Search results for "Pane"
showing 10 items of 1074 documents
Simvastatin Increases the Ability of Roflumilast N-oxide to Inhibit Cigarette Smoke-Induced Epithelial to Mesenchymal Transition in Well-differentiat…
2014
Cigarette smoking contributes to epithelial-mesenchymal transition (EMT) in COPD small bronchi as part of the lung remodeling process. We recently observed that roflumilast N-oxide (RNO), the active metabolite of the PDE4 inhibitor roflumilast, prevents cigarette smoke-induced EMT in differentiated human bronchial epithelial cells. Further, statins were shown to protect renal and alveolar epithelial cells from EMT. To analyze how RNO and simvastatin (SIM) interact on CSE-induced EMT in well-differentiated human bronchial epithelial cells (WD-HBEC) from small bronchi in vitro. Methods: WD-HBEC were stimulated with CSE (2.5%). The mesenchymal markers vimentin, collagen type I and α-SMA, the e…
Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways.
2010
Mucus hypersecretion and mucin MUC5AC overexpression are pathological features of chronic obstructive pulmonary disease (COPD). This study examines the inhibitory effect of aclidinium, a new long-acting muscarinic antagonist, on MUC5AC expression in human airway epithelial cells. MUC5AC mRNA (RT-PCR) and protein expression (ELISA and immunohistochemistry) were studied in human bronchial tissue and differentiated human airway epithelial cells activated with carbachol (100 μM) or cigarette smoke extract in the absence or presence of aclidinium. Carbachol increased MUC5AC mRNA and protein expression in human bronchus and cultured epithelial cells. Aclidinium inhibited the carbachol-induced MUC…
Aclidinium inhibits cigarette smoke-induced lung fibroblast-to-myofibroblast transition.
2012
Cigarette smoking contributes to lung remodelling in chronic obstructive pulmonary disease (COPD). As part of this remodelling, peribronchiolar fibrosis is observed in the small airways of COPD patients and contributes to airway obstruction. Fibroblast-to-myofibroblast transition is a key step in peribronchiolar fibrosis formation. This in vitro study examined the effect of cigarette smoke on bronchial fibroblast-to-myofibroblast transition, and whether aclidinium bromide inhibits this process. Human bronchial fibroblasts were incubated with aclidinium bromide (10 −9 –10 −7 M) and exposed to cigarette smoke extract. Collagen type I and α-smooth muscle actin (α-SMA) expression were measured …
Aclidinium inhibits human lung fibroblast to myofibroblast transition
2011
Background Fibroblast to myofibroblast transition is believed to contribute to airway remodelling in lung diseases such as asthma and chronic obstructive pulmonary disease. This study examines the role of aclidinium, a new long-acting muscarinic antagonist, on human fibroblast to myofibroblast transition. Methods Human bronchial fibroblasts were stimulated with carbachol (10 −8 to 10 −5 M) or transforming growth factor-β1 (TGF-β1; 2 ng/ml) in the presence or absence of aclidinium (10 −9 to 10 −7 M) or different drug modulators for 48 h. Characterisation of myofibroblasts was performed by analysis of collagen type I and α-smooth muscle actin (α-SMA) mRNA and protein expression as well as α…
Study and simulation of photovoltaic installation connected to the grid with storage system
2016
In the present paper, a new approach to the management of energy resources in a research laboratory is proposed and evaluated by a simulation for the PV installation realized for the Tunisian-Italian cooperation project DE.DU.ENER.T, using renewable energy and economic criteria. The aim of this project is to improve energy efficiency order to minimize the electricity cost consumed at the laboratory, because according to the bills of electricity received we noticed that there is a high consumption of electrical current, from the STEG grid, and especially by the energy intensive equipment such as drying ovens and all the workstations. So we targeted to install a photovoltaic field of 12KWc to…
SAFETY COVER HYDRO-PV Dispositivo domotico multifuzione per la manutenzione e la sicurezza dei pannelli fotovoltaici con aumento dell’efficienza e de…
2018
Con l’aumento dell’uso dell’energia solare, sia in ambito civile che in ambito industriale, diventa sempre più importante il problema della manutenzione e della gestione dei pannelli fotovoltaici.Il dispositivo Safety Cover Hydro - PV, ideato e brevettato dai membri dalla Safety Environmental Engineering (spin-off dell’Università degli Studi di Palermo che opera nell’ambito della Sicurezza Ambientale) consente di superare tali limiti
ChemInform Abstract: Palladium-Catalyzed Skeletal Rearrangement of Spirotricyclic Olefins: A Facile One-Pot Strategy for the Synthesis of a Novel Mot…
2013
The first utilization of acyclic cyclopropane bearing spirocyclic olefines for the generation of stereospecific complex fused ring systems with an achiral catalyst is reported.
Datu vizualizācijas vieta datu noliktavas arhitektūrā: informācijas paneļu lietojums
2020
Maģistra darbs apskata datu vizualizācijas un to pielietojumu studentu datu analīzē, izmantojot informācijas paneļu rīkus. Tika veikts kritēju apskats, izmantojot Gartner uzņēmuma piedāvātos kritērijus un papildināts ar zinātnisko rakstu kritērijiem. Apskatīta datu vizualizācijas nozīme datu noliktavas arhitektūrā. Darba gaitā tika izpētīts informācijas paneļu funkcionalitāte, kādas iespējas sniedz paneļu izmantošana, kā arī problēmas ar ko saskaras informācijas paneļi. Piemērots datu analīzes rīks, ļauj labāk izprast datu būtību un ļauj ātrāk izdarīt secinājumus. Darba mērķis ir izpētīt informācijas paneļu iespējas un pielietot QlikView datu vizualizācijas rīku, kas nodrošina informācijas …
THE PREMIUM PRICE FOR ITALIAN RED WINE QUALITY ATTRIBUTES IN THE JAPANESE MARKET
2015
In this paper we apply the hedonic price model in order to estimate implicit price for the main objective characteristics appearing on the label of Italian wines sold in Japan, easier to identify than sensory attributes by consumers. In this paper, the wine searcher dataset has been used in order to select the retailer price and the research score for 829 wines, for each of which we have observed information about their geographical origin, vintage, grape varieties, vintage, and the alcohol degree. Our results indicate that international grape varieties, alcohol content and the year of production explain the major part of price difference. On the other hand, the origin appellations linked t…
The re Structure of Cyclopropane
2000
A long-standing controversy regarding the re structure of cyclopropane is resolved by performing high-level quantum chemical calculations and analyzing the experimental rotational constants for C3H6 and C3H4D2 augmented by calculated vibrational corrections. For the latter, a least-squares fit yields the following set of parameters: re (CC) = 1.5030(10) A, re(CH) = 1.0786(10) A, and αe(HCH) = 114.97(10)°, which compare favorably with both the pure computational result obtained at the CCSD(T)/cc-pVQZ level as well as an earlier estimate of the re structure of cyclopropane based on analysis of gas-phase electron diffraction data. Our results are in rather poor agreement with a structure base…