617 for PET Imaging of Metastasized Castrate-Resistant Prostate Cancer

2017

Background: Various trivalent radiometals are well suited for labeling of DOTA-conjugated variants of Glu-ureido-based prostate-specific membrane antigen (PSMA) inhibitors. The DOTA-conjugate PSMA-617 has proven high potential in PSMA radioligand therapy (PSMA-RLT) of prostate cancer as well as PET imaging when labeled with lutetium-177 and gallium-68 respectively. Considering the relatively short physical half-life of gallium-68 this positron emitter precludes prolonged acquisition periods, as required for pre-therapeutic dosimetry or intraoperative applications. In this context, the positron emitter scandium-44 is an attractive alternative for PET imaging. We report the synthesis of [44Sc…

OncologyMalemedicine.medical_specialtytheranostics.Medicine (miscellaneous)Context (language use)SpleenGallium RadioisotopesLutetiumurologic and male genital diseases030218 nuclear medicine & medical imaging03 medical and health sciencesProstate cancerHeterocyclic Compounds 1-Ring0302 clinical medicineInternal medicinePositron Emission Tomography Computed TomographyLNCaPmedicineDosimetryHumansRadiometryPharmacology Toxicology and Pharmaceutics (miscellaneous)AgedRadioisotopesUrinary bladderChemistrybusiness.industryDipeptidesProstate-Specific Antigenmedicine.diseaseprostate cancerPSMA-617scandium-44Small intestineProstatic Neoplasms Castration-Resistantmedicine.anatomical_structurePET030220 oncology & carcinogenesisAbsorbed doseRadiopharmaceuticalsNuclear medicinebusinessScandiumResearch PaperHalf-LifeTheranostics
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Reply: “The Impact of 68Ga-PSMA PET/CT and PET/MRI on the Management of Prostate Cancer”

2019

PET-CTmedicine.diagnostic_testbusiness.industryUrology68ga psmaMagnetic resonance imagingPet imagingManagement of prostate cancerPositron emission tomographymedicineHaloNuclear medicinebusinessScatter correctionUrology
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[Atrial fibrillation in patients with COVID-19. Usefulness of the CHA

2021

Resumen Introduccion y objetivos La enfermedad por coronavirus de 2019 (COVID-19) esta causada por el segundo coronavirus del sindrome respiratorio agudo y grave. La fibrilacion auricular (FA) es comun en situaciones agudas, en las que conlleva mas complicaciones y mortalidad. Metodos Analisis del Registro internacional HOPE (NCT04334291); el objetivo es evaluar la informacion pronostica de FA en pacientes con COVID-19. Se realizo un analisis multivariable y un emparejamiento por puntuacion de propension para evaluar la relacion entre FA y mortalidad. Ademas, se evaluo en estos pacientes el impacto en la mortalidad y los eventos embolicos de la puntuacion CHA2DS2-VASc. Resultados Entre los …

PSM propensity score matchingRegistrymedicine.medical_specialtyAF atrial fibrillationArtículo Original030204 cardiovascular system & hematologyRisk AssessmentFibrilación auricular03 medical and health sciences0302 clinical medicinePredictive Value of TestsRisk FactorsHemorragiaInternal medicineHumansMedicineRegistriesMortalityStrokeEPP emparejamiento por puntuación de propensiónSARS-CoV-2business.industryIncidence (epidemiology)Mortality rateBleedingHazard ratioPronósticoCOVID-19Atrial fibrillationGeneral MedicinePrognosismedicine.diseaseAtrial fibrillationStrokeFA fibrilación auricularCHA2DS2-VAScPredictive value of testsMortalidadPropensity score matchingOriginal ArticleRegistroCardiology and Cardiovascular MedicinebusinessRisk assessmentHumanitiesRevista espanola de cardiologia
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PSMA6 gēna promotera poliadenozīna trakta polimorfismu asociācija ar bronhiālo astmu, aptaukošanos un 1. tipa cukura diabētu Latvijas populācijā

2015

Ubikitīna – proteasomu sistēma ir multienzīmatisks proteāžu komplekss, kas regule dažādus šūnu procesus. Šis sistēmas disregulācija var būt iesaistīta tādos cilvēka patoloģiju rašanās mehanismos kā 2. tipa cukura diabēts, juvenīlais idiopātiskais artrīts un Greivsa slimība. Tas var būt atkarīgs no proteasomas gēnu strukturālām pārmaiņām, kuri kodē proteasomu apakšvienības. Šajā pētījumā mēs analizējam asociāciju starp PSMA6 gēna promotera poly(A) (c. –655 An) mikrosatelīta garuma izmaiņām un bronhiālo astmu (BA), 1. tipa cukura diabētu (T1DM) un aptaukošanos (APT) Latvijas populācijā. PSMA6 gēna poly(A) polimorfisms tika analizēts ar gadījuma / kontroles pētījumu un bioinformātiskām program…

PSMA6 gēnsproteasomaspromotersnukleosomu organizācijaMedicīnapoly(A) mikrosatelīts
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In vitro vēža šūnu modeļsistēmas izstrāde molekulāri mērķētu radionuklīdu testēšanai

2019

Prostatas vēzis ir ceturtais biežāk diagnosticētais vēzis Eiropā, 2018. gadā un tas ir kļuvis par visbiežāk sastopamo vēzi vīriešu vidū. Nozīmīgi klīnisko pētījumu rezultāti prostatas vēža diagnostikā un terapijā ir sasniegti ar radioaktīvi iezīmētu PSMA ligandu 68Ga-PSMA – diagnostikai un 177Lu-PSMA – terapijai. Neiroendokrīnie audzēji ir neviendabīga agresīvu audzēju grupa, kam raksturīgi dažādi un bieži nespecifiski simptomi, kas apgrūtina precīzu audzēja primāro diagnostiku un saslimšanas stadijas precizēšanu. Pašlaik šo audzēju diagnostikā un ārstēšanā izmanto ar SSTR2 ligandiem (somatostatīna analogiem) konjugētus radionuklīdus. Šī darba mērķis bija izveidot uz dažādām šūnu līnijām ba…

Prostatas vēzisSSTR2 un PSMAin vitro modeļsistēmaBioloģija68Ga un 177Lu radionuklīdineiroendokrīnais vēzis
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