Search results for "PTH"

showing 10 items of 458 documents

Short telomere length is associated with impaired cognitive performance in European ancestry cohorts

2017

AbstractThe association between telomere length (TL) dynamics on cognitive performance over the life-course is not well understood. This study meta-analyses observational and causal associations between TL and six cognitive traits, with stratifications on APOE genotype, in a Mendelian Randomization (MR) framework. Twelve European cohorts (N=17 052; mean age=59.2±8.8 years) provided results for associations between qPCR-measured TL (T/S-ratio scale) and general cognitive function, mini-mental state exam (MMSE), processing speed by digit symbol substitution test (DSST), visuospatial functioning, memory and executive functioning (STROOP). In addition, a genetic risk score (GRS) for TL includin…

0301 basic medicineOncologycognitionNetherlands Twin Register (NTR)Psychometricsgenetic associationgenotypepolymerase chain reactionStatistics as TopicNeuropsychological Testsgenetic riskDISEASE3124 Neurology and psychiatryCohort Studies0302 clinical medicinesingle nucleotide polymorphismcognitive defectYOUNG-ADULTSgenetic variabilitytelomere lengthMedicineGWAScognitive performanceta515depth perceptionNetherlandsRISKlearningmedicine.diagnostic_testdigit symbol substitution testquantitative analysisDEMENTIAGenetic Carrier ScreeningadultarticleMini Mental State ExaminationCognitionta3142episodic memoryznf208 geneMiddle AgedTelomereapolipoprotein E4cohort analysisrtel1 genePsychiatry and Mental healthPROCESSING SPEEDacyp2 genefemaleancestry groupMENDELIAN RANDOMIZATIONOriginal ArticleClinical psychologymedicine.medical_specialtytert genePsychometricsMendelian randomization analysisgenetic risk scoreWhite People03 medical and health sciencesCellular and Molecular NeurosciencemaleInternal medicineMendelian randomizationpleiotropyJournal Article/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_HumansCognitive DysfunctionEffects of sleep deprivation on cognitive performancehumangeneBiological PsychiatryMETAANALYSISAgedterc geneStroop testMini–Mental State Examinationgenome-wide association studyIDENTIFICATIONPsykologi (exklusive tillämpad psykologi)business.industryMORTALITYobfc1 genemajor clinical studyConfidence intervalPsychology (excluding Applied Psychology)030104 developmental biologyexecutive functionDigit symbol substitution testnaf1 geneobservational studybusiness030217 neurology & neurosurgeryStroop effect
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Three-dimensional multiple-particle tracking with nanometric precision over tunable axial ranges

2017

The precise localization of nanometric objects in three dimensions is essential to identify functional diffusion mechanisms in complex systems at the cellular or molecular level. However, most optical methods can achieve high temporal resolution and high localization precision only in two dimensions or over a limited axial (z) range. Here we develop a novel wide-field detection system based on an electrically tunable lens that can track multiple individual nanoscale emitters in three dimensions over a tunable axial range with nanometric localization precision. The optical principle of the technique is based on the simultaneous acquisition of two images with an extended depth of field while …

0301 basic medicineOptical devicesMaterials scienceComplex system02 engineering and technologyTracking (particle physics)Deformable mirrorlaw.invention03 medical and health sciencesOpticsPosition (vector)lawAtomic and Molecular PhysicsElectronicImaging systemsDepth of fieldOptical and Magnetic MaterialsFluorescence microscopy; Imaging systems; Microscopy; Optical devices; Three-dimensional image processing; Electronic; Optical and Magnetic Materials; Atomic and Molecular Physics; and OpticsFluorescence microscopyMicroscopybusiness.industryThree-dimensional image processingFluorescence microscopy; Imaging systems; Microscopy; Optical devices; Three-dimensional image processing; Electronic Optical and Magnetic Materials; Atomic and Molecular Physics and Optics021001 nanoscience & nanotechnologyAtomic and Molecular Physics and OpticsElectronic Optical and Magnetic MaterialsNumerical apertureLens (optics)030104 developmental biologyTemporal resolutionand Optics0210 nano-technologybusinessFluorescence microscopy Imaging systems Microscopy Optical devices Three-dimensional image processing Electronic Optical and Magnetic Materials Atomic and Molecular Physics and Optics
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Mid-region parathyroid hormone-related protein is a genome-wide chromatin-binding factor that promotes growth and differentiation of HB2 epithelial c…

2018

Human parathyroid hormone-related protein (PTHrP) is a polyhormone that undergoes proteolytic cleavage producing smaller peptides which exert diversified biological effects. PTHrP signalization is prominently involved in breast development and physiology, but the studies have been focused onto either N-terminal species or full-length protein introduced by gene transfer techniques. Our present work investigates for the first time the effect of the mid-region PTHrP secretory form, that is, the fragment [38-94], on HB2 non-tumoral breast epithelial cells. We examined viability/proliferation of cells grown in PTHrP-containing media supplemented with different serum concentration and on differen…

