Search results for "PYD"
showing 7 items of 7 documents
Association of 5-FU Therapeutic Drug Monitoring to DPD Phenotype Assessment May Reduce 5-FU Under-Exposure
2020
In order to limit 5-fluorouracil (5-FU) toxicity, some health agencies recommend evaluating dihydropyrimidine dehydrogenase (DPD) deficiency before any 5-FU treatment introduction. In our study, we investigated relationships between 5-FU clearance and markers of DPD activity such as uracilemia (U), dihydrouracilemia (UH2)/U ratio, or genotype of the gene encoding DPD (DPYD). All patients with gastrointestinal cancers who received 5-FU-based regimens form March 2018 to June 2020 were included in our study. They routinely benefited of a pre-therapeutic DPYD genotyping and phenotyping. During 5-FU infusion, blood samples were collected to measure 5-FU steady-state concentration in order to ada…
Minori stranieri non accompagnati e comunità ospitanti. Verso un programma integrato di interventi.
Elecciones primarias en España. 1993-2015
2015
“Elecciones primarias en España. 1993-2015 ” analiza la intro¬ducción y desarrollo de las elecciones primarias de los partidos políti¬cos en España, y como una forma de participación típica de la política de los EE.UU., va consiguiendo arraigar en los partidos españoles. Será el PSOE el primero que implante el sistema de primarias (Con¬ferencia Política del PSPV en 1993); después en las elecciones pri¬marias para elegir candidato a la Presidencia del Gobierno de España (Almunia-Borrell), por elección directa entre todos los afiliados socia¬listas (1998); y a través de primarias abiertas a simpatizantes en la elección del candidato socialista a la Presidencia de la Generalitat Valenciana (20…
Primarias en la Comunitat Valenciana. 2014-2015. Partidos valencianos y primarias para la elección de candidato a la Presidencia de la Generalitat en…
2015
A lo largo de 2014 y principios de 2015, casi todos los partidos políticos que se van a presentar a las elecciones de 2015 (locales, autonómicas y generales) van a realizar algún tipo de primarias para la selección de sus candidatos, a excepción del PP. Los partidos que celebran primarias abiertas en la Comunidad Valenciana -CV- son el PSPV - presenciales-, EUPV, Compromís y Podemos, estos tres admiten también voto por Internet y correo. Solo votaban en primarias los afiliados en UPyD (sin avales) y C´s (aval 10% censo). Sin primarias el PP. El candidato lo decide el dedo de Mariano Rajoy.
Optical properties of Ge-oxygen defect center embedded in silica films
2007
The photo-luminescence features of Ge-oxygen defect centers in a 100nm thick Ge-doped silica film on a pure silica substrate were investigated by looking at the emission spectra and time decay detected under synchrotron radiation excitation in the 10-300 K temperature range. This center exhibits two luminescence bands centered at 4.3eV and 3.2eV associated with its de-excitation from singlet (S1) and triplet (T1) states, respectively, that are linked by an intersystem crossing process. The comparison with results obtained from a bulk Ge-doped silica sample evidences that the efficiency of the intersystem crossing rate depends on the properties of the matrix embedding the Ge-oxygen defect ce…
Determination of DPYD polymorphisms before treatment with chemotherapy with a pyrimidine: Should we continue doing it?
2018
Hyaluronic acid dressing of Hydrophobic Carbon Nanodots: a Self-assembling Strategy of Hybrid Nanocomposites with Theranostic Potential
2021
We propose a rational design of hyaluronic acid-dressed red-emissive carbon dots (CDs), with a well-structured hydrophobic core capable of locally delivering high amount doxorubicin (Doxo) (> 9% w/w) and heat (hyperthermia) in a light stimuli sensitive fashion. We combined in a unique micelle-like superstructure the peculiar optical properties of CDs (NIR photothermal conversion and red fluorescence) with the ability of hyaluronic acid (HA) shell of stabilizing nanomedicines in aqueous environment and recognizing cancer cells overexpressing CD44 receptors on their membranes, thus giving rise to smart theranostic agents useful in cancer imaging and NIR-triggered chemo-phototherapy of solid t…