Search results for "Pathological"

Influence of polysaccharides on wine protein aggregation.

2016

Abstract Polysaccharides are the major high-molecular weight components of wines. In contrast, proteins occur only in small amounts in wine, but contribute to haze formation. The detailed mechanism of aggregation of these proteins, especially in combination with other wine components, remains unclear. This study demonstrates the different aggregation behavior between a buffer and a model wine system by dynamic light scattering. Arabinogalactan-protein, for example, shows an increased aggregation in the model wine system, while in the buffer system a reducing effect is observed. Thus, we could show the importance to examine the behavior of wine additives under conditions close to reality, in…

Cathepsin L in Normal and Pathological Bone Remodeling

2011

Abstract Cathepsin L is a ubiquitous lysosomal cysteine endopeptidase that is mainly involved in the metabolic turnover of intracellular proteins. However, it is now well established that this enzyme may also be implicated in the regulation of other important biological processes includ- ing bone resorption. Therefore, altered expression levels of Cathepsin L may result in disturbances of bone homeo- stasis and, eventually, in the onset of pathological condi- tions associated with altered bone turnover. These observations support the concept that Cathepsin L may be regarded as an additional target for the development of novel therapeutic options for the treatment of patients with bone disea…

Hating Adolescents Test (HAT): a preliminary development of a measure to assess hating among adolescents

2020

The phenomenon of haters is becoming common among adolescents. The aims of the present research were to evaluate the preliminary psychometric properties of the Hating Adolescents Test (HAT), an ad hoc questionnaire created to evaluate online and offline hate (Study 1), and possible risk factors connected with hate (Study 2). Participants (202 female and 200 male) of this study completed the HAT, the How I Think Questionnaire, the Buss–Perry Aggression Questionnaire, and the Penn State Worry Questionnaire. Descriptive statistics were calculated, and exploratory factor analysis and confirmatory factor analysis were applied. Preliminary data suggest how males reported higher level of hate than…

Do patients with pathological health anxiety fear COVID-19? A time-course analysis of 12 single cases during the “first wave” of the COVID-19 pandemi…

2021

Objective Pre-existing health anxiety is associated with an intensified affective response to the novel COVID-19 pandemic in the general population. Still, results on the reaction of people with a diagnosis of pathological health anxiety (i.e., hypochondriasis) are scarce. Methods In the present study, we investigated the course of (health) anxiety related to SARS-CoV-2/COVID-19 in comparison to (health) anxiety related to other severe diseases (e.g., cancer) in a sample of 12 patients with the diagnosis of pathological health anxiety during the “first wave” of the COVID-19 pandemic in Germany. Both SARS-CoV-2 related anxiety and anxiety related to other severe diseases were assessed weekly…

Signos y síntomas de adicción al cibersexo en adultos mayores

2019

El uso de Internet con objetivos sexuales resulta una práctica cada vez más generalizada en cualquier etapa vital. Si bien en la mayoría de casos el consumo se realiza de forma recreativa, en ocasiones éste puede sobrevenir compulsivo, incontrolado y asociado a un deterioro funcional en diversos ámbitos (adicción al cibersexo). Conocer los síntomas que caracterizan este cuadro clínico constituye una prioridad; sin embargo, disponemos de un pobre conocimiento acerca de su expresión en adultos mayores. Así, este trabajo se planteó con un doble objetivo: 1) analizar la prevalencia de adultos mayores en riesgo de desarrollar o que muestran un perfil patológico de uso del cibersexo y 2) elaborar…

Ethical Gambling: A Necessary New Point of View of Gambling in Public Health Policies

2017

Golgi Fragmentation in Neurodegenerative Diseases: Is There a Common Cause?

2019

In most mammalian cells, the Golgi complex forms a continuous ribbon. In neurodegenerative diseases, the Golgi ribbon of a specific group of neurons is typically broken into isolated elements, a very early event which happens before clinical and other pathological symptoms become evident. It is not known whether this phenomenon is caused by mechanisms associated with cell death or if, conversely, it triggers apoptosis. When the phenomenon was studied in diseases such as Parkinson’s and Alzheimer’s or amyotrophic lateral sclerosis, it was attributed to a variety of causes, including the presence of cytoplasmatic protein aggregates, malfunctioning of intracellular traffic and/or alterations i…

Healthy mitochondria for stroke cells.

2018

Stroke is a debilitating disease that remains as a significant unmet need. Although our understanding of the disease pathology has advanced over the years, treatment options for stroke are limited. Recent studies have implicated the important role of healthy mitochondria in neuroprotection against stroke. Under the stroke pathological condition, transfer of healthy mitochondria is observed from astrocytes to ischemic neurons. However, without additional therapeutic intervention, such astrocyte-to-neuron transfer of mitochondria may not sufficiently afford a robust and stable therapeutic effect against the devastating primary insult and progressive neurodegeneration associated with stroke. W…

Serratia marcescens infection or hypoxic-ischaemic encephalopathy in neonates: Is magnetic resonance imaging a problem-solving tool?

2017

To the Editor: We read with great interest the retrospective case series by A Madide and J Smith,[1] describing brain ultrasound (US) findings of neonates with Serratia marcescens hospital-acquired infections. S. marcescens is a Gram-negative organism that frequently colonises neonatal intensive care units (NICUs). This bacterium can cause severe brain infections in neonates, with irreversible neurological damage and long-term neurodevelopmental impairment. The authors conclude that in babies with acute onset of the illness, US scans allow doctors to highlight pathological changes in the brain immediately before the microbiological diagnosis of infection, and to follow the evolution of thos…

A virtual reality system for the treatment of stress-related disorders: A preliminary analysis of efficacy compared to a standard cognitive behaviora…

2011

This paper presents preliminary efficacy data in a controlled study of the use of a virtual reality (VR) system for treating stress-related disorders (Post-Traumatic Stress Disorder, or PTSD; Pathological Grief, or PG; and Adjustment Disorders, or AD). ''EMMA's World'' is a VR application in which patients can explore negative experiences to the degree required for their specific therapeutic needs. To accomplish therapeutic goals, a series of virtual elements is customized to be meaningful to the user; the elements contain the fundamental emotional components that the person must confront. Thirty-nine participants diagnosed with PTSD (N=10), PG (N=16), and AD (N=13) were randomly assigned t…