Search results for "Pike"
showing 10 items of 130 documents
Hippocampal Sharp Waves: A Physiological Correlate of LTP?
1988
The irregularly occurring large amplitude hippocampal sharp waves (SPWs) are correlated with synchronous population bursts of CA1-CA3 and subicular pyramidal cells, dentate granule cells and interneurons in all hippocampal fields. We suggest that the SPW-associated neuronal burst is the best candidate for a physiological basis of long-term potentiation (LTP).
Indice de réflexion latérale du saumon Atlantique (Salmo salar), de la truite de mer (Salmo trutta), du corégone (Coregonus lavaretus) et du brochet …
2000
L'indice de reflexion acoustique laterale (TS) de 19 saumons Atlantique (Salmo salar), 16 truites de mer (Salmo trutta), 10 coregones (Coregonus lavaretus) et 7 brochets (Esox lucius) a ete mesure en utilisant un sondeur de 200 kHz, afin d'etudier la relation entre l'indice TS et la taille, le poids et la surface du poisson. Les effets de l'angle d'incidence sur l'indice TS ont aussi ete etudies. Des modeles lineaires entre TS et le logarithme de l'indice de taille du poisson ont ete ajustes et ont montre que la meilleure prevision provient de l'indice de longueur. Classiquement, l'erreur standard de l'estimation etait de 1,2 a 2,9 dB. Les resultats des mesures de TS sur des poissons de lon…
Pikettyn jälkipuintia
2017
Special Features of the Hippocampal Formation with Respect to Seizure Conditions
1987
The hippocampus has long been known as a region particularly prone to epileptiform discharges (Kandel et al. 1961). Connections and physiology of this archaic cortical structure are relatively well charac-terized and a wealth of information on features favoring exaggerated neuronal activity has emerged in recent years. The lamellar organization of the hippo-campus (Andersen et al. 1971) may be one of these features; it certainly has facilitated their investigation. Tissue slices cut along the lamellae, perpendicular to the axis of the structure, contain a relatively undisturbed chain of neurons which can be rigorously investigated in vitro. The results from such experiments have allowed mod…
Macrolides May Prevent Severe Acute Respiratory Syndrome Coronavirus 2 Entry into Cells: A Quantitative Structure Activity Relationship Study and Exp…
2021
The global pandemic caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is threatening the health and economic systems worldwide. Despite the enormous efforts of scientists and clinicians around the world, there is still no drug or vaccine available worldwide for the treatment and prevention of the infection. A rapid strategy for the identification of new treatments is based on repurposing existing clinically approved drugs that show antiviral activity against SARS-CoV-2 infection. In this study, after developing a quantitative structure activity relationship analysis based on molecular topology, several macrolide antibiotics are identified as promising SARS-…
Changes in neural drive to calf muscles during steady submaximal contractions after repeated static stretches
2021
Key points: Repeated static-stretching interventions consistently increase the range of motion about a joint and decrease total joint stiffness, but findings on the changes in muscle and connective-tissue properties are mixed. The influence of these stretch-induced changes on muscle function at submaximal forces is unknown. To address this gap in knowledge, the changes in neural drive to the plantar flexor muscles after a static-stretch intervention were estimated. Neural drive to the plantar flexor muscles during a low-force contraction increased after repeated static stretches. These findings suggest that adjustments in motor unit activity are necessary at low forces to accommodate reduct…
Structure‐ and Interaction‐Based Design of Anti‐SARS‐CoV‐2 Aptamers
2022
Aptamer selection against novel infections is a complicated and time-consuming approach. Synergy can be achieved by using computational methods together with experimental procedures. This study aims to develop a reliable methodology for a rational aptamer in silico et vitro design. The new approach combines multiple steps: (1) Molecular design, based on screening in a DNA aptamer library and directed mutagenesis to fit the protein tertiary structure; (2) 3D molecular modeling of the target; (3) Molecular docking of an aptamer with the protein; (4) Molecular dynamics (MD) simulations of the complexes; (5) Quantum-mechanical (QM) evaluation of the interactions between aptamer and target with …
UV-B exposure causes DNA damage and changes in protein expression in northern pike (Esox lucius) posthatched embryos.
2012
The ongoing anthropogenically caused ozone depletion and climate change has increased the amount of biologically harmful UV-B radiation, which is detrimental to fish in embryonal stages. The effects of UV-B radiation on the levels and locations of DNA damage manifested as cyclobutane pyrimidine dimers (CPDs), heat shock protein 70 (HSP70) and p53 protein in newly hatched embryos of pike were examined. Pike larvae were exposed in the laboratory to current and enhanced doses of UV-B radiation. UV-B exposure caused the formation of CPDs in a fluence rate-dependent manner, and the CPDs were found deeper in the tissues with increasing fluence rates. UV-B radiation induced HSP70 in epidermis, and…
Burst analysis tool for developing neuronal networks exhibiting highly varying action potential dynamics
2012
In this paper we propose a firing statistics based neuronal network burst detection algorithm for neuronal networks exhibiting highly variable action potential dynamics. Electrical activity of neuronal networks is generally analyzed by the occurrences of spikes and bursts both in time and space. Commonly accepted analysis tools employ burst detection algorithms based on predefined criteria. However, maturing neuronal networks, such as those originating from human embryonic stem cells (hESCs), exhibit highly variable network structure and time-varying dynamics. To explore the developing burst/spike activities of such networks, we propose a burst detection algorithm which utilizes the firing …