Search results for "PTO"
showing 10 items of 28599 documents
Increased sensitivity of the alpha-2 neuronal nicotinic receptor causes familial epilepsy with nocturnal wandering and ictal fear
2006
Thermodynamics and kinetics of ion translocation in the human wild-type and E-1_A α7 nicotinic receptor
2021
We use an all-atom model of the human nicotinic acetylcholine receptor α7 in a conductive conformation, to provide the first available mapping of the potential of mean force for the ion translocation across the channel. The modeling is based on MD simulations combined with the milestoning method with Voronoi tessellation. The quality of the protein model and description is confirmed by the agreement with experimental data for proteins of the same family. The specific mutation E-1 ' A at the cytoplasmatic filter is here shown to strongly affect both sodium and chloride permeation, leading to a complete inversion of selectivity.
Conformational Changes in Acetylcholine Binding Protein Investigated by Temperature Accelerated Molecular Dynamicscottone
2014
Day and Night Control of COPD and Role of Pharmacotherapy: A Review
2020
Abstract The topic of 24-hour management of COPD is related to day-to-night symptoms management, specific follow-up and patients’ adherence to therapy. COPD symptoms strongly vary during day and night, being worse in the night and early morning. This variability is not always adequately considered in the trials. Night-time symptoms are predictive of higher mortality and more frequent exacerbations; therefore, they should be a target of therapy. During night-time, in COPD patients the supine position is responsible for a different thoracic physiology; moreover, during some sleep phases the vagal stimulation determines increased bronchial secretions, increased blood flow in the bronchial circ…
Role of the NF-kB pathway and nitric oxide in mammary gland involution after weaning. Implications in breast cancer
2013
INTRODUCCIÓN La glándula mamaria es un órgano dinámico que alcanza su máximo desarrollo funcional con la lactancia, momento en el cual, a través de la producción de leche, aporta nutrientes y protección inmunológica a las crías de los mamíferos. Cuando la lactancia finaliza con el destete, el exceso de tejido glandular debe desaparecer y la glándula sufre una extensa remodelación hasta alcanzar nuevamente un estado pre-gestacional, preparada para un nuevo ciclo. La involución del tejido mamario es un proceso complejo durante el cual se suceden de forma coordinada una serie de eventos como la muerte de las células epiteliales secretoras, la proliferación de tejido adiposo circundante y la re…
Impact of pharmacological and environmental manipulations on neuronal structural plasticity and dynamics
2017
El sistema nervioso de vertebrados es uno de los más estudiados, aunque peor comprendidos, del organismo de mamíferos. Desde que Ramón y Cajal postuló su teoría celular de este sistema (Ramón y Cajal 1909), la neurona se ha postulado como su unidad funcional. Sin embargo, durante las últimas décadas se ha revolucionado la visión que se tenía de éste. Una de las percepciones más asentadas era que, tras el desarrollo embrionario, el sistema nervioso se mantenía inmutable. Sin embargo, ahora sabemos que diferentes formas de plasticidad gobiernan su adaptación, que son necesarias para importantes procesos del día a día, tales como el aprendizaje y la memoria (Smythies 2002; Berlucchi and Buchte…
Latest Developments and Results of Radiation Tolerance CMOS Sensors with Small Collection Electrodes
2020
The development of radiation hard Depleted Monolithic Active Pixel Sensors (DMAPS) targets the replacement of hybrid pixel detectors to meet radiation hardness requirements of at least 1.5e16 1 MeV neq/cm2 for the HL-LHC and beyond. DMAPS were designed and tested in the TJ180 nm TowerJazz CMOS imaging technology with small electrodes pixel designs. This technology reduces costs and provides granularity of 36.4x36.4 um2 with low power operation (1 uW/pixel), low noise of ENC < 20 e-, a small collection electrode (3 um) and fast signal response within 25 ns bunch crossing. This contribution will present the latest developments after the MALTA and Mini-MALTA sensors. It will illustrate the imp…
Nonlinear dissipation phenomena in optomechanics
2016
Yksikään kvanttisysteemi ei voi olla täysin eristetty ympäristöstään, mikä johtaa informaation välittymiseen systeemin ja ympäristön välillä. Optomekaniikassa, missä tyypillinen tutkittava systeemi on peileistä koostuva optinen kaviteetti yhdistettynä mekaaniseen värähtelijään, systeemin ja ympäristön lineaarisesta kytkennästä johtuvat dissipaatioilmiöt ovat hyvin tunnettuja. Epälineaarisia ilmiöitä ei kuitenkaan ymmärretä yhtä laajasti. Tutkin epälineaarista kytkentää kaviteetin ja lämpökylvyn välillä ja havainnollistan tästä kytkennästä johtuvia ilmiöitä kuten epälineaarista dissipaatiota. Esitän myös optisen kaviteetin epälineaarisen dissipaation oikeuttavan mallin, missä optinen kavitee…
A four-session acceptance and commitment therapy based intervention for depressive symptoms delivered by masters degree level psychology students: a …
2013
Background:Depressive symptoms are one of the main reasons for seeking psychological help. Shorter interventions using briefly trained therapists could offer a solution to the ever-rising need for early and easily applicable psychological treatments.Aims:The current study examines the effectiveness of a four-session Acceptance and Commitment Therapy (ACT) based treatment for self-reported depressive symptoms administered by Masters level psychology students.Method:This paper reports the effectiveness of a brief intervention compared to a waiting list control (WLC) group. Participants were randomized into two groups: ACT (n= 28) and waiting list (n= 29). Long-term effects were examined using…
Neironu tīklu metodes kriptovalūtu vērtību prognozēšanai
2018
Kriptovalūtu tirgus nestabilitātes dēļ, pašam prognozēt, kā notiks vērtību svārstības ir gandrīz neiespējami. Tāpēc šajā darbā tiks apskatītas vairākas metodes, ar kuru palīdzību prognozēs dažādu kriptovalūtu vērtību tuvākajā nākotnē, izmantojot mākslīgos neironu tīklus. Darba mērķis ir salīdzināt dažādas metodes, kā analizēt kriptovalūtu datus un noteikt to vērtību tuvākajā nākotnē, balstoties gan uz dažādu kriptovalūtu vēsturisko informāciju, gan uz sociālā tīkla Twitter ierakstiem. Trenējot neironu tīklus, kuram tiek padoti sociālo tīklu dati apvienojumā ar kriptovalūtu informāciju, tika sasniegts pat 10%-15% pieaugums prognozēšanas precizitātei, salīdzinot ar parastu kriptovalūtu vēstur…