Search results for "PTO"
showing 10 items of 28599 documents
Suitability of MMGBSA for the selection of correct ligand binding modes from docking results
2019
The estimation of the correct binding mode and affinity of a ligand into a target protein using computational methods is challenging. However, docking can introduce poses from which the correct binding mode could be identified using other methods. Here, we analyzed the reliability of binding energy estimation using the molecular mechanics‐generalized Born surface area (MMGBSA) method without and with energy minimization to identify the likely ligand binding modes within docking results. MMGBSA workflow (a) outperformed docking in recognizing the correct binding modes of androgen receptor ligands and (b) improved the correlation coefficient of computational and experimental results of rescor…
Enhancing Light Emission in Interface Engineered Spin-OLEDs through Spin-Polarized Injection at High Voltages
2019
The quest for a spin-polarized organic light-emitting diode (spin-OLED) is a common goal in the emerging fields of molecular electronics and spintronics. In this device, two ferromagnetic (FM) electrodes are used to enhance the electroluminescence intensity of the OLED through a magnetic control of the spin polarization of the injected carriers. The major difficulty is that the driving voltage of an OLED device exceeds a few volts, while spin injection in organic materials is only efficient at low voltages. The fabrication of a spin-OLED that uses a conjugated polymer as bipolar spin collector layer and ferromagnetic electrodes is reported here. Through a careful engineering of the organic/…
L'eldorado Bitcoin
2018
Conçu par ses inventeurs comme le fondement d'un nouvel ordre monétaire, le Bitcoin semble avoir été rattrapé par la finance et devenir l'occasion de spéculations juteuses. Presque 10 ans après le lancement du Bitcoin, Bercy souhaiterait, avec l'aide de l'Autorité des Marchés Financiers et d'une réglementation souple et incitative, faire de Paris la place financière la plus attractive pour les ICO (Initial Coin Offering), ces levées de fonds en cryptomonnaies qui ont connu une progression record au premier trimestre de l'année 2018. Début janvier, d'autres pays tels la Chine ou la Corée du Sud durcissaient leurs positions face à ce nouvel écosystème, tandis que des projets de monnaies digit…
Erradicando la xenofobia y la aporofobia desde la compasión ética como capacidad clave de la neuroeducación moral
2021
Drawing on the contributions of some of the most recent and relevant studies on neuroethics and moral neuroeducation, this paper undertakes an analysis of compassion. In order to focus on the results of this neuroscientific research a reductionist naturalist framework is set aside in order to embrace the broader outlook of a moral neuroeducation that, firstly, refuses to reduce its normative character to the human capacity for evolutionary adaptation; and, secondly, seeks to locate within the brain the neuronal foundations for the development of a capacity for compassion towards those of one’s own community, and also those from outside it. Thereby, this capacity for compassion moves beyond …
Modelo predictivo de mortalidad a largo plazo en el trasplante hepático del adulto
2015
El trasplante hepático es el tratamiento de elección de muchas hepatopatías terminales y un procedimiento que ha ido evolucionando desde sus inicios, mejorando sus resultados con el paso del tiempo. A pesar de que nuestro país es uno de los que presentan las tasas de donación más altas del mundo, debido al incremento en el número de indicaciones para la realización de un trasplante hepático, porcentaje de pacientes que fallecen en lista de espera se cifra en torno al 5 %. Por ello se continúa investigando y buscando modelos predictivos y de asignación de injertos a fin de mejorar la eficiencia global del procedimiento. En nuestro trabajo planteamos como objetivo el desarrollo de un modelo p…
Underwater archaeological mosaicing
2006
Archaeological mosaicing is one of the challenges of the computer vision community and it can be faced in a 2D or 3D approach. This contribution regards a methodology to do a mosaic of an underwater bi-dimensional scene. A number of problems arise from the acquisition of images by a remote operated vehicle. Radial distortion, poor luminosity, cloud water, presence of artefacts are part of the issues that can occur; for instance, the radial distortion has been corrected to improve the quality of the input images. Keypoints detection (through SIFT transform), Singular Value Decomposition, Random Samples Consensus are some of the techniques applied in our method. This contribution regards the …
Effects of cannabinoids on spontaneous mechanical activity of mouse ileal longitudinal muscle.
2007
Proprioceptive response strength in the primary sensorimotor cortex is invariant to the range of finger movement
2023
Available online 13 February 2023 Proprioception is the sense of body position and movement that relies on afference from the proprioceptors in muscles and joints. Proprioceptive responses in the primary sensorimotor (SM1) cortex can be elicited by stim- ulating the proprioceptors using evoked (passive) limb movements. In magnetoencephalography (MEG), propri- oceptive processing can be quantified by recording the movement evoked fields (MEFs) and movement-induced beta power modulations or by computing corticokinematic coherence (CKC) between the limb kinematics and cortical activity. We examined whether cortical proprioceptive processing quantified with MEF peak strength, relative beta supp…
No phylogeographic structure in the circumpolar snowy owl (Bubo scandiacus)
2008
The snowy owl (Bubo scandiacus) is a nomadic species with a circumpolar distribution. It has recently declined in the western Palearctic and may thus be worthy of special consideration for conservation. We investigated genetic structure in three well separated geographic regions within the snowy owls’ breeding range. We sequenced two mitochondrial genes; the control region and cytochrome b, and two Z-chromosome introns; VLDLR-9 and BRM-15. We found no phylogeographic structure among the sampled regions, indicating high levels of gene flow in the recent past and possibly still today. Intra-population diversity did not vary between regions for the control region, but for Cyt b, North American…
Galvenie akūta retrovirāla sindroma simptomi, ādas un gļotādas izpausmes HIV pozitīviem pacientiem korelācijā ar imūnsupresiju un CD4 T šūnu skaitu L…
2018
Ievads: HIV ir viens no visplašāk izplatījiem vīrusu patogēniem pasaulē. Slimības akūtās fāzes izpausmes ir grūti pamanāmas. Pašreizējie pētījumi liecina, ka svaigi inficēti pacienti gūst priekšrocības no agrīnas diagnostikas attiecībā uz slimības gaitu un dzīves pagarināšanu. Tā kā ādas izpausmes ir vienas no visbiežāk sastopamajām, ir svarīgi tās kritiski izvērtēt gadījumā, ja tās parādās citādi veselīga izskata pacientam. Mērķi: Pētījuma mērķis ir analizēt akūtā retrovīrusu sindroma (ARS) galvenos simptomus, lai veicinātu diagnostiku jau akūtas HIV infekcijas laikā, un noteikt, vai pastāv cieša saikne starp noteiktu ādas bojājumu rašanos un CD4 T šūnu skaitu. Materiāli un metodes: pētīju…