Search results for "Parallel"

showing 10 items of 667 documents

Pan-cancer analysis of whole genomes

2020

Publisher's version (útgefin grein)

Maletert promoter mutationsCancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2]DNA Mutational AnalysisNormal tissuesystematic analysisGermlineTranscriptome0302 clinical medicineAetiologyCàncerCellular SenescenceCancer0303 health sciencesdna-damageMassive parallel sequencingPan cancerREARRANGEMENTSHigh-Throughput Nucleotide SequencingGenomicsSciences bio-médicales et agricolesTelomereCOMPREHENSIVE3. Good healthTERT PROMOTER MUTATIONSsignatures030220 oncology & carcinogenesisScience & Technology - Other TopicsErfðarannsóknirHuman:Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC]EvolutionRNA SplicingGenomicsArticleEvolution MolecularStructural variationRC025403 medical and health sciencesSDG 3 - Good Health and Well-beingGeneticgenomicsSYSTEMATIC ANALYSISGeneticsGenomics--Databases.HumansGenetic TestingMolecular BiologySIGNATURESWhole genome sequencing1000 MultidisciplinaryChromothripsisScience & TechnologyRC0254 Neoplasms. Tumors. Oncology (including Cancer)Information DisseminationResearchInstitutes_Networks_Beacons/mcrcPreventionBiology and Life SciencesMolecularOncogenesCloud Computingmedicine.diseaseGenòmicaCompute cloudsMutation570 Life sciences; biologyCOMPREHENSIVE CHARACTERIZATIONGenèticaWhole Genome Sequencing--methodsBackground informationDNA Mutational Analysis ; Evolution ; Genetic / genetics ; Genome ; Genomics ; Germ-Line Mutation / genetics ; High-Throughput Nucleotide Sequencing ; Human / genetics ; Humans ; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes ConsortiumMedizinGenomeWhole-genomeGenome mappingNeoplasms2.1 Biological and endogenous factorsPromoter Regions GeneticCàncer -- Aspectes genèticsTelomeraseGeneticsWomen's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17]MultidisciplinaryChromothripsisGenomeManchester Cancer Research Centregenomics cancer profiling3rd-DAS10124 Institute of Molecular Life SciencesWomen's cancers Radboud Institute for Health Sciences [Radboudumc 17]Multidisciplinary SciencesParallel sequencingICGC/TCGA Pan-Cancer Analysis of Whole Genomes ConsortiumFemaleprofilingMedical GeneticsEngineering sciences. TechnologyBiotechnologyGeneral Science & TechnologyThe Cancer Genome Atlas610 Medicine & healthComputational biologyQH426 GeneticsBiologyConsortium of the International Cancer Genome ConsortiumPromoter RegionsGermline mutationPan-cancer analysisKrabbameinsrannsóknirmedicinecancerddc:610QH426Germ-Line MutationMedicinsk genetikKrabbamein030304 developmental biologyCell ProliferationLANDSCAPEGenome Humancomprehensive characterizationPan-cancer analysis of whole genomesPoint mutationHuman GenomeCancerReproducibility of ResultsSOMATIC MUTATIONSEVOLUTIONCancer sequencing Chromothripsis telomereDNA-DAMAGEMutagenesisPATTERNS3111 BiomedicineCHARACTERIZATION
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Non-reversible Monte Carlo simulations of spin models

2011

Abstract Monte Carlo simulations are used to study simple systems where the underlying Markov chain satisfies the necessary condition of global balance but does not obey the more restrictive condition of detailed balance. Here, we show that non-reversible Markov chains can be set up that generate correct stationary distributions, but reduce or eliminate the diffusive motion in phase space typical of the usual Monte Carlo dynamics. Our approach is based on splitting the dynamics into a set of replicas with each replica representing a biased movement in reaction-coordinate space. This introduction of an additional bias in a given replica is compensated for by choosing an appropriate dynamics …

Markov chainMonte Carlo methodGeneral Physics and AstronomyDetailed balanceMarkov chain Monte Carlosymbols.namesakeHardware and ArchitecturesymbolsIsing modelStatistical physicsParallel temperingCritical exponentMathematicsMonte Carlo molecular modelingComputer Physics Communications
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Circular Dichroism of DNA G-Quadruplexes: Combining Modeling and Spectroscopy To Unravel Complex Structures

