Search results for "PULMONARY"

Is the Parsonnet's score a good predictive score of mortality in adult cardiac surgery: assessment by a French multicentre study.

1997

Objecti6e: Parsonnet proposed a preoperative score (‘‘initial Parsonnet’s score’’, which predicts the hospital mortality of adult cardiac surgery. This score was then modified by including several risk factors used in the ‘SUMMIT’ system (‘‘modified Parsonnet’s score’’, 44 variables). We wanted to assess the predictive value of these two scores in a French surgical population. Methods: From December 1992 to April 1993, in France, we organised a prospective multicentre study on adult cardiac surgery mortality and morbidity. Data on 6649 patients were included. We analysed statistically the predictive value of each risk factor and of the two scores on mortality and morbidity at one month. Res…

Evidenz für eine frühzeitige Therapie der COPD mit Tiotropium

2012

Hintergrund: Die Wirksamkeit von Tiotropium versus Kontrolle wurde in einer praspezifizierten Subgruppenanalyse der 4-Jahres-Studie „Understanding Potential Long-term Impacts on Function with Tiotropium“ bei Patienten mit chronisch obstruktiver Lungenerkrankung (COPD) mittleren Schweregrades (GOLD II) untersucht und erstmals den gepoolten Ergebnissen aus den schwereren Krankheitsstadien (GOLD III/IV) gegenubergestellt. Methode: Randomisierte multizentrische, doppelblinde, kontrollierte Studie mit parallelem Gruppenvergleich bei 5993 Patienten uber 4 Jahre. Die Patienten erhielten entweder Tiotropium 18 µg einmal taglich oder Plazebo. Als Endpunkte wurden der jahrliche FEV1-Abfall und weiter…

Professional drivers and private drivers from Bogotá: Diagnosis of sociodemographic conditions and general well-being [exploratory analysis]

2018

espanolA pesar que los accidentes de trafico son reconocidos mundialmente como un problema de salud publica y que en Colombia representan la segunda causa de muerte violenta, hay una falta de investigacion en torno al tema, hecho que senala la importancia de iniciar acciones concretas. En consonancia con lo anterior, el objetivo de la presente investigacion fue estudiar dos tipos de poblacion de conductores, a saber, conductores profesionales y particulares en la ciudad de Bogota, mediante un analisis y comparacion de su situacion sociodemografica y de salud general. Con tales fines, una investigacion de corte transversal fue llevada a cabo, en la que participaron 500 conductores (250 profe…

Do Saharan Dust Days Carry a Risk of Hospitalization From Respiratory Diseases for Citizens of the Canary Islands (Spain)?

2021

Background: Saharan dust meets the Canary Islands at the beginning of its westward path across the North Atlantic, exceeding the European daily levels for PM10; for this reason, their two provincial capital cities, constitute optimal sites where to evaluate the health effects of this natural event. Objectives: To assess the short-term association between Saharan Dust Days (SDDs) and respiratory morbidity in the two capital cities. Methods: We carried out a time-series analysis with daily emergency hospital admissions due to all respiratory system diseases, chronic obstructive pulmonary disease (COPD) and asthma between 2001 and 2005, assessing the independent effect of SDDs, defined accordi…

Standardised methodology of sputum induction and processing. Future directions

2002

Sympathetic activation in patients with heart failure and central sleep apnoea: is it friend or foe?

2023

This sub-study of the SERVE-HF study found unchanged peripheral nervous sympathetic activity (MSNA) in heart failure patients on medical treatment or on ASV after 12 weeks. Reduced MSNA was associated with worse prognosis only in the ASV group

Investigation and management of residual sleepiness in CPAP-treated patients with obstructive sleep apnoea: the European view

2022

International audience; Excessive daytime sleepiness (EDS) is a major symptom of obstructive sleep apnoea (OSA), defined as the inability to stay awake during the day. Its clinical descriptors remain elusive, and the pathogenesis is complex, with disorders such as insufficient sleep and depression commonly associated. Subjective EDS can be evaluated using the Epworth Sleepiness Scale, in which the patient reports the probability of dozing in certain situations; however, its reliability has been challenged. Objective tests such as the multiple sleep latency test or the maintenance of wakefulness test are not commonly used in patients with OSA, since they require nocturnal polysomnography, da…

Sleep under exposure to high-frequency electromagnetic fields.

2004

The controversy about potential health hazards associated with the exposure to electromagnetic fields (EMF) has been recently stimulated by the increasing use of mobile telecommunication devices. Attention has focused here on non-thermal effects of low-level high-frequency radiation, which does not lead to a heating of tissue. Scientific literature on the effects of high-frequency EMFs on sleep is reviewed. The epidemiological studies provide no evidence that sleep disturbances are a relevant complaint under exposure to such fields. Recent sleep laboratory studies have revealed a number of slight effects. Despite their heterogeneity, there seems to be some consistency regarding a slight sle…

Solitäre fibröse Pleuratumoren - Seltene Tumoren mit unvorhersehbarem klinischen Verhalten

2000

Solitary fibrous tumors of the pleura are rare tumors with unpredictable clinical behaviour. We report about two patients with an incidental finding of an intrathoracic tumor. Preoperative diagnosis was uncertain. In both patients, a solid tumor of the pleura was resected en bloc in combination with a wedge resection of the lung following anterolateral thoracotomy. The postoperative course was eventful. Six months after primary complete resection there were no signs of tumor recurrence.

Nintedanib in non-small cell lung cancer: from preclinical to approval

2015

Angiogenesis is a driving force of a tumor’s development. Targeting this process is an attractive option, as this is a feature shared by most of the solid tumors. A lot of antiangiogenic drugs have been developed following this path, including bevacizumab, sorafenib, sunitinib, vandetanib, ramucirumab, motesanib and many others. The latest drug of this class to be approved for patients with non-small cell lung cancer (NSCLC) was nintedanib, a triple angiokinase inhibitor. This molecule targets vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF) and fibroblast growth factor (FGF) pathways, avoiding the tumor’s switch to normal escape mechanisms. The pharmacokine…