Search results for "Pain syndrome"

Complex regional pain syndrome - phenotypic characteristics and potential biomarkers

2018

Complex regional pain syndrome (CRPS) is a pain condition that usually affects a single limb, often following an injury. The underlying pathophysiology seems to be complex and probably varies between patients. Clinical diagnosis is based on internationally agreed-upon criteria, which consider the reported symptoms, presence of signs and exclusion of alternative causes. Research into CRPS biomarkers to support patient stratification and improve diagnostic certainty is an important scientific focus, and recent progress in this area provides an opportunity for an up-to-date topical review of measurable disease-predictive, diagnostic and prognostic parameters. Clinical and biochemical attribute…

Knee arthroscopy and exercise versus exercise only for chronic patellofemoral pain syndrome: a randomized controlled trial

2007

BACKGROUND: Arthroscopy is often used to treat patients with chronic patellofemoral pain syndrome (PFPS). As there is a lack of evidence, we conducted a randomized controlled trial to study the efficacy of arthroscopy in patients with chronic PFPS. METHODS: A total of 56 patients with chronic PFPS were randomized into two treatment groups: an arthroscopy group (N = 28), treated with knee arthroscopy and an 8-week home exercise program, and a control group (N = 28), treated with the 8-week home exercise program only. The arthroscopy included finding-specific surgical procedures according to current recommendations. The primary outcome was the Kujala score on patellofemoral pain and function …

Factors related to excessive patellofemoral loading in rearfoot running

2015

Running is recognized as one of the most popular exercise methods. Furthermore, running related injuries have been under the scope for the last few decades. Synchronous function between the segments of the lower limbs is necessary for efficient locomotion. Patellofemoral pain syndrome is a common exercise related syndrome and multifactorial in nature. The purpose of this study was to measure contact forces and frontal plane moments to detect the factors that are associated with atypically high patellofemoral joint loading in rearfoot striking (RFS) running pattern, and moreover, which could possibly contribute to development of the patellofemoral pain syndrome. 39 team sport female athletes…

Mini-Review: Two Brothers in Crime – The Interplay of TRESK and TREK in Human Diseases

2021

Abstract TWIK-related spinal cord potassium (TRESK) and TWIK-related potassium (TREK) channels are both subfamilies of the two-pore domain potassium (K2P) channel group. Despite major structural, pharmacological, as well as biophysical differences, emerging data suggest that channels of these two subfamilies are functionally more closely related than previously assumed. Recent studies, for instance, indicate an assembling of TRESK and TREK subunits, leading to the formation of heterodimeric channels with different functional properties compared to homodimeric ones. Formation of tandems consisting of TRESK and TREK subunits might thus multiply the functional diversity of both TRESK and TREK …

Standards for the diagnosis and management of complex regional pain syndrome: Results of a European Pain Federation task force.

2019

Background: Complex regional pain syndrome is a painful and disabling post-traumatic primary pain disorder. Acute and chronic complex regional pain syndrome (CRPS) are major clinical challenges. In Europe, progress is hampered by significant heterogeneity in clinical practice. We sought to establish standards for the diagnosis and management of CRPS. Methods: The European Pain Federation established a pan-European task force of experts in CRPS who followed a four-stage consensus challenge process to produce mandatory quality standards worded as grammatically imperative (must-do) statements. Results: We developed 17 standards in 8 areas of care. There are 2 standards in diagnosis, 1 in multi…

Aknu steatozes saistība ar hroniska pankreatīta gaitu

2019

Ievads. Hronisks pankreatīts ir hroniska iekaisīga aizkuņģa dziedzera slimība, kas var novest līdz eksokrīnai un endokrīnai mazspējai. Literatūrā ir atrodami maz dati par aknu steatozes prevalenci hroniska pankreatīta pacientu vidū, lai gan abām šīm slimībām ir kopīgi etioloģiskie faktori. Darba mērķis. Analizēt aknu steatozes prevalenci HP slimniekiem un novērtēt aknu steatozes asociāciju ar HP smaguma pakāpi un komplikācijām. Metodes un materiāli. Pētījums bija retrospektīvs šķērsgriezuma pētījums. Tajā tika iekļauti pacienti no PSKUS Gastroenteroloģijas, hepatoloģijas un uztura terapijas centra, laika periodā no 2016. gada līdz 2019. gadam. Tika apkopoti tādi klīniskie parametri kā demog…

Perioperative management of patients with suspected or severe infection with SARS-CoV-2 coronavirus programmed for the implementation of electronic d…

2020

At the end of 2019, a series of patients affected by lung infection of initially unknown aetiology with clinical presentations very similar to viral pneumonia were registered in China. Sequencing analysis of samples from the lower respiratory tract identified a new type of virus from the family Coronaviridae called SARS-CoV-2 as the causative agent of the outbreak; the agent responsible for the disease that was renamed COVID-19.1 Since then, millions of cases have been identified around the world. The World Health Organization (WHO) initially declared the infection to be a Public Health Emergency of International Concern, and later classed it as a pandemic.2, 3 The vast majority of coronavi…

Current advances and novel research on minimal invasive techniques for musculoskeletal disorders.

2021

Abstract The present review summarized the current advances and novel research on minimal invasive techniques for musculoskeletal disorders. Different invasive approaches were proposed in the physical therapy field for the management of musculoskeletal disorders, such as ultrasound-guided percutaneous needle electrolysis, dry needling, acupuncture and other invasive therapy techniques, discussing about their worldwide status, safety and interventional ultrasound imaging. Indeed, dry needling may be one of the most useful and studies invasive physical therapy applications in musculoskeletal disorders of different body regions, such as back, upper limb, shoulder, arm, hand, pelvis, lower limb…

Lumbar and thoracic sympathetic radiofrequency lesioning in complex regional pain syndrome.

2006

Reduced serum protease activity in Complex Regional Pain Syndrome: The impact of angiotensin-converting enzyme and carboxypeptidases.

2021

Complex Regional Pain Syndrome (CRPS) occurs in about 2% of patients after fracture of the limbs. In an earlier clinical study with 102 probands we have shown that the serum protease network in CRPS might be less effective. Based on these results we hypothesized that angiotensin-converting enzyme (ACE) and carboxypeptidase N (CPN) activity contribute to the differences of labeled bradykinin (DBK) degradation by patients' sera. Details of the enzymatic processes remained however unclear. The contributions of ACE and CPN in the serum degradation of DBK were studied using specific inhibitors. CPN1-ELISA was performed in serum. It was confirmed that the majority of DBK was degraded by ACE and C…