Search results for "Pie"
showing 10 items of 4404 documents
How consistent are the transcriptome changes associated with cold acclimation in two species of the Drosophila virilis group?
2015
This work was financially support by a Marie Curie Initial Training Network grant, “Understanding the evolutionary origin of biological diversity” (ITN-2008–213780 SPECIATION), grants from the Academy of Finland to A.H. (project 132619) and M.K. (projects 268214 and 272927), a grant from NERC, UK to M.G.R. (grant NE/J020818/1), and NERC, UK PhD studentship to D.J.P. (NE/I528634/1). For many organisms the ability to cold acclimate with the onset of seasonal cold has major implications for their fitness. In insects, where this ability is widespread, the physiological changes associated with increased cold tolerance have been well studied. Despite this, little work has been done to trace chang…
Orientālistika: Cilvēkzināšana un Āzijas aktualitātes (Latvijas Universitātes Raksti, 819. sējums)
2021
Spray Freeze Dried Lyospheres® for Nasal Administration of Insulin
2021
Pharmacologically active macromolecules, such as peptides, are still a major challenge in terms of designing a delivery system for their transport across absorption barriers and at the same time provide sufficiently high long-term stability. Spray freeze dried (SFD) lyospheres® are proposed here as an alternative for the preparation of fast dissolving porous particles for nasal administration of insulin. Insulin solutions containing mannitol and polyvinylpyrrolidone complemented with permeation enhancing excipients (sodium taurocholate or cyclodextrins) were sprayed into a cooled spray tower, followed by vacuum freeze drying. Final porous particles were highly spherical and mean diameters r…
Novel insights into excipient effects on the biopharmaceutics of APIs from different BCS classes: Lactose in solid oral dosage forms
2014
Excipients encompass a wide range of properties that are of importance for the resulting drug product. Regulatory guidelines on biowaivers for immediate release formulations require an in depth understanding of the biopharmaceutic effects of excipients in order to establish bioequivalence between two different products carrying the same API based on dissolution tests alone. This paper describes a new approach in evaluating biopharmaceutic excipient effects. Actually used quantities of a model excipient, lactose, formulated in combination with APIs from different BCS classes were evaluated. The results suggest that companies use different (relative) amounts depending on the characteristics o…
Inherited semisterility for control of harmful insects. I. Productions of semisterility due to translocation in the mosquito,Culex pipiens L., by X-r…
1971
In Anbetracht der theoretischen und in einem Freilandexperiment bereits erwiesenen Moglichkeit der Bekampfung von Schadinsekten durch Freilassung semisteriler Tiere wurde die Produktion von Translokationen und damit verbundener Semisterilitat bei der StechmuckeCulex pipiens untersucht. Die Totalrate der erzeugten Translokationen liegt bei Stechmucken im Vergleich zuDrosophila auffallend hoch. Es besteht offenbar eine Korrelation zwischen der Gesamtlange der Chromosomen und der Translokationsrate.
Estudio sobre la cicatrización de la zona donante de injerto de piel parcial en pacientes quemados tras aplicación de plasma rico en plaquetas o plas…
2019
La técnica más empleada para la restauración de la barrera cutánea en los pacientes quemados es el injerto de piel autólogo de espesor parcial. Su obtención conlleva generar un área cruenta a nivel de otra localización cutánea del mismo paciente, conocida como zona donante. Esta área cura generalmente en un período de entre 7 y 14 días mediante un proceso de cicatrización dirigida. Cuando existen grandes defectos que requieren cobertura, como es el caso de los grandes quemados en los que la extensión de la quemadura limita la disponibilidad de área donante, pueden ser necesarias varias tomas de la misma zona. Por lo tanto, la opción terapéutica global en este tipo de pacientes va a depender…
Antennas for the detection of radio emission pulses from cosmic-ray induced air showers at the Pierre Auger Observatory.
2012
The Pierre Auger Observatory is exploring the potential of the radio detection technique to study extensive air showers induced by ultra-high energy cosmic rays. The Auger Engineering Radio Array (AERA) addresses both technological and scientific aspects of the radio technique. A first phase of AERA has been operating since September 2010 with detector stations observing radio signals at frequencies between 30 and 80 MHz. In this paper we present comparative studies to identify and optimize the antenna design for the final configuration of AERA consisting of 160 individual radio detector stations. The transient nature of the air shower signal requires a detailed description of the antenna s…
Measurement of the radiation energy in the radio signal of extensive air showers as a universal estimator of cosmic-ray energy
2016
We measure the energy emitted by extensive air showers in the form of radio emission in the frequency range from 30 to 80 MHz. Exploiting the accurate energy scale of the Pierre Auger Observatory, we obtain a radiation energy of 15.8±0.7(stat)±6.7(syst) MeV for cosmic rays with an energy of 1 EeV arriving perpendicularly to a geomagnetic field of 0.24 G, scaling quadratically with the cosmic-ray energy. A comparison with predictions from state-of-the-art first-principles calculations shows agreement with our measurement. The radiation energy provides direct access to the calorimetric energy in the electromagnetic cascade of extensive air showers. Comparison with our result thus allows the d…
Searches for Large-Scale Anisotropy in the Arrival Directions of Cosmic Rays Detected above Energy of $10^{19}$ eV at the Pierre Auger Observatory an…
2014
Spherical harmonic moments are well-suited for capturing anisotropy at any scale in the flux of cosmic rays. An unambiguous measurement of the full set of spherical harmonic coefficients requires full-sky coverage. This can be achieved by combining data from observatories located in both the northern and southern hemispheres. To this end, a joint analysis using data recorded at the Telescope Array and the Pierre Auger Observatory above 1019 eV is presented in this work. The resulting multipolar expansion of the flux of cosmic rays allows us to perform a series of anisotropy searches, and in particular to report on the angular power spectrum of cosmic rays above 1019 eV. No significant devia…
Cavanilles y las mordeduras de víbora
1996
El presente trabajo pretende recordar, en una visión retrospectiva, el tratamiento de las mordeduras de víbora según los escritos de A. J. Cavanilles, de gran vigencia entre 1793 y 1802. Se citan los polvos vegetales integrantes de la mezcla utilizada para el tratamiento, la recolección de los mismos y la dosis a administrar del preparado al uso de la época, especialmente, en tierras de Els Ports y de La Foia de Castalla.