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showing 10 items of 1549 documents

Predictors of complications and mortality following left colectomy with primary stapled anastomosis for cancer: results of a multicentric study with …

2018

Aim Reports detailing the morbidity-mortality after left colectomy are sparse and do not allow definitive conclusions to be drawn. We aimed to identify risk factors for anastomotic leakage, perioperative mortality and complications following left colectomy for colonic malignancies. Method We undertook a STROBE-compliant analysis of left colectomies included in a national prospective online database. Forty-two variables were analysed as potential independent risk factors for anastomotic leakage, postoperative morbidity and mortality. Variables were selected using the 'least absolute shrinkage and selection operator' (LASSO) method. Results We analysed 1111 patients. Eight per cent of patient…

Malemedicine.medical_specialtyColectomiesDatabases FactualColorectal cancerColonanastomotic leak030230 surgeryLower risk03 medical and health sciencesLiver disease0302 clinical medicineRisk FactorsSurgical StaplingmedicineHumansstapled anastomosipostoperative complicationProspective Studiesleft colectomyColectomyAgedbusiness.industryAnastomosis SurgicalGastroenterologyPostoperative complicationPerioperativeMiddle Agedmedicine.diseaseSurgeryColon cancerParenteral nutritionTreatment Outcome030220 oncology & carcinogenesisColonic NeoplasmsFemalebusinessComplication
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Parental support, family conflict, and overprotectiveness: Predicting PTSD symptom levels of adolescents 28 months after a natural disaster

2008

The purpose of this study was to evaluate the role of family factors as predictors of posttraumatic stress disorder (PTSD) symptoms among adolescents, a substantial period of time after a natural disaster. It was hypothesized that a lack of parental support, family conflict, and overprotectiveness are all risk factors with regard to levels of PTSD symptoms. A group of 533 schoolchildren and high-school students was investigated 28 months after a huge flood, which was one of the most devastating disasters in Poland. The results of a hierarchical regression analysis indicate that the extent of traumatic exposure, parental support, family conflict, and overprotectiveness, all predicted levels …

Malemedicine.medical_specialtyCoping (psychology)AdolescentPoison controlSuicide preventionConflict PsychologicalDisastersStress Disorders Post-TraumaticSocial supportArts and Humanities (miscellaneous)Risk FactorsInjury preventionDevelopmental and Educational PsychologymedicineHumansFamilyPsychiatryParentingSocial SupportSocial environmentHuman factors and ergonomicsmedicine.diseasePsychiatry and Mental healthClinical PsychologyRegression AnalysisFemalePolandPsychologyAnxiety disorderAnxiety, Stress & Coping
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Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood

2019

<b><i>Background:</i></b> Little is known about the association between adrenarche and cognition in general populations of children. We therefore studied the associations of dehydroepiandrosterone sulfate (DHEAS), androstenedione (A4), testosterone, insulin-like growth factor-1 (IGF-1), and adrenarche with cognition among prepubertal children. <b><i>Methods:</i></b> These cross-sectional analyses are based on baseline data of the Physical Activity and Nutrition in Children Study. A total of 387 children (183 girls, 204 boys) were included in the analyses. Raven’s Coloured Progressive Matrices (CPM) score was used to assess nonverbal reasoning.…

Malemedicine.medical_specialtyEndocrinology Diabetes and Metabolism030209 endocrinology & metabolism03 medical and health scienceschemistry.chemical_compoundCognition0302 clinical medicineEndocrinologyDehydroepiandrosterone sulfateRaven's Progressive MatricesParental educationInternal medicineHumansMedicineTestosteroneAndrostenedioneInsulin-Like Growth Factor IChildTestosterone030219 obstetrics & reproductive medicinebusiness.industryAdrenarcheAge FactorsAndrostenedioneCognitionDehydroepiandrosteroneBaseline dataEndocrinologychemistryPediatrics Perinatology and Child HealthFemalebusinessHormone Research in Paediatrics
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Neonatal liver abscesses associated with candidemia: three cases and review of literature.