2016

We report on the comparison between the computational and experimental determination of electronic circular dichroism spectra of different guanine quadruplexes obtained from human telomeric sequences. In particular the difference between parallel, antiparallel, and hybrid structures is evidenced, as well as the induction of transitions between the polymorphs depending on the solution environment. Extensive molecular dynamics simulations (MD) are used to probe the conformational space of the different quadruplexes, and subsequently state-of-the-art hybrid quantum mechanics/molecular mechanics (QM/MM) techniques coupled with excitonic semiempirical Hamiltonian are used to simulate the macromo…

Materials Chemistry2506 Metals and Alloys0301 basic medicineCircular dichroismSurfaces Coatings and FilmNanotechnologyMolecular Dynamics Simulation010402 general chemistryG-quadruplexAntiparallel (biochemistry)01 natural sciencesMolecular mechanics03 medical and health sciencesMolecular dynamicschemistry.chemical_compoundG-QuadruplexeMaterials ChemistryHumans[CHIM]Chemical SciencesPhysical and Theoretical ChemistrySpectroscopyComputingMilieux_MISCELLANEOUSPhysicsQuantitative Biology::BiomoleculesCircular DichroismDNA0104 chemical sciencesSurfaces Coatings and FilmsG-Quadruplexes030104 developmental biologychemistrySettore CHIM/03 - Chimica Generale E InorganicaChemical physicsNucleic Acid ConformationQuantum TheoryDNAHumanMacromoleculeThe Journal of Physical Chemistry B
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Simulation of Models for the Glass Transition: Is There Progress?

2002

The glass transition of supercooled fluids is a particular challenge for computer simulation, because the (longest) relaxation times increase by about 15 decades upon approaching the transition temperature T g. Brute-force molecular dynamics simulations, as presented here for molten SiO2 and coarse-grained bead-spring models of polymer chains, can yield very useful insight about the first few decades of this slowing down. Hence this allows to access the temperature range around T c of the so-called mode coupling theory, whereas the dynamics around the experimental glass transition is completely out of reach. While methods such as “parallel tempering” improve the situation somewhat, a method…

Materials scienceCondensed matter physicsSpinsTransition temperatureMode couplingThermodynamic limitRelaxation (physics)Parallel temperingGlass transitionSupercooling
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Photorefractive detection of antiparallel ferroelectric domains in BaTiO 3 and BaTiO 3 :Co crystals

1998

An all-optical method involving one coherent beam of light and based on photorefractive wave mixing is used to reveal antiparallel ferroelectric domains in one pure, and two cobalt-doped, barium titanate crystals (BaTiO 3 ). Rod-shaped domains with square cross sections are revealed.

Materials scienceCondensed matter physicsbusiness.industryPhysics::OpticsGeneral ChemistryPhotorefractive effectFerroelectricityCondensed Matter::Materials Sciencechemistry.chemical_compoundOpticschemistryCondensed Matter::SuperconductivityBarium titanateLight beamGeneral Materials SciencebusinessMixing (physics)Antiparallel (electronics)Applied Physics A: Materials Science & Processing
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Columnar phases from semi-discoid molecules. Phase induction via hydrogen bonding and charge transfer interactions

1991

Abstract To investigate the non-linear optical properties of nitrophenylhydrazones, a series of 4-nitro- and 2,4-dinitrophenylhydrazones of substituted aromatic aldehydes were synthesized. It was found that many of the dinitrophenythydrazone derivatives are liquid-crystalline and X-ray investigations show that the mesophase corresponds to a hexagonal columnar structure. To explain this unusual behaviour it is necessary to assume that a mesogenic structure is formed by intramolecular hydrogen bonding of the dinitrophenylhydrazones. Charge transfer induced antiparallel alignment of these moleculer dipoles leads to discoid structures, forming the columnar phases.

Materials scienceHydrogen bondMesogenMesophaseGeneral ChemistryCondensed Matter PhysicsAntiparallel (biochemistry)CrystallographyLiquid crystalIntramolecular forceMoleculeOrganic chemistryGeneral Materials ScienceColumnar phaseLiquid Crystals
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Noncovalent force spectroscopy using wide-field optical and diamond-based magnetic imaging

2019

A realization of the force-induced remnant magnetization spectroscopy (FIRMS) technique of specific biomolecular binding is presented where detection is accomplished with wide-field optical and diamond-based magnetometry using an ensemble of nitrogen-vacancy (NV) color centers. The technique may be adapted for massively parallel screening of arrays of nanoscale samples.

