Search results for "Paralysis"
showing 10 items of 78 documents
Drug‐refractory myasthenia gravis: Clinical characteristics, treatments, and outcome
2022
[Objective] To describe the clinical characteristics and outcomes in patients with refractory myasthenia gravis (MG) and to determine the effectiveness and side effects of the drugs used for their treatment.
Two cases of adynamia episodica hereditaria: In vitro investigation of muscle cell membrane and contraction parameters
1983
Membrane potentials, current-voltage relationships, and contractile parameters were studied in intact muscle cell bundles obtained from two patients with adynamia episodica hereditaria. In a normal extracellular medium, the cell membranes had resting potentials of about -80 mV and their current-voltage relationships were not significantly different from control curves. In contrast to normal muscles the afflicted cells were paralyzed in a medium having 6-10 mmol/liter potassium. The mechanisms of paralysis in the two specimens were different from each other. Many fibers from one patient were spontaneously active even in normal solution. In high potassium solution spontaneous activity was inc…
Isolated superior oblique palsies with electrophysiologically documented brainstem lesions
2000
Over a 13.5-year period, we observed 10 patients with isolated superior oblique palsies in whom electrophysiological abnormalities indicated brainstem lesions. In 7 patients unilateral masseter reflex abnormalities were seen, and were located on the side of the superior oblique palsy in 2 patients and on the opposite side in 5 patients. Two patients had slowed gain of following eye movements to the side contralateral to the superior oblique palsy. Slowed adduction saccades in the eye contralateral to the superior oblique palsy were seen in 1 patient. Clinical improvement was frequently (in 7 of 10 patients) associated with improvement or normalization of electrophysiologic findings. Magneti…
Carcinoma of the tongue and bulbar-onset amyotrophic lateral sclerosis: unusual differential diagnosis.
2007
We present a 72-year-old woman with progressive dysphagia, dysarthria and tongue palsy who was initially diagnosed with bulbar-onset amyotrophic lateral sclerosis (ALS). However, the absence of atrophy or fasciculations in the tongue, as in other voluntary muscles, and the lack of reproducible neurophysiological evidence of denervation, prompted a revision of the diagnostic work-up, which eventually led to the discovery of a carcinoma of the tongue. This case report describes a relatively rare type of oropharyngeal carcinoma that, in its early stage, resembled a bulbar-onset ALS. This differential diagnosis is unusual, and it was fostered by the persistent lack of atrophy of the tongue and …
Chapter 35 Transcranial magnetic stimulation in brainstem lesions and lesions of the cranial nerves
2003
Publisher Summary This chapter focuses on transcranial magnetic stimulation (TMS) applications in brainstem pathology and on the description of TMS techniques for the evaluation of motor cranial nerve function, which is an essential measure in the diagnostic workup of brain-stern lesions. Applications of TMS to the cranial nerve innervated muscles have been the objective of numerous investigations, ranging from basic neuroanatomic studies to determine the central course of corticonuclear projections to clinical applications carried out to determine the location of lesions, investigate the pathophysiology of ischemic dysarthria, detect clinically silent lesions in multiple sclerosis, obtain …
Data from 235 Cases of Bell's Palsy during COVID-19 Pandemic: Were There Clusters of Facial Palsy?
2021
Sin financiación 5.393 JCR (2021) Q1, 49/212 Clinical Neurology 1.204 SJR (2021) Q1, 79/378 Neurology (clinical) No data IDR 2020 UEM
Le corps vécu et l’expérience du handicap
2008
RésuméCet article fait état d’un dialogue avec M. Marcel Nuss, atteint depuis l’enfance d’une grave amyotrophie spinale, à propos de l’expérience du corps vécu. Il s’agit d’abord de décrire la manière dont une personne ordinaire ressent son corps, notamment par l’intermédiaire de la phénoménologie de Maurice Merleau-Ponty, puis de confronter certaines hypothèses à l’expérience d’une personne en situation de handicap. Le corps vécu ou corps propre désigne ici une expérience consciente du corps comme puissance d’action au sens de Merleau-Ponty, comme enveloppe corporelle au sens de D. Anzieu, enfin comme unité proprioceptive. Nous nous demanderons dans quelle mesure nous pouvons approcher l’e…
Effect of unilateral diaphragmatic paralysis on postpneumonectomy lung growth.
2013
Respiratory muscle-associated stretch has been implicated in normal lung development (fetal breathing movements) and postpneumonectomy lung growth. To test the hypothesis that mechanical stretch from diaphragmatic contraction contributes to lung growth, we performed left phrenic nerve transections (PNT) in mice with and without ipsilateral pneumonectomy. PNT was demonstrated by asymmetric costal margin excursion and confirmed at autopsy. In mice with two lungs, PNT was associated with a decrease in ipsilateral lung volume ( P < 0.05) and lung weight ( P < 0.05). After pneumonectomy, PNT was not associated with a change in activity level, measureable hypoxemia, or altered minute venti…
Surgical complications in prophylactic central neck dissection: Preliminary findings from a retrospective cohort study
2014
Aim. Papillary thyroid carcinoma (PTC) is the most frequent thyroid malignancy with an overall ten-year survival more than 90%. Total thyroidectomy (TT) is considered the gold standard for PTC, but not all the endocrine surgeons agree on central neck dissection except in case of known metastases. Methods. We enrolled 158 patients, that underwent, between January 1990 and September 2012 total thyroidectomy±prophylactic CND for PTC. 59 Patients (group A) had a preoperative diagnosis of PTC; 99 (group B) had a diagnosis of benign disease. We focused on possible complications. Results. In group A we had 4 patients who blamed a definitive RLN palsy, only 1 patient in group B, with an OR=7.12. De…
Phenotypic spectrum and incidence of TRPV4 mutations in patients with inherited axonal neuropathy.
2014
Objective: To clarify the phenotypic spectrum and incidence of TRPV4 mutations in patients with inherited axonal neuropathies. Methods: We screened for TRPV4 mutations in 169 French unrelated patients with inherited axonal peripheral neuropathy. Ninety-five patients had dominant Charcot-Marie-Tooth type 2 (CMT2) disease, and 74 patients, including 39 patients with distal hereditary motor neuropathy, 14 with congenital spinal muscular atrophy and arthrogryposis, 13 with CMT2, and 8 with scapuloperoneal spinal muscular atrophy, presented with additional vocal cord paralysis and/or skeletal dysplasia. Results: No deleterious TRPV4 mutation was identified in the 95 patients with “pure” CMT2 (0/…