Search results for "Pepsinogen"
showing 4 items of 14 documents
Trial profile: pilot study of the multicentre randomised trial of H. pylori eradication and pepsinogen testing for prevention of gastric cancer morta…
2019
Purpose: The GISTAR Pilot study is part of a large multi-centre randomised trial conducted in Latvia with the main aim to evaluate preventive strategies to decrease mortality from gastric cancer in high-risk areas, especially in the Baltic States and Eastern Europe. Participants: A total of 3,447 apparently healthy, asymptomatic participants (40-64 y/o) were recruited between 2013 and 2015 for the GISTAR pilot study. Participants were interviewed for socio-economic status, lifestyle, environmental and occupational exposures, medical history, family history of diseases, and dietary habits. Participants were randomly assigned to either Intervention (n=1,724) or Control (n=1,723) group. The in…
Zinc acexamate inhibits gastric acid and pepsinogen secretion in the rat.
1990
Abstract Pretreatment with zinc acexamate (25–100 mg kg−1 i.p.) inhibited acid and pepsinogen secretion in the pylorus-ligated rat. Zinc acexamate (5–50 mg kg−1 p.o.) also inhibited the increases in acid secretion induced by carbachol (10 μg kg−1) and 2-deoxy-D-glucose (200 mg kg−1) in the perfused stomach of the anaesthetized rat. A delayed antisecretory effect was observed with this drug on histamine induced responses. High concentrations of zinc acexamate (10−5-10−2 M) did not modify the in-vitro activity of pepsin. Administration of zinc acexamate resulted in an increase in the presence of pepsinogen at the mucosal level. A morphological examination of the gastric mucosa confirmed an ac…
Non-Invasive Diagnosis of Gastroesophageal Reflux Disease Using Gastrin- and Pepsinogen-Based Tests
2018
Abstract Gastrin-17 (G-17), pepsinogen-1 (Pg1) and pepsinogen-2 (Pg2) reflect the functional state of gastric mucosa and are used for non-invasive diagnosis and screening of atrophic gastritis. The aim of the study was to clarify if erosive reflux disease (ERD) or non-ERD (NERD) can be distinguished from other dyspeptic conditions in patients, in a non-invasive manner using specific biomarkers. Levels of G-17, Pg1, and Pg2 were measured in 141 ERD patients (median age 48 years, males — 68), 122 NERD patients (median age 45 years, males — 32) and 410 control patients (median age 50 years, males — 97). Levels of biomarkers in ERD and NERD groups were compared to controls. Median levels of G-1…
Pepsinogēna un gastrīna-17 nozīme autoimūna gastrīta diagnostikā
2015
Ievads: AG ir pārāk reti diagnosticēts stāvoklis ar augstu KV attīstības risku. Ilgstošas asimptomātiskas gaitas dēļ to ir grūti diagnosticēt, tāpēc nepieciešamas jaunas, efektīvas un mazāk invazīvas diagnostikas metodes. Mērķis: Darba mērķis ir analizēt seruma biomarķieru (pepsinogēns, G-17) nozīmīgumu AG diagnostikā. Materiāli un metodes: Pētījuma modelis ir nejaušās izlases princips, iekļaujot pacientus, kuri laika periodā no 2004. - 2014. gadam Gremošanas veikuši augšējā gastrointenstinālā trakta endoskopiju. Lai izmērītu seruma biomarķieru (pepsinogēns un G-17) līmeni, pacientiem tika ņemti asins paraugi. Balstoties uz Sidnejas klasifikāciju, tika ņemtas biopsijas. Rezultāti: Pētījumā …