Materials sciencePhysics - Instrumentation and DetectorsMagnetometerFOS: Physical sciencesGeneral Physics and AstronomyApplied Physics (physics.app-ph)02 engineering and technologyengineering.material01 natural scienceslaw.inventionMagnetizationlaw0103 physical sciencesPhysics - Biological PhysicsSpectroscopyMassively parallelNanoscopic scale010302 applied physicsQuantum Physicsbusiness.industryForce spectroscopyDiamondInstrumentation and Detectors (physics.ins-det)Physics - Applied Physics021001 nanoscience & nanotechnology3. Good healthBiological Physics (physics.bio-ph)engineeringOptoelectronicsQuantum Physics (quant-ph)0210 nano-technologybusinessRealization (systems)
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Fracture resistance of tooth restored with four glass fiber post systems of varying surface geometries-An in vitro study

2016

Background The purpose of this study was to relate the fracture resistance of endodontically treated teeth in relation to post geometry. Material and methods Forty single rooted mandibular premolars were instrumented by step - back technique and obturated by lateral condensation. Forty teeth were randomly divided into four groups: Reforpost glass fiber X-ray®, RelyX®, Exacto conical® and Parapost Fiber Lux®. The post spaces were prepared using respective drills and luted. The core build up was done and metal crowns were luted. Fracture resistance was determined in universal testing machine. The statistical analysis was done using one way ANOVA and post hoc Tukey Kramer test. Results The tee…

Materials sciencePost hoc0206 medical engineeringGlass fiberDentistryOdontología02 engineering and technologyLateral condensationOperative Dentistry and Endodontics03 medical and health sciences0302 clinical medicinestomatognathic systemIn vitro studyStatistical analysisGeneral DentistryUniversal testing machinebusiness.industryParallel designResearch030206 dentistry:CIENCIAS MÉDICAS [UNESCO]020601 biomedical engineeringCiencias de la saludstomatognathic diseasesUNESCO::CIENCIAS MÉDICASFracture (geology)businessJournal of Clinical and Experimental Dentistry
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Analysis of multipactor RF breakdown in a waveguide containing a transversely magnetized ferrite

2016

In this paper, the multipactor RF breakdown in a parallel-plate waveguide partially filled with a ferrite slab magnetized normal to the metallic plates is studied. An external magnetic field is applied along the vertical direction between the plates in order to magnetize the ferrite. Numerical simulations using an in-house 3-D code are carried out to obtain the multipactor RF voltage threshold in this kind of structures. The presented results show that the multipactor RF voltage threshold at certain frequencies becomes considerably lower than for the corresponding classical metallic parallel-plate waveguide with the same vacuum gap

Materials scienceSaturation magnetizationElectromagnetic waveguidesPhysics::Instrumentation and DetectorsIn-house 3D codeTransversely magnetized ferrite01 natural sciencesVacuum gap010305 fluids & plasmasExternal magnetic fieldOptics0103 physical sciencesVertical directionRadio frequencyTEORIA DE LA SEÑAL Y COMUNICACIONESParallel-plate waveguideElectronic engineeringNumerical simulationsElectrical and Electronic EngineeringMagnetic anisotropyElectric breakdownMultipactor RF breakdown analysis010302 applied physicsbusiness.industryParallel plate waveguidesFerrite slabRF breakdownMicrowave switchesVacuum gapElectronic Optical and Magnetic MaterialsMagnetic fieldMultipactor RF voltage thresholdMagnetic fieldMetallic platesMagnetic fieldsSlabFerrite (magnet)Ferrite waveguidesFerrite devicesMultipactor effectbusinessVoltageNumerical analysis
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Carrier transport mechanism in the SnO(2):F/p-type a-Si:H heterojunction

2011

We characterize SnO(2):F/p-type a-Si:H/Mo structures by current-voltage (I-V) and capacitance-voltage (C-V) measurements at different temperatures to determine the transport mechanism in the SnO2:F/p-type a-Si:H heterojunction. The experimental I-V curves of these structures, almost symmetric around the origin, are ohmic for vertical bar V vertical bar< 0:1 V and have a super-linear behavior (power law) for vertical bar V vertical bar < 0:1 V. The structure can be modeled as two diodes back to back connected so that the main current transport mechanisms are due to the reverse current of the diodes. To explain the measured C-V curves, the capacitance of the heterostructure is modeled as the …

Materials scienceTunnel junctionAnalytical chemistryGeneral Physics and AstronomyHeterojunctionSeries and parallel circuitsOhmic contactMolecular physicsPower lawCapacitancefluorinated tin oxide amorphous silicon tunnel-junction C-V profiling modeling.Quantum tunnellingDiode
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