Search results for "Pact"
showing 10 items of 2355 documents
Development and implementation of guidelines for the management of depression: a systematic review
2020
To evaluate the development and implementation of clinical practice guidelines for the management of depression globally.We conducted a systematic review of existing guidelines for the management of depression in adults with major depressive or bipolar disorder. For each identified guideline, we assessed compliance with measures of guideline development quality (such as transparency in guideline development processes and funding, multidisciplinary author group composition, systematic review of comparative efficacy research) and implementation (such as quality indicators). We compared guidelines from low- and middle-income countries with those from high-income countries.We identified 82 nati…
Evaluating hazardous waste generation in for-profit outpatient haemodialysis centres
2015
SUMMARYBackground “Green” haemodialysis management to reduce the environmental impact of haemodialysis is growing. Objectives Dealing with hazardous waste production could heighten healthcare professionals’ awareness of this problem, and improve their healthcare involvement in environmental sustainability and environmental-friendliness. Design and Measurements A list of for-profit outpatient haemodialysis centres in the Valencian Community (E Spain) was compiled. Data on their hazardous waste production from 2008 to 2012 through the annual waste reports issued by official organisations competent in environmental issues were collected. Results There are 22 for-profit dialysis centres, that m…
Spaniards’ Secular Ritual
2015
Football is the most popular sport in Spain, and its strong attraction is clearly reflected in its economic dimensions. Recent estimations of the economic influence of Spanish football concluded that it had an effect on production of some €4,000,000,000, almost one per cent of the general Gross National Product (GNP) and about 1.2 per cent of the GNP of the services sector (LFP, 2004). Adding in other indirect effects, such as employee remuneration and the gross operating surplus, the total impact of Spanish football on the Spanish economy climbs to €8,066,000,000, approximately 1.7 per cent of the overall GNP and 2.5 per cent of the GNP of the services sector, and it provides direct or ind…
A Full-Scale Agent-Based Model to Hypothetically Explore the Impact of Lockdown, Social Distancing, and Vaccination During the COVID-19 Pandemic in L…
2021
Background The COVID-19 outbreak, an event of global concern, has provided scientists the opportunity to use mathematical modeling to run simulations and test theories about the pandemic. Objective The aim of this study was to propose a full-scale individual-based model of the COVID-19 outbreak in Lombardy, Italy, to test various scenarios pertaining to the pandemic and achieve novel performance metrics. Methods The model was designed to simulate all 10 million inhabitants of Lombardy person by person via a simple agent-based approach using a commercial computer. In order to obtain performance data, a collision detection model was developed to enable cluster nodes in small cells that can b…
An investigation of the mechanical properties of rubber modified asphalt mixtures using a modified dry process
2017
Incorporating recycling tyres into asphalt mixtures contributes to solving a serious environmental problem as well as the potential of improving the mechanical performance of asphalt mixtures. The recycled tyre rubber is added by two technologies known as the dry process (when rubber particles are treated as an aggregate modifier) and the wet process (when rubber particles are treated as a binder modifier). Although, the dry process is easier and requires minimal or no modification in the asphalt plant, the inconsistency in field performance makes the dry process not widely used. The main reason for this is believed to be the lack of interaction between the rubber particles and binder. In o…
WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model…
2009
Parkinson's disease (PD) is characterized by the progressive loss of nigrostriatal dopamine neurons leading to motor disturbances and cognitive impairment. Current pharmacotherapies relieve PD symptoms temporarily but fail to prevent or slow down the disease progression. In this study, we investigated the molecular mechanisms by which the non-selective cannabinoid receptor agonist WIN55,212-2 (WIN) protects mouse nigrostriatal neurons from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity and neuroinflammation. Stereological analyses showed that chronic treatment with WIN (4 mg/kg, intraperitoneal), initiated 24 h after MPTP administration, protected against MPTP-ind…
Mechanical impact of the antagonist muscles during maximal dorsiflexion is action mode dependent
2019
Maximal voluntary contraction (MVC) has long been considered as the best measure of neuromuscular performance. However, when MVC is paired with electromyographic (EMG) activity recording it has bee...
Enantioselective transformation of fluoxetine in water and its ecotoxicological relevance
2017
European legislation focusing on water quality is expected to broaden to encompass several pharmaceuticals as priority hazardous substances. This manuscript aims to challenge current regulatory approaches that do not recognize stereochemistry of chiral pharmaceuticals by testing the hypothesis that environmental transformation and effects of chiral pharmaceuticals are stereoselective. Our experiments revealed that, while degradation of chiral fluoxetine (FL) in river water occurs via non-enantioselective photochemical and mildly-enantioselective microbial processes favoring the (R)-enantiomer, a pronounced enantioselectivity favoring (S)-FL (leading to the formation of (S)-NFL (norfluoxetin…
The pesticides use and the risk for head and neck cancer: A review of case-control studies
2020
Background Tobacco, alcohol consumption, and HPV infection are the most common risk factors for head and neck cancer (HNC). Despite of this, recent evidences are growing on the association between long-term exposure to pesticides and the risk of chronic diseases, including different types of cancer. The present review evaluated in current literature evidence of an association between exposure to pesticides and the occurrence of HNCs. Material and Methods A literature search of the case-control studies was conducted in the PubMed, Web of science and Cochrane databases. Methodological quality of each study was rated with the Scottish Intercollegiate Guidelines Network (SIGN 50) checklist. Res…
Cardinal estimates involving the weak Lindelöf game
2021
AbstractWe show that if X is a first-countable Urysohn space where player II has a winning strategy in the game $$G^{\omega _1}_1({\mathcal {O}}, {\mathcal {O}}_D)$$ G 1 ω 1 ( O , O D ) (the weak Lindelöf game of length $$\omega _1$$ ω 1 ) then X has cardinality at most continuum. This may be considered a partial answer to an old question of Bell, Ginsburg and Woods. It is also the best result of this kind since there are Hausdorff first-countable spaces of arbitrarily large cardinality where player II has a winning strategy even in the weak Lindelöf game of countable length. We also tackle the problem of finding a bound on the cardinality of a first-countable space where player II has a wi…