Search results for "Parametric"
showing 10 items of 980 documents
Relationship between airway sensitivity to adenosine 5' monophosphate and the shape of the concentration-response curve to methacholine in subjects w…
2001
Abstract The objective of this study was to determine differences in airway sensitivity to adenosine 5′-monophosphate (AMP) between allergic rhinitis subjects with plateau and those without evidence of plateau on the concentration–response curves to methacholine. A total of 51 adults (38 subjects with allergic rhinitis and 13 healthy controls) were challenged with increasing concentrations of methacholine and AMP. The methacholine challenge was terminated when there was a 40% or more decrease in forced expiratory volume in 1 sec (FEV 1 ), whereas the AMP challenge was stopped when FEV 1 had fallen by more than 20%. A plateau for methacholine was detected in all 13 healthy controls and in 27…
Retrograde in situ versus antegrade pulmonary preservation in clinical lung transplantation: a single-centre experience.
2014
OBJECTIVE Experimental and clinical studies have indicated a beneficial effect of retrograde lung preservation on post-transplant results. Accordingly, we conducted a non-randomized trial. METHODS A total of 209 consecutive recipients transplanted with low-potassium dextrane (LPD)-preserved lungs were eligible for analysis. Antegrade lung preservation (AP) was performed in 173 patients and retrograde in situ perfusion (RP) in 36 patients using low-potassium dextrane solution in all cases. The prostacycline was added to preservation solution. RESULTS The main donor, graft and recipient characteristics did not differ significantly between groups. There was a beneficial trend toward improved o…
Elevation of total serum immunoglobulin E is associated with asthma in nonallergic individuals.
2000
Elevated serum immunoglobulin (Ig)E is the hallmark of atopy, and contributes to asthma and bronchial hyperresponsiveness in atopic individuals. In contrast, the significance of IgE in nonallergic subjects is less clear. The aim of the present study is to clarify a potential association of IgE and asthma in absence of clinical allergy. To this purpose 1,219 consecutive patients of a pulmonary practice were evaluated. Nonallergic patients were defined by negative skin prick test, history of atopy and specific IgE, 509 subjects (42%) were nonallergic. Among these, 80 patients (16%) had elevated total IgE levels (150 U x mL(-1)). Prevalence and severity of asthma in nonallergic subjects with I…
TLR4 Up-regulation and Reduced Foxp3 Expression in Mechanically Ventilated Smokers with Obstructive Chronic Bronchitis
2013
Background: Chronic bronchitis (CB) is a risk factor in chronic obstructive pulmonary disease (COPD) for accelerated lung function decline and increased mortality. The lung and systemic inflammatory and immunological profile of COPD patients with CB which acutely experience respiratory failure upon a disease exacerbation is unknown. Methods: In this study, we explored the expression of Foxp3 by western blot analysis, TLR4 by immunocytochemistry and the concentrations of IP-10 and IL-8 by ELISA in the mini-bronchoalveolar lavages (mini-BAL) and in the peripheral blood of patients with respiratory failure requiring intubation and mechanical ventilation. The recruited subjects were separated i…
Chronological expression of Ciliated Bronchial Epithelium 1 during pulmonary development
2009
Ciliated Bronchial Epithelium (CBE) 1 is a novel gene, which is expressed in ciliated cells. As cilia are important during embryogenesis, the present authors characterised the murine homologue of CBE1 (Cbe1) and compared its temporal expression during murine and human lung development. Cbe1 cDNA was cloned and characterised using sequencing, standard PCR and Western blotting. Mouse and human embryonic/fetal lungs (HELs) were harvested for mRNA analysis and protein localisation in vivo and in vitro using RT-PCR and immunohistochemistry. The Cbe1 amino acid sequence was >75% identical with CBE1 and its alternative splicing and tissue distribution were highly conserved. Pulmonary expression of…
Parameter dependence for the positive solutions of nonlinear, nonhomogeneous Robin problems
2020
We consider a parametric nonlinear Robin problem driven by a nonlinear nonhomogeneous differential operator plus an indefinite potential. The reaction term is $$(p-1)$$-superlinear but need not satisfy the usual Ambrosetti–Rabinowitz condition. We look for positive solutions and prove a bifurcation-type result for the set of positive solutions as the parameter $$\lambda >0$$ varies. Also we prove the existence of a minimal positive solution $$u_\lambda ^*$$ and determine the monotonicity and continuity properties of the map $$\lambda \rightarrow u_\lambda ^*$$.
Multiple Solutions with Sign Information for a Class of Coercive (p, 2)-Equations
2019
We consider a nonlinear Dirichlet equation driven by the sum of a p-Laplacian and of a Laplacian (a (p, 2)-equation). The hypotheses on the reaction f(z, x) are minimal and make the energy (Euler) functional of the problem coercive. We prove two multiplicity theorems producing three and four nontrivial smooth solutions, respectively, all with sign information. We apply our multiplicity results to the particular case of a class of parametric (p, 2)-equations.
Positive solutions for the Neumann p-Laplacian
2017
We examine parametric nonlinear Neumann problems driven by the p-Laplacian with asymptotically ( $$p-1$$ )-linear reaction term f(z, x) (as $$x\rightarrow +\infty $$ ). We determine the existence, nonexistence and minimality of positive solutions as the parameter $$\lambda >0$$ varies.
A multiplicity theorem for parametric superlinear (p,q)-equations
2020
We consider a parametric nonlinear Robin problem driven by the sum of a \(p\)-Laplacian and of a \(q\)-Laplacian (\((p,q)\)-equation). The reaction term is \((p-1)\)-superlinear but need not satisfy the Ambrosetti-Rabinowitz condition. Using variational tools, together with truncation and comparison techniques and critical groups, we show that for all small values of the parameter, the problem has at least five nontrivial smooth solutions, all with sign information.
Génération et interfaçage de lumière à photon unique et contrôle de la dynamique atomique ultra-rapide pour l’information quantique
2010
We develop a robust and realistic mechanism for the generation of indistinguishable single-photon (SP) pulses with identical frequency and polarization. They are produced on demand from a coupled double-Raman atom-cavity system driven by a sequence of laser pump pulses. This scheme features a high efficiency, the ability to produce a sequence of narrow-band SP pulses with a delay determined only by the pump repetition rate, and simplicity of the system free from complications such as repumping process and environmental dephasing. We propose and analyze a simple scheme of parametric frequency conversion for optical quantum information in cold atomic ensembles. Its remarkable properties are m…