2014

Abstract BACKGROUND: Our aim was to identify risk factors for the development of neonatal Candida liver abscess and to find useful information to better manage this potentially fatal complication. METHODS: A computerized search was conducted using PubMed. Overall, three articles describing the history of seven infants were finally considered. The characteristics of these seven cases were analyzed together with those of three new cases that we treated in the recent past. RESULTS: All the neonates were premature. Previous antibiotic use was reported in all the cases, umbilical venous catheterization in 9/10 and total parenteral nutrition in 8/10. Candida albicans was isolated in 9/10. All the…

Malemedicine.medical_specialtyLiver AbscessMEDLINEInfant Premature DiseasesCandida; Candidemia; Liver abscess; Preterm infantSepsismedicineHumansAntibiotic useCandida albicansbiologybusiness.industryInfant NewbornObstetrics and GynecologyCandidemiamedicine.diseasebiology.organism_classificationSurgeryParenteral nutritionSolitary lesionCandida Candidemia Liver abscessPediatrics Perinatology and Child HealthFemaleUltrasonographybusinessInfant PrematureLiver abscessThe journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
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Potential Myocardial Iron Content Evaluation by Magnetic Resonance Imaging in Thalassemia Major Patients Treated with Deferoxamine or Deferiprone Dur…

2003

The purpose of this study was to evaluate if the variations of heart magnetic resonance imaging in beta-thalassemia major patients treated with Deferoxamine B mesylate (DF) or Deferiprone (L1) chelation therapy is a useful tool of the indirect myocardial iron content determination. For this reason, a prospective study was carried out. Seventy-two consecutive patients with beta-thalassemia major (35 treated with DF and 37 with L1) were studied. The main outcome results were laboratory parameters including determination of the liver iron concentration (LIC) and magnetic resonance imaging (MRI) of the heart and liver. The heart to muscle signal intensity ratios (HSIRs) were significantly incre…

Malemedicine.medical_specialtyLiver Iron ConcentrationPyridonesIronThalassemiaClinical BiochemistryAdministration OralDeferoxamineIron Chelating AgentsGastroenterologychemistry.chemical_compoundInternal medicinemedicineHumansDeferiproneInfusions ParenteralChelation therapyProspective cohort studyGenetics (clinical)medicine.diagnostic_testbusiness.industryMyocardiumbeta-ThalassemiaBiochemistry (medical)Beta thalassemiaMagnetic resonance imagingHematologymedicine.diseaseMagnetic Resonance ImagingDeferoxaminechemistryHeart Function TestsPatient ComplianceFemalebusinessDeferipronemedicine.drugHemoglobin
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Hepatic extraction of isosorbide dinitrate in cardiac patients

1983

Hepatic extraction of organic nitrates, including that of isosorbide dinitrate (ISDN), has been thought to be nearly complete in man but has never been directly measured. We examined the time course of plasma ISDN and metabolite concentrations in arterial and hepatic venous blood in four cardiac patients receiving an intravenous ISDN infusion. Apparent hepatic extraction of ISDN was high (90%) at the beginning of infusion but fell to about 44% 1 hr after termination of infusion. The decrease in ISDN concentration gradient across the liver correlates with an increase in plasma isosorbide-5-mononitrate concentration, but a cause-and-effect relationship resulting from metabolite inhibition can…

Malemedicine.medical_specialtyMetaboliteBiological AvailabilityCoronary DiseaseIsosorbide DinitratePharmacologylaw.inventionchemistry.chemical_compoundlawInternal medicineHepatic extractionmedicineHumansInfusions ParenteralPharmacology (medical)In patientPharmacologyClinical pharmacologybusiness.industryVenous bloodMiddle AgedBioavailabilityKineticsEndocrinologyLiverchemistryTime courseIsosorbide dinitratebusinessmedicine.drugClinical Pharmacology and Therapeutics
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Parenteral nutrition improves nutritional status, autonomic symptoms and quality of life in transthyretin amyloid polyneuropathy

2016

Transthyretin familial amyloid polyneuropathy (TTR-FAP) is an inherited amyloidosis, leading to death in about ten years in most cases due to cardiac failure or wasting syndrome. Previous studies showed that modified body mass index was related to time before death, duration of gastrointestinal disturbances, malabsorption and functional capacity. We report two patients in whom nutritional status worsened despite diet modification, hypercaloric supplement and two relevant therapeutic approaches such as liver transplant and tafamidis meglumine, respectively. The first patient, a 52-year-old lady carrying Thr49Ala mutation, had a disease duration of twelve years and had lost weight up to 35 kg…