0301 basic medicinePTHrPCellClinical BiochemistryBiochemistryCell Line03 medical and health sciences0302 clinical medicineCell Line TumorGene expressionmedicineHumanscell growthBinding siteSettore BIO/06 - Anatomia Comparata E CitologiaCell ProliferationParathyroid hormone-related proteinChemistryCell growthChromatin bindingParathyroid Hormone-Related ProteinCell DifferentiationEpithelial CellsGeneral MedicineChromatinCell biologychromosome decorationSettore BIO/18 - Genetica030104 developmental biologymedicine.anatomical_structure030220 oncology & carcinogenesisbreast cellgene expressionMolecular MedicineFemaleReprogramminghormones hormone substitutes and hormone antagonists
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The role of extracellular calcium in bone metastasis

2016

AbstractThis review summarizes the role of extracellular calcium, as found present in the bone tissue, in the process of bone metastasis.

0301 basic medicinelcsh:Diseases of the musculoskeletal systemIGF insulin-like growth factorPGE-2 prostaglandin E-2Bone tissueFibroblast growth factorM-CSF macrophage colony-stimulating factorPDGF platelet-derived growth factorBone remodelingSK3 small conductance calcium-activated potassium channel 30302 clinical medicineERK extracellular signal-regulated kinaseTGFβ transforming growth factor betaBMP's bone morphogenetic proteinsbiologyAKT AKT8 virus oncogene cellular homologBone metastasislcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogenshumanitiescAMP cyclic adenosine monophosphatemedicine.anatomical_structureOncologyRANKL030220 oncology & carcinogenesisIon channelsCaSR calcium-sensing receptorPTHrP parathyroid hormone-related proteinPlatelet-derived growth factor receptorResearch PaperTRP transient receptor potentialmedicine.medical_specialtychemistry.chemical_elementCalciumRANKL receptor activator of NF-κB ligandlcsh:RC254-28203 medical and health sciencesPLC phospholipase CInternal medicinemedicineExtracellularCaSRET-1 endothelin-1PTEN phosphatase and tensin homolog deleted on chromosome 10business.industryBone metastasismedicine.diseaseFGF fibroblast growth factor030104 developmental biologyEndocrinologyPSA prostate specific antigenchemistryCOPD chronic obstructive pulmonary diseasebiology.proteinCancer researchJNK jun N-terminal kinasePKA protein kinase ARANK receptor activator of NF-κBCalciumlcsh:RC925-935businessMAPK mitogen-activated protein kinaseJournal of Bone Oncology
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Could the Calcium Silicate-Based Sealer Presentation Form Influence Dentinal Sealing? An In Vitro Confocal Laser Study on Tubular Penetration

2021

Dentinal tubule penetration influences root canal treatment sealing. The aim of this study was to compare dentinal penetration of two clinical presentations of silicate-based sealers using confocal laser. Sixty single-rooted human teeth from 50–70 year-old patients extracted for orthodontic/periodontal reasons were used. Canals were prepared using Mtwo system up to 35/0.04, with 5.25% NaOCl irrigation and final irrigation using 17% EDTA. Teeth were randomly assigned into study groups (ni = 20): EndoSequence BC sealer (ES, group 1), BioRoot RCS (BR, group 2); and a control group (nc = 20) with AH Plus (AHP). Root canals were obturated with 35/0.04 gutta-percha (single-cone technique). The sa…

0303 health sciencesmedicine.medical_specialtyChemistrybusiness.industryConfocalRoot canalDentistry030206 dentistryPenetration (firestop)Endodontics03 medical and health scienceschemistry.chemical_compound0302 clinical medicineDentinal Tubulemedicine.anatomical_structureCalcium silicatemedicineGeneral Materials ScienceStatistical analysisPenetration depthbusiness030304 developmental biologyMaterials
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Groupthink and Project Performance: The Influence of Personal Traits and Interpersonal Ties

2015

Contains fulltext : 166103.pdf (Publisher’s version ) (Closed access) This study explores whether the negative impact of “groupthink concurrence-seeking behavior” (GTB) on business process reengineering (BPR) projects is affected by group members personal traits and interpersonal ties within the group. To this purpose we conduct and present the results of a longitudinal controlled field experiment over 18 BPR projects lasting 3 months and involving 18 teams comprising 71 first-year MBA students. The main contribution of this study is twofold. First, we explicitly consider and measure the core construct of groupthink phenomenon: that is, GTB. Existing organizational behavior literature has, …

