Search results for "PSO."

2015. 2. Por qué celebrar primarias

2015

¿Por qué celebrar primarias? ¿Beneficia o perjudica a las organizaciones y partidos que las promueven?, ¿Mejora la participación?, ¿La elección de los dirigentes evita la oligarquización y la Ley de Hierro de los partidos políticos que enunció Robert Michels? Un sistema de selección de candidatos con origen en la política norteamericana, fue adaptado por el PSOE, y a continuación iría extendiéndose su práctica a los todos los partidos políticos. Ignacio Urquizu señalaba sobre las elecciones primarias, en 2013 que: «Esta experiencia se ha repetido en España en 13 ocasiones más, aunque sólo en el ámbito regional. Únicamente en una ocasión las utilizó el PP y fue en las últimas elecciones auto…

Structural and functional diversity of the lectin repertoire in teleost fish: Relevance to innate and adaptive immunity

2011

Protein–carbohydrate interactions mediated by lectins have been recognized as key components of innate immunity in vertebrates and invertebrates, not only for recognition of potential pathogens, but also for participating in downstream effector functions, such as their agglutination, immobilization, and complement-mediated opsonization and killing. More recently, lectins have been identified as critical regulators of mammalian adaptive immune responses. Fish are endowed with virtually all components of the mammalian adaptive immunity, and are equipped with a complex lectin repertoire. In this review, we discuss evidence suggesting that: (a) lectin repertoires in teleost fish are highly dive…

Traditional medicine as a source of new therapeutic agents against psoriasis.

2000

In the frame of traditional medicine, the use in the treatment of psoriasis of some plants typical of the flora of Sicily is reported. A preliminary search on some plants used for the treatment of psoriasis in Asia, South America and Africa is also reported.

Optical sensing responses of CrIIICl(TPP)(H2O)-based coatings obtained by an atmospheric pressure plasma method – Application to the detection of vol…

2014

Food spoilage processes are a considerable concern for both the food industry and the consumer, due to financial, food quality and food safety aspects. A primary issue is the prevention/monitoring of the formation of biogenic and volatile amines, such as occurring in fish and in other microbiologically unstable food items rich in proteins, produced by e.g. oxidative decarboxylation of amino acids. One strategy for their monitoring is the development of films with colorimetric sensing properties that are able to indicate food spoilage. The aim of this investigation was the development of a novel metalloporphyrin-based coating allowing the sensitive detection of typical volatile amines, such …

Presystemic metabolism and intestinal absorption of antipsoriatic fumaric acid esters.

2003

Psoriasis is a chronic inflammatory skin disease. Its treatment is based on the inhibition of proliferation of epidermal cells and interference in the inflammatory process. A new systemic antipsoriasis drug, which consists of dimethylfumarate and ethylhydrogenfumarate in the form of their calcium, magnesium and zinc salts has been introduced in Europe with successful results. In the present study, a homologous series of mono- and diesters of fumaric acid has been studied with respect to the sites and kinetics of presystemic ester degradation using pancreas extract, intestinal perfusate, intestinal homogenate and liver S9 fraction. In addition, intestinal permeability has been determined usi…

Simulation of the dynamics of hard ellipsoids

2008

We study a system of uniaxial hard ellipsoids by molecular dynamics simulations, changing both the aspect-ratio X-0 (X-0 = a/b, where a is the length of the revolution axis and b is the length of the two other axes) and the packing fraction phi. We calculate the translational and rotational mean squared displacements, the translational D-trans and the rotational D-rot diffusion coefficients and the associated isodiffusivity lines in the phi - X-0 plane. For the first time, we characterize the cage effect through the logarithmic time derivative of log and log . These quantities exhibit a minimum if the system is supercooled and we show that, consistently with our previous findings, for large…

Foliations making a constant angle with principal directions on ellipsoids

2015

1984. Materiales del 30 Congreso Federal del PSOE. Madrid 13-16 diciembre 1984

2014

Recopilé el presente material del 30 Congreso Federal del PSOE, celebrado en Madrid el 13-16 diciembre 1984, al que asistí como observador, como base de mi investigación sobre la historia del socialismo [PSOE y PSPV-PSOE]. Aquí se recogen varias publicaciones editadas con motivo del XXX congreso, así como documentos orgánicos del PSOE [Resoluciones, reglamentos, Estatutos, etc.], para que puedan ser útiles a estudiantes, investigadores, y personas interesadas en el tema. Parte de esta documentación ha servido para elaborar el capítulo "El IV congreso del PSPV-PSOE. Alicante, 19, 20 y 21 de abril de 1985. Seguim treballant pel canvi". Contiene los siguientes documentos: 1.- PSOE 1981-1984. D…

Polycystin-1 downregulation induces ERK-dependent mTOR pathway activation in a cellular model of psoriasis

2018

Psoriatic plaques tend to localize to the knees and elbows, areas that are particularly subject to mechanical stress resulting from bending and friction. Moreover, plaques often develop at sites of mechanical trauma or injury (Koebner phenomenon). Nevertheless, mechanotransduction has never been linked to psoriasis. Polycystins (polycystin-1, PC1; polycystin-2, PC2) are mechanosensitive molecules that function as key regulators of cellular mechanosensitivity and mechanotransduction. The aim of this in vitro study was to investigate the role of polycystins in the development of psoriasis. We showed that PC1 knockdown in HaCaT cells led to an elevated mRNA expression of psoriasis-related biom…

On the genetics of psoriasis

1974

To elucidate the mode of inheritance in psoriasis, Falconer's model for estimating heritability which is under the assumption of multifactorial inheritance, was applied to the data of Hellgren (1967) from Sweden. The heritability estimates were based on both manifest and potential psoriasis since a clear separation of these two categories was impossible. These estimates were 64% for parents, 60% for siblings and 52% for all first degree relatives which included the children of psoriatic cases. For second degree relatives it was 48%. None of these differences are statistically significant. The results are discussed.