Search results for "PSO"

Adenosine A2A and A2B Receptors Differentially Modulate Keratinocyte Proliferation: Possible Deregulation in Psoriatic Epidermis

2017

Adenosine is a potent regulator of inflammation and immunity, but the role of adenosine receptors in keratinocytes remains controversial. We determined that in addition to A2B receptors, human epidermal keratinocytes also express A2A receptors, although to a lower extent. Through the use of selective adenosine receptor agonists and antagonists, we showed that physiological concentrations of adenosine activate A2B receptors in normal human keratinocytes, inducing cell cycle arrest through the increase of intracellular calcium but not through cAMP signaling. In contrast, the selective activation of A2A receptors by CGS-21680 induces keratinocyte proliferation via p38–mitogen-activated protein…

Psychosocial Work Factors, Job Stress and Strain at the Wheel: Validation of the Copenhagen Psychosocial Questionnaire (COPSOQ) in Professional Drive…

2019

Introduction: Psychosocial work environment has been related to many negative health outcomes in different workforces. However, evidence in this regard is still limited in the case of transport workers, and most of the tools used in research, often excessively generic, do not fully consider the specific key stressors and adverse issues present in the psychosocial environment of professional driving. Objective: Thus, the purpose of this study was to obtain a complete description of the validation of measurement applied to psychosocial factors at work in professional drivers, using the Enterprise version (2018) of COPSOQ-III. Methods: The data was collected from 726 Spanish professional drive…

Multi-elemental EDXRF mapping of polluted soil from former horticultural land.

2004

The distribution of major and trace elements was systematically investigated by use of energy dispersive X-ray fluorescence spectrometry (EDXRF) on a former horticultural soil. The purpose of the study was to combine mapping of soil element concentration levels with multivariate statistics for characterisation of soil metal pollution in relation to previous and present land use. A 1-ha study site was chosen from a former horticulture where a previous preliminary survey indicated increased concentration levels of toxic elements. The soil was sampled from the top 20 cm of the soil surface in a 10×10-m grid-like pattern covering the 1-ha study area. In addition, three soil profiles were studie…

Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview

2021

Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19) and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced by macrophages and dendritic cells, in response to exogenous or endogenous signals, and drives the differentiation and activation of T helper 17 (Th17) cells with subsequent production of IL-17A, IL-17F, IL-6, IL-22, and tumor necrosis factor α (TNF-α). Although IL-23 plays a pivotal role in the protective immune response to bacterial and fungal infections, its dysregulation has been shown to exacerbate chronic immune-mediated inflammation. Well-established experimental data support the concept that IL-23/IL…

Defective Induction of COX-2 Expression by Psoriatic Fibroblasts Promotes Pro-inflammatory Activation of Macrophages

2019

Fibroblasts play an important role as members of the innate immune system through the secretion of COX-2-derived inflammatory mediators such as prostaglandin E-2 (PGE(2)). However, it has been described that dermal fibroblasts behave like mesenchymal stem cells reducing lymphocyte recruitment and dendritic cell activation through PGE(2) release. As the role of fibroblasts in psoriasis remains poorly characterized, in the present study we have evaluated the possible influence of PGE(2) derived from dermal fibroblasts as modulator of the immune response in psoriatic skin. Our results indicate that under inflammatory conditions, psoriatic fibroblasts showed defective induction of COX-2, which …

Las elecciones de 9 de marzo de 2008 en España

2008

Este artículo describe con detalle las elecciones generales de 2008 en España. Su interés no sólo está en la exhaustiva presentación de los datos, sino también en el punto de vista de la propia autora: se trata de análisis de la política española realizado desde Italia. La posición del observador facilita un relato más aséptico de los acontecimientos que dan cuenta de los comicios en los que, por segunda vez consecutiva, Zapatero fue el más votado. En el texto podemos comparar las estrategias electorales de los dos grandes partidos (PSOE y PP), sus diferencias programáticas y el contexto sociopolítico español, desgraciadamente marcado por la violencia terrorista.

Desarrollo de formulaciones de liberación controlada para enfermedades inflamatorias

2022

Las enfermedades inflamatorias con componente autoinmune de la piel y del tracto gastrointestinal, como son la psoriasis y la dermatitis atópica y la enfermedad inflamatoria intestinal, respectivamente, son enfermedades prevalentes que necesitan mejorar su tratamiento. La ciclosporina A es un fármaco inmunosupresor que ha demostrado ser efectivo para el tratamiento de enfermedades autoinmunes, pero también sus efectos adversos a nivel sistémico. En el caso de las enfermedades cutáneas, la administración por vía tópica de este fármaco aportaría grandes ventajas como la posibilidad de actuar a nivel local y evitar efectos sistémicos. Sin embargo, la ciclosporina A presenta un tamaño molecular…

Some aspects of group actions on manifolds

2021

Aptiekā piedāvāto psoriāzes alternatīvas terapijas preparātu sastāva pētījums

2019

Psoriāze ir nopietna un izplatīta hroniska ādas slimība. Ar to slimo dažāda vecuma cilvēki. Šī slimība nav izārstējama, bet var mazināt tās simptomus, pielietojot lokālu vai sistēmisku terapiju. Psoriāze ir sociāla problēma, kas skar apmēram 100 miljonus cilvēku visā pasaulē. Darba mērķis ir izpētīt psoriāzes terapijai pieejamo alternatīvu sastāvu un salīdzināt to ražotāju rekomendācijas ar zinātniskajā literatūrā pieejamo informāciju. Ar anketēšanas palīdzību tika noteikti psoriāzes pacientu viedokļi par bezrecepšu medikamentu lietošanu psoriāzes simptomu mazināšanai. No piedāvātajiem bezrecepšu medikamentiem psoriāzes simptomu ārstēšanai tika apskatīti „Dermalex Psoriasis”, „Psoriaten zie…

Psoriāzi ārstējošo zāļu aprite vairākās Latvijas aptiekās un kosmētikas loma psoriāzes aprūpē

2017

Problēma: Psoriāze mūsdienās ir izplatīta iekaisuma ādas slimība. Ar psoriāzi slimo dažāda dzimuma un vecuma cilvēki. Psoriāze būtiski ietekmē cilvēka dzīves kvalitāti. To var ārstēt ar lokāliem, sistēmiskiem līdzekļiem un papildus tiek lietoti dažādi kosmētiskie līdzekļi. Psoriāze ir nopietna sociāla problēma, kas skar vismaz 100 miljonus cilvēku visā pasaulē. Pētījuma mērķis: Veikt psoriāzi ārstējošo zāļu un kosmētisko līdzekļu apgrozījuma izpēti vairākās Latvijas aptiekās no 2014. gada janvāra līdz 2016. gada decembrim. Metode: Pētījums tika veikts 3 Latvijas aptiekās, ievācot un apkopojot apgrozījuma datus par lokāli, sistēmiski lietojamām zālēm un kosmētiskajiem līdzekļiem 2014./ 2016.…