Search results for "Partial"
showing 10 items of 1477 documents
Coupling between agonist and chloride ionophore sites of the GABA(A) receptor: agonist/antagonist efficacy of 4-PIOL.
2000
Eight gamma-aminobutyric acid (GABA) mimetics were tested on their ability to differentiate native GABA(A) receptor subtypes present in various rat brain regions. In rat brain cryostat sections, little regional variations by the agonistic actions of muscimol, thiomuscimol, 4,5,6,7-tetrahydroisoazolo(5,4-c)pyridin-3-ol, piperidine-4-sulphonic acid, taurine and beta-alanine on [35S]t-butylbicyclophosphorothionate ([35S]TBPS) binding to GABA(A) receptor channels were found. They were very similar to those found for GABA itself and indicated no direct correlation with single subunit distributions for any of these compounds. Only the low-efficacy GABA mimetic 5-(4-piperidyl)isoxazol-3-ol (4-PIOL…
Exploring kainate receptor pharmacology using molecular dynamics simulations.
2010
Ionotropic glutamate receptors (iGluRs) are enticing targets for pharmaceutical research; however, the search for selective ligands is a laborious experimental process. Here we introduce a purely computational procedure as an approach to evaluate ligand–iGluR pharmacology. The ligands are docked into the closed ligand-binding domain and during the molecular dynamics (MD) simulation the bi-lobed interface either opens (partial agonist/antagonist) or stays closed (agonist) according to the properties of the ligand. The procedure is tested with closely related set of analogs of the marine toxin dysiherbaine bound to GluK1 kainate receptor. The modeling is set against the abundant binding data …
Structural Mechanism of N-Methyl-D-Aspartate Receptor Type 1 Partial Agonism
2012
N-methyl-D-aspartate (NMDA) receptors belong to a family of ionotropic glutamate receptors that contribute to the signal transmission in the central nervous system. NMDA receptors are heterotetramers that usually consist of two GluN1 and GluN2 monomers. The extracellular ligand-binding domain (LBD) of a monomer is comprised of discontinuous segments that form the functional domains D1 and D2. While the binding of a full agonist glycine to LBD of GluN1 is linked to cleft closure and subsequent ion-channel opening, partial agonists are known to activate the receptor only sub-maximally. Although the crystal structures of the LBD of related GluA2 receptor explain the mechanism for the partial a…
Research on Acute Toxicity and the Behavioral Effects of Methanolic Extract from Psilocybin Mushrooms and Psilocin in Mice
2015
The pharmacological activities and acute toxicity of the psilocin (PC) and dried residues of the crude extracts of psychotropic mushrooms were investigated in mice. The hallucinogenic substances were effectively isolated, by using methanol, from the species of Psilocybe semilanceata and Pholiotina cyanopus, that were collected in the north-east region of Poland. The chemical analysis of these extracts, which was performed by liquid chromatography with mass spectrometry detection (LC-MS), indicated the presence of psilocin and other hallucinogenic substances, including indolealkylamines and their phosphorylated analogues. When the pure psilocin or fungal extracts were used, slight difference…
Tuning The Selectivity To Aldehyde Via Ph Regulation In The Photocatalytic Oxidation Of 4-Methoxybenzyl Alcohol And Vanillyl Alcohol By Tio2 Catalysts
2021
Abstract The influence of pH on the photocatalytic partial oxidation of 4-methoxybenzyl alcohol (MBA) and vanillyl alcohol (VA) to their corresponding aldehydes in aqueous suspension under UVA irradiation was investigated by using poorly crystalline home-prepared and crystalline commercial TiO2 (BDH, Merck and Degussa P25) photocatalysts. The results clearly show as tuning pH can strongly impart selectivity and activity to photocatalytic processes which are often quite unselective in aqueous suspensions. It was found that pH effect on reaction rate and product selectivity strongly depended on TiO2 crystallinity and substrate type. In the case of MBA oxidation, photoreactivity and selectivit…
On stability issues for IMEX schemes applied to 1D scalar hyperbolic equations with stiff reaction terms
2011
The application of a Method of Lines to a hyperbolic PDE with source terms gives rise to a system of ODEs containing terms that may have very different stiffness properties. In this case, Implicit-Explicit Runge-Kutta (IMEX-RK) schemes are particularly useful as high order time integrators because they allow an explicit handling of the convective terms, which can be discretized using the highly developed shock capturing technology, together with an implicit treatment of the source terms, necessary for stability reasons. Motivated by the structure of the source term in a model problem introduced by LeVeque and Yee in [J. Comput. Phys. 86 (1990)], in this paper we study the preservation of ce…
Multiplicity results for a class of asymmetric weakly coupled systems of second order ordinary differential equations
2005
We prove the existence and multiplicity of solutions to a two-point boundary value problem associated to a weakly coupled system of asymmetric second-order equations. Applying a classical change of variables, we transform the initial problem into an equivalent problem whose solutions can be characterized by their nodal properties. The proof is developed in the framework of the shooting methods and it is based on some estimates on the rotation numbers associated to each component of the solutions to the equivalent system.
On strong solutions of the differential equations modeling the steady flow of certain incompressible generalized Newtonian fluids
2007
In this paper we discuss a system of partial differential equations describing the steady flow of an incompressible fluid and prove the existence of a strong solution under suitable assumptions on the data. In the 2D-case this solution turns out to be of class C^{1,\alpha}.
Existence of dynamical low-rank approximations to parabolic problems
2021
The existence and uniqueness of weak solutions to dynamical low-rank evolution problems for parabolic partial differential equations in two spatial dimensions is shown, covering also non-diagonal diffusion in the elliptic part. The proof is based on a variational time-stepping scheme on the low-rank manifold. Moreover, this scheme is shown to be closely related to practical methods for computing such low-rank evolutions.
Fixed point theorems for fuzzy mappings and applications to ordinary fuzzy differential equations
2014
Abstract Ran and Reurings (Proc. Am. Math. Soc. 132(5):1435-1443, 2004) proved an analog of the Banach contraction principle in metric spaces endowed with a partial order and discussed some applications to matrix equations. The main novelty in the paper of Ran and Reurings involved combining the ideas in the contraction principle with those in the monotone iterative technique. Motivated by this, we present some common fixed point results for a pair of fuzzy mappings satisfying an almost generalized contractive condition in partially ordered complete metric spaces. Also we give some examples and an application to illustrate our results. MSC:46S40, 47H10, 34A70, 54E50.