Malemedicine.medical_specialtyPediatricsMalabsorptionNausea030204 cardiovascular system & hematologyPediatrics03 medical and health sciences0302 clinical medicineQuality of lifeNutritional statusMedicineHumansWasting SyndromeTTR-FAPGenetics (clinical)Amyloid Neuropathies FamilialFamilial amyloid polyneuropathy; Modified body mass index (mBMI); Nutritional status; Parenteral nutrition; TTR-FAP; Neurology (clinical); Pediatrics Perinatology and Child Health; Genetics (clinical); Neurologybiologybusiness.industryAmyloidosisMiddle AgedPerinatology and Child Healthmedicine.diseaseParenteral nutritionSurgeryTransthyretinParenteral nutritionTreatment OutcomeAutonomic Nervous System DiseasesNeurologyFamilial amyloid polyneuropathyPediatrics Perinatology and Child Healthbiology.proteinQuality of LifeFemaleNeurology (clinical)medicine.symptombusinessBody mass index030217 neurology & neurosurgeryModified body mass index (mBMI)
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Depression, Somatization, and Posttraumatic Stress Disorder in Children Born of Occupation After World War II in Comparison With a General Population.

2015

At the end of World War II and during the first decade after the war, roughly 200,000 children were fathered in intimate contacts between German women and foreign soldiers. The experiences of these German occupation children (GOC) have been so far described in case reports and from historical perspective only. Research on psychosocial consequences of growing up as a GOC has been missing so far. This study examined traumatic experiences, posttraumatic stress disorder, somatization, and depression in GOC (N = 146) using self-report instruments: Posttraumatic Diagnostic Scale and Patient Health Questionnaire. Findings have then been compared with a representative birth cohort-matched sample fr…

Malemedicine.medical_specialtyWorld War IIPopulationViolenceGermanStress Disorders Post-TraumaticGermanySurveys and QuestionnairesmedicinePrevalenceHumanseducationPsychiatrySomatoform DisordersPovertyDepression (differential diagnoses)Psychiatric Status Rating Scaleseducation.field_of_studyStereotypingDepressionSingle parentSingle mothersHistory 20th CenturyMiddle Agedmedicine.diseaseComorbiditySingle Parentlanguage.human_languagePsychiatry and Mental healthlanguageFemalePsychologyPsychosocialSomatizationClinical psychologyThe Journal of nervous and mental disease
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Combined medical and mechanical recanalization in acute myocardial infarction

1985

A technique of combined medical and mechanical recanalization was employed in 96 patients with acute transmural myocardial infarction. The mean time between onset of symptoms and admission to hospital was 170 +/- 65 min (X +/- SD). After 10 +/- 16 min, 250,000 U streptokinase was administered intravenously for 20 min. Intracoronary thrombolysis was commenced within 38 +/- 14 min. First coronary angiograms demonstrated reperfusion, an open vessel in 25/96 patients (26%). In 15/71 patients (21%) reperfusion occurred during thrombolysis therapy, before mechanical recanalization could be performed. Recanalization was achieved mechanically in 37/71 patients (52%) with occluded coronary vessels. …

Malemedicine.medical_specialtymedicine.medical_treatmentStreptokinaseMyocardial InfarctionCoronary DiseaseAnterior myocardial infarctionElectrocardiographyRecurrenceCoronary CirculationInternal medicinemedicineHumansInfusions ParenteralStreptokinaseMyocardial infarctionAgedChemotherapybusiness.industryHemodynamicsArrhythmias CardiacStroke VolumeThrombolysisMiddle Agedmedicine.diseaseCombined Modality TherapyMyocardial ContractionPeripheralCoronary vesselCardiologyFemaleCardiology and Cardiovascular MedicinebusinessAngioplasty Balloonmedicine.drugIntracoronary thrombolysisCatheterization and Cardiovascular Diagnosis
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A new type of autosomal recessive spondyloepiphyseal dysplasia tarda

2004

Repeated occurrence of a hitherto unrecognized form of spondyloepiphyseal dysplasia tarda (SED tarda) has been studied in two independent families. Because parental consanguinity was also present in one family, autosomal recessive inheritance is proposed. The onset was in late childhood. The slowly evolving disorder shared several features of the already known types of SED tarda. The radiographic abnormalities were limited to the spine and proximal femora. The patients' hands were normal. The entity described is set apart not only from the X-linked and autosomal-dominant forms of SED tarda but also from the already delineated autosomal recessive types by significant clinical and radiographi…

Malemusculoskeletal diseasesSpondyloepiphyseal dysplasiaSpondyloepiphyseal dysplasia tardamedicine.medical_specialtyAdolescentGenes RecessiveBiologyOsteochondrodysplasiasGenetic linkageMolecular geneticsGenotypemedicineHumansChildGenetics (clinical)Family HealthGeneticsSpondyloepimetaphyseal dysplasiaFemur Headmedicine.diseaseOsteochondrodysplasiaSpineRadiographyParental consanguinityFemaleEpiphysesAmerican Journal of Medical Genetics
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