Search results for "PSO"
showing 9 items of 679 documents
Psoriasis and Its Impact on In-Hospital Outcome in Patients Hospitalized with Acute Kidney Injury
2020
Background: Psoriasis is a chronic inflammatory disease which affects the body far beyond the skin. Whereas there is solid evidence that chronic skin inflammation in psoriasis drives cardiovascular disease, the impact on renal impairment and acute kidney injury (AKI) is still unclear. We aimed to analyze the impact of psoriasis on the in-hospital outcome of patients hospitalized with AKI. Methods: In this retrospective database study, we investigated data on characteristics, comorbidities, and in-hospital outcomes for all hospitalized patients with AKI stratified for concomitant psoriasis, which were collected by the Federal Office of Statistics in Germany between 2005 and 2016. Results: Am…
Types, triggers and treatment strategies of psoriasis
2013
Psoriasis is a common chronic, immune mediated, inflammatory disease,characterized by periods of exacerbation and remission. Patients with psoriasis have asignificantly impaired quality of life; the disease is associated with substantial burden interms of disability or psychosocial stigmatization. Moreover, in a percentage of patientsthat varies between 5% and 42%, depending on the population studied, psoriatic arthritismay occur.Psoriasis is found worldwide but the prevalence varies among different ethnicgroups. It has a strong genetic component but environmental factors such as ß-haemolyticstreptococcal infection, HIV, stress, and drugs, including ß blockers, antimalarials andlithium can …
Variance Estimation for the Horvitz-Thompson Total Estimator in Unequal Probability Sampling Designs
El 31 congreso federal del PSOE. Madrid, 22-24 enero 1988
2014
El 31 congreso federal del PSOE. Madrid, 22-24 enero 1988. Previo al Vº Congreso del PSPV-PSOE, se celebraba en Madrid el 31 Congreso Federal del PSOE, del 22 al 24 enero 1988. El peso orgánico del PSPV·PSOE en el congreso federal del PSOE se concretaba en ser la segunda federación en afiliación, tras Andalucía, con 29.804 militantes, y 119 delegados, un 13,8% de los 860 delegados electos. PSPV·PSOE: Estos son sus poderes: 29.804 militantes. 119 delegados al congreso federal del partido, que equivalían, casi, al 15% del total de delegados. 453 organizaciones locales, repartidas entre las tres provincias, y 36 ejecutivas comarcales. Militantes suyos presiden la Generalidad, las Cortes Valenc…
Binding and internalization of human papillomavirus type 33 virus-like particles by eukaryotic cells
1995
Infection of cells by human papillomaviruses (HPVs) associated with malignant genital lesions has not been studied because of the lack of an in vitro system and the unavailability of virions. We have now used virus-like particles (VLPs) of HPV type 33 to analyze the initial events in the interaction of the HPV capsid with cell lines. Binding of VLPs to HeLa cells was observed in biochemical assays and by immunofluorescence. VLP binding was inhibited by antisera raised against VLPs but not by monoclonal antibodies recognizing either L1 or L2 epitopes accessible on VLPs. Under saturating conditions, approximately 2 x 10(4) VLPs were bound per cell, with a dissociation constant of about 100 pM…
DNA-induced structural changes in the papillomavirus capsid.
2001
ABSTRACT Human papillomavirus capsid assembly requires intercapsomeric disulfide bonds between molecules of the major capsid protein L1. Virions isolated from naturally occurring lesions have a higher degree of cross-linking than virus-like particles (VLPs), which have been generated in eukaryotic expression systems. Here we show that DNA encapsidation into VLPs leads to increased cross-linking between L1 molecules comparable to that seen in virions. A higher trypsin resistance, indicating a tighter association of capsomeres through DNA interaction, accompanies this structural change.
Papillomavirus assembly requires trimerization of the major capsid protein by disulfides between two highly conserved cysteines.
1998
ABSTRACT We have used viruslike particles (VLPs) of human papillomaviruses to study the structure and assembly of the viral capsid. We demonstrate that mutation of either of two highly conserved cysteines of the major capsid protein L1 to serine completely prevents the assembly of VLPs but not of capsomers, whereas mutation of all other cysteines leaves VLP assembly unaffected. These two cysteines form intercapsomeric disulfides yielding an L1 trimer. Trimerization comprises about half of the L1 molecules in VLPs but all L1 molecules in complete virions. We suggest that trimerization of L1 is indispensable for the stabilization of intercapsomeric contacts in papillomavirus capsids.
The wage curve and local monopsony power
2019
AbstractUsing longitudinal micro-data from Finland, a country with a geographically dispersed population and relatively long distances between local labor markets, this paper examines the responsiveness of the pay level to local unemployment conditions. In particular, this study tests the hypothesis that the pay level is more responsive to the unemployment level in less agglomerated and more remote regions as might be expected if employers have a higher degree of monopsony power in such regions. The results consistently suggest that the pay level is lower in localities with a higher unemployment level and, hence, provide strong support for the so-called wage curve hypothesis, which predicts…