Search results for "Papers"
showing 10 items of 345 documents
Patient engagement with research:European population register study
2014
Background Lay involvement in implementation of research evidence into practice may include using research findings to guide individual care, as well as involvement in research processes and policy development. Little is known about the conditions required for such involvement. Aim To assess stroke survivors’ research awareness, use of research evidence in their own care and readiness to be involved in research processes. Methods Cross sectional survey of stroke survivors participating in population-based stroke registers in six European centres. Results The response rate was 74% (481/647). Reasons for participation in register research included responding to clinician request (56%) and to …
Papers on the Conservation of Ancient Monuments and Remains. John Ruskin, Gilbert Scott e la Carta inglese della Conservazione (Londra, 1865)
2019
Il contributo tratta l'evoluzione storico-teorica del Restauro nel Regno Unito durante il XIX secolo, rilevando i fondamentali contributi che condurranno per la prima volta alla diffusione di una carta del Restauro, ovvero i "Papers on the Conservation of Ancient Monuments and Remains", pubblicata a Londra nel 1865. La ricerca si avvia chiarendo il significato che Edward August Freeman aveva paradossalmente assegnato al termine "conservazione" e, attraverso il supporto di documenti originali e nuove traduzioni, evidenzia il contributo fondamentale di George Gilbert Scott nella riformulazione conservativa degli obiettivi del restauro degli antichi edifici, con molti riferimenti alle idee di …
De Novo Assembly and Functional Annotation of the Olive (Olea europaea) Transcriptome
2013
Olive breeding programmes are focused on selecting for traits as short juvenile period, plant architecture suited for mechanical harvest, or oil characteristics, including fatty acid composition, phenolic, and volatile compounds to suit new markets. Understanding the molecular basis of these characteristics and improving the efficiency of such breeding programmes require the development of genomic information and tools. However, despite its economic relevance, genomic information on olive or closely related species is still scarce. We have applied Sanger and 454 pyrosequencing technologies to generate close to 2 million reads from 12 cDNA libraries obtained from the Picual, Arbequina, and L…
Heteroaromatic Inhibitors of the Astacin Proteinases Meprin α, Meprin β and Ovastacin Discovered by a Scaffold-Hopping Approach.
2020
Abstract Astacin metalloproteinases, in particular meprins α and β, as well as ovastacin, are emerging drug targets. Drug‐discovery efforts have led to the development of the first potent and selective inhibitors in the last few years. However, the most recent compounds are based on a highly flexible tertiary amine scaffold that could cause metabolic liabilities or decreased potency due to the entropic penalty upon binding to the target. Thus, the aim of this study was to discover novel conformationally constrained scaffolds as starting points for further inhibitor optimization. Shifting from flexible tertiary amines to rigid heteroaromatic cores resulted in a boost in inhibitory activity. …
(S)-2-[(2-Hydroxybenzyl)azaniumyl]-4-(methylsulfanyl)butanoate
2011
The zwitterionic title compound, C12H17NO3S, is a reduced Schiff base derived from (S)-N-(2-hydroxybenzylidene)methionine. An intramolecular interaction between the N—H and carboxylate groups forms a roughly planar (r.m.s. deviation = 0.1405 Å) five-membered ring containing the H(N), N, Cα, C(carboxylate) and O atoms in a pentagonal conformation. In the crystal, a supramolecular triangle-shaped motif is generated by molecules held together by O—H...O and N—H...O hydrogen bonds.
Activity typologies as a design model for the ubiquitous detection of daily routines
2018
Emerging technologies open up new visions and business potential for systems design and development in the areas of wellbeing and health. New technologies enable the detection of human performance and early changes in physical and cognitive functioning, making it possible to monitor an older person’s wellbeing. This kind of technology or service sets significant requirements for design, as design concepts must be able to capture the complexity of people’s daily lives in terms of activities and environments. Technology itself is “blind” unless designers can adapt it to human life. There is thus a distinct need for comprehensive design and development models that generate adequate human requi…
Evolution and functional differentiation of recently diverged phytochelatin synthase genes from Arundo donax L.
2019
Plant phytochelatin synthases undergo evolutionarily rapid functional differentiation after duplication, allowing fast and precise adjustment of metal detoxification capacity by modulation of both transcription and enzymatic activity.
DIO SALVI IL RESTAURO. L’apporto inglese alla cultura della conservazione dei monumenti
2020
Sebbene già riuscissimo a percepire quanto rilevante fosse l’apporto inglese per aver contribuito alla definizione del restauro modernamente inteso, sino ad oggi mancavano ancora sia una chiara visione d’insieme delle articolate vicende connesse all'affermazione dei princìpi conservativi, sia una più approfondita conoscenza delle fonti documentarie, necessarie al fine di tracciare i profili culturali dei protagonisti e scandagliarne i contributi teorici. La ricostruzione delle vicende è sviluppata entro margini temporali estesi all'incirca per tre secoli, dalla fine del Seicento al principio del Nove-cento, e strutturata attraverso la traduzione e lo studio di testi perlopiù mai circolati i…
Considerazioni sulla finanza pubblica italiana tra il XIX ed il XX secolo
2015
This essay deals with the doctrinal debate emerging from articles and editorials by econoil mists published on newspapers such as Corriere della Sera, Il Giornale d'Italia, Il Sole, La Tribuna, Il Mattino, Il Secolo. The debate increased interest in items of public finance from 1890 to the rise of fascism in Italy. During thirty years, public debt, tax reform, fiscal matters, finance during war-time and problems relating to rail transport were the main debated topics. These issues show the economic and financial structure of the country in order to better understand the development opportunities which Italy enjoyed introducing the reform necessary to modernize the economic framework.
Sosiaalialan asiakastietojärjestelmissä paljon parannettavaa: käyttäjäkokemukset 2019
2020
Sosiaali- ja terveydenhuollon digitalisaatiolle on asetettu paljon odotuksia niin palveluiden laadun, saavutettavuuden kuin tehokkuuden osalta. Asiakas- ja potilastietojärjestelmiltä odotetaan paljon tavoitteiden saavuttamiseksi. Asiakastietojärjestelmät ovat laajasti käytössä sosiaalialalla, mutta niiden käyttöä työvälineenä ja niiden avulla saavutettuja hyötyjä on tutkittu ammattilaisten näkökulmasta vain vähän. Keväällä 2019 kartoitettiin ensimmäistä kertaa valtakunnallisesti sosiaalialan ammattilaisten käyttäjäkokemuksia asiakastietojärjestelmistä. Tässä artikkelissa kuvataan kyselytutkimuksen toteutus ja tulokset eniten käytettyjen tuotemerkkien osalta. Tutkimus toimii pilottina vuonna…