Search results for "Personalized"
showing 10 items of 165 documents
Is Structured Exercise Performed with Supplemental Oxygen a Promising Method of Personalized Medicine in the Therapy of Chronic Diseases?
2020
Aim: This systematic review aimed to explore the literature to identify in which types of chronic diseases exercise with supplemental oxygen has previously been utilized and whether this type of personalized therapy leads to superior effects in physical fitness and well-being. Methods: Databases (PubMed/MEDLINE, CINHAL, EMBASE, Web of knowledge and Cochrane Library) were searched in accordance with PRISMA. Eligibility criteria included adult patients diagnosed with any type of chronic diseases engaging in supervised exercise training with supplemental oxygen compared to normoxia. A random-effects model was used to pool effect sizes by standardized mean differences (SMD). Results: Out of the…
Treatment of clinically localized renal tumors in the elderly
2011
There are several options for treating clinically localized renal tumors in the elderly, ranging from active surveillance to radical nephrectomy. Reduced renal function is associated with increased cardiovascular mortality, so maintaining renal function is of the utmost importance. Personalized therapy should be based on tumor location, comorbidities and general health status rather than tumor size and patient age.
Clinical Development of Mepolizumab for the Treatment of Severe Eosinophilic Asthma: On the Path to Personalized Medicine.
2021
The development of mepolizumab, an anti-IL-5 monoclonal antibody for the treatment of severe eosinophilic asthma, is an example of a clinical development program that evolved over time based on sound, basic scientific principles. Initial clinical data on the effects of mepolizumab on lung function in a general asthmatic population were disappointing. However, it became clear that mepolizumab may be more effective against other clinical endpoints, particularly asthma exacerbations, in patients with more severe disease. Furthermore, a developing understanding of asthma disease pathobiology led to the identification of an appropriate target population and predictive biomarker for mepolizumab t…
Immunologic microenvironment and personalized treatment in multiple myeloma.
2013
Introduction: Multiple myeloma (MM) is characterized by generalized immune suppression and increased susceptibility to infections and secondary malignancies. Malignant plasma cells (PCs) modulate the bone marrow microenvironment to favor their own survival and proliferation. These events lead to a severe deregulation of immune effectors. Extensive studies have been conducted to unveil the mechanisms through which MM cells negatively modulate immunity and to develop therapeutical approaches for restoring an efficient anti-MM immune response. Areas covered: This review article covers both the immunosuppressive effects exerted by MM and the immunomodulatory potential of novel anti-MM agents. A…
Progettare interventi didattici personalizzati: implicazioni per la formazione dei futuri insegnanti
2020
L’articolo riporta i risultati di un’indagine sul terzo anno di tirocinio nel corso di laurea magistrale (LM 85-bis) in Scienze della Formazione Primaria dell’Università degli Studi di Palermo nell’anno accademico 2019-2020. È stato chiesto ai 269 studenti, che avevano svolto nei mesi precedenti 50 ore di tirocinio in classe, di descrivere le loro progettazion didattiche seguendo una guida, appositamente costruita, che li aiutasse anche a svolgere una riflessione metacognitiva sulla didattica personalizzata; inoltre la capacità decisionale degli studenti, valutata con il test QTD, è stata messa in relazione con la loro capacità di progettare in una scuola inclusiva. Al fine di preparare il …
The analysis of teaching practices at school and at university.
2011
It is well-known that teachers are required to have an experimental mentality leading them to constantly verify the educational efficiency of their teaching actions and make new hypotheses to improve. Actually, what really happens at school is that intuition is predominant because of the lack of time, so these hypotheses are quite dim, working procedures are the fruit of almost indefinite improvisation, and assessment does not fit the need for observing the benefits and results of learning or it is not even carried out at all. Therefore, it is required for school teachers to have a strong methodological competence in the field of teaching research. The Research Group at the University of Pa…
Is HLA type a possible cancer risk modifier in Lynch syndrome?
2022
Lynch syndrome (LS) is the most common inherited cancer syndrome. It is inherited via a monoallelic germline variant in one of the DNA mismatch repair (MMR) genes. LS carriers have a broad 30-80% risk of developing various malignancies, and more precise, individual risk estimations would be of high clinical value, allowing tailored cancer prevention and surveillance. Due to MMR deficiency, LS cancers are characterized by the accumulation of frameshift mutations leading to highly immunogenic frameshift peptides (FSPs). Thus, immune surveillance is proposed to inhibit the outgrowth of MMR-deficient cell clones. Recent studies have shown that immunoediting during the evolution of MMR-deficient…
Best practices for teaching boys
2015
Boys are the ones in trouble, they say. They are trailing girls in reading and writing, are more likely to get in trouble or be labelled as learning disabled, and are less likely to go to college. Educators, citing emerging brain research, say that the two sexes learn differently and that schools are more geared to girls than to their ants-in-the-pants counterparts. But they are adopting strategies to help boys succeed, from playing multiplication baseball to handing out stress balls and setting up boys-only schools. Nowadays, there is an urgent call for a more significant presence of male teachers in primary schools. Here are the results of an extensive research concerning gender differenc…
Inverse estimation of the cardiac purkinje system from electroanatomical maps
2020
Las enfermedades cardiovasculares son la primera causa de mortalidad en el mundo, con 17.7 millones de muertes cada año, aproximadamente el 31% de las muertes en todo el mundo (Organización Mundial de la Salud (OMS) 2018). Las arritmias ventriculares son una causa importante de muerte súbita, que representa aproximadamente la mitad de la mortalidad cardíaca. Algunas de esas arritmias se atribuyen a la red de Purkinje (PKN), que bajo ciertas condiciones puede generar ritmos focales automáticos, y su configuración de red puede sostener circuitos eléctricos reentrantes. Los ritmos focales originados desde la red de Purkinje pueden servir como puntos de inicio en casos de fibrilación ventricula…