Search results for "Phenibut"

showing 2 items of 2 documents

Fenibuta piemaisījumu kvantitatīvas noteikšanas metodes optimizācija un validācija

2021

Kokina. P., zinātniskie vadītāji: Dr. ķīm. V. Bartkevičs (LU), Dr. ķīm. A. Bolotin (AS Olainfarm). Maģistra darbs, 147 lappuses, 184 attēli, 75 tabulas, 15 literatūras avoti, 16 pielikumi. Latviešu valodā. Maģistra darbā ir veikta divu piemaisījumu(4-amino-3-fenilbutānskābes etilestera hidrohlorīds un 4-fenil-2-pirrolidons) kvantitatīvas noteikšanas analīzes metodes optimizācija un validācija farmaceitiskā preperāta Noofen® aktīvajai farmaceitiskai vielai (AFV) fenibuts. Metodes optimizācija un validācija bija nepieciešama farmaceitiskā preparāta Noofen® kvalitātes kontroles vajadzībām. Fenibuta paraugi tika analizēti ar augsti efektīvo šķidruma hromatogrāfiju (AEŠH). Optimizācija tika vērs…

FENIBUTS PHENIBUTPIEMAISĪJUMU NOTEIKŠANAS OPTIMIZĀCIJA OPTIMIZATION OF IMPURITY DETERMINATION METHODAUGSTI EFEKTĪVĀ ŠĶIDRUMA HROMATOGRĀFIJA HIGH PERFORMANCE LIQUID CHROMATOGRAPHY4-FENIL-2-PIRROLIDONS 4-PHENYL-2- PYRROLIDONEĶīmija4-AMINO3-FENILBUTĀNSKĀBES ETILESTERA HIDROHLORĪDS 4-AMINO3-PHENYLBUTANOIC ACID ETHYL ESTER HYDROCHLORIDE
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Comparative pharmacological activity of optical isomers of phenibut

2007

Phenibut (3-phenyl-4-aminobutyric acid) is a GABA (gamma-aminobutyric acid)-mimetic psychotropic drug which is clinically used in its racemic form. The aim of the present study was to compare the effects of racemic phenibut and its optical isomers in pharmacological tests and GABAB receptor binding studies. In pharmacological tests of locomotor activity, antidepressant and pain effects, S-phenibut was inactive in doses up to 500 mg/kg. In contrast, R-phenibut turned out to be two times more potent than racemic phenibut in most of the tests. In the forced swimming test, at a dose of 100 mg/kg only R-phenibut significantly decreased immobility time. Both R-phenibut and racemic phenibut showed…

MaleHot TemperaturePhenibutMotor ActivityPharmacologyGABAB receptorConflict PsychologicalGABA AntagonistsMicechemistry.chemical_compoundOrganophosphorus CompoundsReaction TimemedicineAnimalsMuscle StrengthGABA AgonistsPostural BalanceSwimminggamma-Aminobutyric AcidPain MeasurementPharmacologyAnalgesicsMice Inbred ICRPsychotropic DrugsDepressionAntagonistStereoisomerismBiological activityAntidepressive AgentsPsychotropic drugBaclofenReceptors GABA-BchemistryMice Inbred CBAEnantiomerPsychomotor Performancemedicine.drugBehavioural despair testEuropean Journal of Pharmacology
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