Search results for "Peg"
showing 10 items of 460 documents
Methods of protein surface PEGylation under structure preservation for the emulsion-based formation of stable nanoparticles
2016
Proteins show remarkable versatility as multifunctional materials for therapeutic applications. They can be easily modified with the toolkit of bioorganic chemistry and are particularly attractive because of their degradability and biocompatibility. Herein, we evaluate different methods for the attachment of multiple PEG chains on the surface of the enzyme lysozyme. For this, we activated standard 2 kDa mPEG chains with four different electrophilic groups and tested their ability to react with different amino acids on the surface of our model protein. The aim was to find an effective and at the same time mild modification method that preserves the native structure and activity of the enzyme…
Rhabdomyolysis associated with the co-administration of daptomycin and pegylated interferon -2b and ribavirin in a patient with hepatitis C
2011
Visceral leishmaniasis during pegylated interferon therapy for chronic hepatitis C: first report.
2005
See: Puoti et al. Use of pegylated interferons is associated with an increased incidence of infections during combination treatment of chronic hepatitis C: a side effect of pegylation? Antiviral Therapy 2004; 9:627–630.
Identificación de oportunidades de mejora del tratamiento de la hepatitis C
2006
® . Summary Objective: Hepatitis C represents a public health concern with more than 170 million carriers. The goal of this study was to identify improvement opportunities in the management of hepati- tis C, and the pharmaceutical actions performed for the preven- tion and solution of medication-related problems in patients seen at the Pharmaceutical Care Outpatient Unit.
Protein crystallization: universal thermodynamic vs. specific effects of PEG
2008
The interest of nucleation of protein crystals and aggregates (including oligomerization) spans from basic physics theory all the way to biophysics, nanophysics, clinical sciences, biotechnologies, food technologies and polymer–solvent interactions. Understanding nucleation within a theoretical framework capable of providing quantitative predictions and control of nucleation rates, or even the very occurrence of crystallization, is a long-sought goal of remarkable relevance to each of the above fields. A large amount of work has been aimed at such goal, but success has been so far rather limited. Work at our laboratory has more recently highlighted a direct link between nucleation rates and…
Fe Kα and Hydrodynamic Loop Model Diagnostics for a Large Flare on II Pegasi
2008
The observation by the Swift X-ray Telescope of the Fe K alpha_1, alpha_2 doublet during a large flare on the RS CVn binary system II Peg represents one of only two firm detections to date of photospheric Fe K alpha from a star other than our Sun. We present models of the Fe K alpha equivalent widths reported in the literature for the II Peg observations and show that they are most probably due to fluorescence following inner shell photoionisation of quasi-neutral Fe by the flare X-rays. Our models constrain the maximum height of flare the to 0.15 R_* assuming solar abundances for the photospheric material, and 0.1 R_* and 0.06 R_* assuming depleted photospheric abundances ([M/H]=-0.2 and […
Syntaxonomic survey of the class Pegano-Salsoletea in Italy
2012
After a general outline on the syntaxonomical framework of the class Pegano harmalae-Salsoletea vermiculatae Br.-Bl. & O. Bolos 1958, the occurrence of this vegetation in the Italian territory is examined. In Italy, this vegetation is mostly found on clayish or marly substrata, particularly if slightly enriched with nitrates and chlorides. With reference to the Rivas-Martı´nez bioclimatic classification, the Italian stands have an infra- to thermo-Mediterranean thermotype (marginally up to the meso- Mediterranean one) with dry or arid ombrotype. In particular, this vegetation is well represented in Sicily, while in Sardinia and along the Italian Peninsula, it progressively becomes more rare…
Image Compression by 2D Motif Basis
2011
Approaches to image compression and indexing based on extensions to 2D of some of the Lempel-Ziv incremental parsing techniques have been proposed in the recent past. In these approaches, an image is decomposed into a number of patches, consisting each of a square or rectangular solid block. This paper proposes image compression techniques based on patches that are not necessarily solid blocks, but are affected instead by a controlled number of undetermined or don't care pixels. Such patches are chosen from a set of candidate motifs that are extracted in turn from the image 2D motif basis, the latter consisting of a compact set of patterns that result from the autocorrelation of the image w…
Collapsibility of metastable sand by non-conventional oedometer tests
2018
The stability of foundations soils could represent a clear and present threat for the conservation of even well preserved buildings, particularly for Architectural heritage conservation and land art heritage. A dramatic case is the presence of collapsible metastable sands as foundation soils, as it occurs in the sacral complex Valle dei Templi in Agrigento. This site listed by UNESCO, stands on a crest of a calcarenite cuesta, overlaying a layer of these sands. When the collapsible sand is dry, the structure is strong enough to bond the sand particles together. When the sand becomes wet, a de-structuration mechanism occurs and the soil’s strength is compromised. This paper has a twofold aim…