05 social sciencesApplied psychologyConscientiousnessBehavioral operations managementInterpersonal communicationBusiness process reengineeringManagement Science and Operations ResearchSettore ING-IND/35 - Ingegneria Economico-GestionaleIndustrial and Manufacturing EngineeringBusiness process reengineeringInterpersonal tiesOrganizational behaviorPhenomenonConcurrence-seeking behaviorManagement of Technology and InnovationBehavioral operations management; Business process reengineering; Concurrence-seeking behavior; Groupthink; Industrial and Manufacturing Engineering; Management Science and Operations Research; Management of Technology and Innovation0502 economics and business050211 marketingPerceived controlMarketingPsychologyConstruct (philosophy)Institute for Management ResearchGroupthink050203 business & management
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Expert In-depth Interview on Development and Efficiency of “RIGA International Airport” Reflecting Factors

2016

Abstract The aim of the paper is to identify development ways and effectiveness of RIGA International Airport. Theoretical evidence was examined and expert in-depth interview was carried out to explore the main circumstances affecting RIGA International Airport functioning. Findings of the study show that there are positive tendencies in the field of airport efficiency and development, but improvement is needed primarily for coordinating visions and resources managed by both state and airport administration bodies.

050210 logistics & transportationEngineeringVisionHF5001-6182business.industry05 social sciencesfactor analysisriga international airport.Public relationsInternational airportRIGA International AirportEconomics as a scienceIn depth interviewsairport developmentComputerApplications_MISCELLANEOUS0502 economics and businessOperations managementBusinessexpert in-depth interviewbusinessBusiness managementHB71-74050203 business & managementAirport developmentEconomics and Business
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Comparison between SMOS Vegetation Optical Depth products and MODIS vegetation indices over crop zones of the USA

2014

The Soil Moisture and Ocean Salinity (SMOS) mission provides multi-angular, dual-polarised brightness temperatures at 1.4 GHz, from which global soil moisture and vegetation optical depth (tau) products are retrieved. This paper presents a study of SMOS' tau product in 2010 and 2011 for crop zones of the USA. Retrieved tau values for 504 crop nodes were compared to optical/IR vegetation indices from the MODES (Moderate Resolution Imaging Spectroradiometer) satellite sensor, including the Normalised Difference Vegetation Index (NDVI), Enhanced Vegetation Index (EVE), Leaf Area Index (LAI), and a Normalised Difference Water Index (NOW!) product. tau values were observed to increase during the…

2. Zero hunger010504 meteorology & atmospheric sciences0211 other engineering and technologiesSoil ScienceGrowing seasonGeology02 engineering and technologyVegetationEnhanced vegetation index01 natural sciencesNormalized Difference Vegetation Indexvegetation optical depthLinear regressionEnvironmental scienceL-band radiometryModerate-resolution imaging spectroradiometerComputers in Earth SciencesLeaf area indexoptical vegetation indices[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processingWater contentSMOS021101 geological & geomatics engineering0105 earth and related environmental sciencesRemote sensingRemote Sensing of Environment
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Effect of cactus pear cultivation after Mediterranean maquis on soil carbon stock, δ13C spatial distribution and root turnover

2014

Abstract Mediterranean ecosystems are characterized by nearly complete replacement of natural vegetation by intensive croplands and orchards leading to strong soil degradation. Organic carbon is usually accumulated in soils under maquis leading to partial regeneration of fertility for future agricultural use. The aim of this work was to investigate the effect of land use change from maquis to agriculture on soil organic carbon (SOC) stock and its spatial distribution in a Mediterranean system. Three Mediterranean land use systems (seminatural vegetation, cactus pear crop and olive grove) were selected in Sicily and analysed for soil C stocks and their δ13C. Total SOC and δ13C were measured …

2. Zero hungerMediterranean climatePEARSettore AGR/05 - Assestamento Forestale E SelvicolturaSoil organic matterδ13C natural abundance Soil organic matter Spatial and depth distribution Root turnover Land use change Carbon sequestrationSoil carbon15. Life on landSettore AGR/02 - Agronomia E Coltivazioni ErbaceeAgronomySoil retrogression and degradationSoil waterCactusSoil horizonEnvironmental scienceEarth-Surface ProcessesCATENA
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Design and implementation of PET detectors based on monolithic crystals and SiPMs

2018

Esta tesis doctoral se centra tanto en el diseño como en la validación experimental de detectores de rayos gamma para escáneres de tomografía por emisión de positrones (PET, del inglés Positron Emission Tomography). El objetivo principal de esta tesis es el diseño de innovadores bloques detectores PET de alto rendimiento. La técnica PET constituye una de las principales herramientas diagnósticas en medicina nuclear, que es una especialidad médica que utiliza sustancias radiactivas con fines diagnósticos y terapéuticos. Esta técnica de imagen médica permite visualizar procesos fisiológicos y bioquímicos del cuerpo humano in vivo, mediante la administración del elemento radiotrazador. Los rad…

240606 Física MédicaMonolithic blockPositron emission tomography (PET)Depth of interaction (DOI)Medical imagingSilicon photomultiplierMagnetic resonance (MRI)
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