Search results for "Pill"
showing 10 items of 1870 documents
Human Papillomavirus Type 16 E7 Peptide-Directed CD8+ T Cells from Patients with Cervical Cancer Are Cross-Reactive with the Coronavirus NS2 Protein
2003
ABSTRACTHuman papillomavirus type 16 (HPV16) E6 and E7 oncoproteins are required for cellular transformation and represent candidate targets for HPV-specific and major histocompatibility complex class I-restricted CD8+-T-cell responses in patients with cervical cancer. Recent evidence suggests that cross-reactivity represents the inherent nature of the T-cell repertoire. We identified HLA-A2 binding HPV16 E7 variant peptides from human, bacterial, or viral origin which are able to drive CD8+-T-cell responses directed against wild-type HPV16 E7 amino acid 11 to 19/20 (E711-19/20) epitope YMLDLQPET(T) in vitro. CD8+T cells reacting to the HLA-A2-presented peptide from HPV16 E711-19(20)recogni…
Evaluation of HBs, HBc, and frCP virus-like particles for expression of human papillomavirus 16 E7 oncoprotein epitopes.
2002
<i>Objectives:</i> In an attempt to develop virus-like particles (VLPs) as experimental vaccine against human papilloma virus (HPV)-induced tumours, the HPV16 E7 oncoprotein epitopes spanning amino acid (aa) residues 35–98 were expressed on three proteins capable of VLP formation: hepatitis B virus (HBV) surface (HBs) and core (HBc) antigens, and RNA phage fr coats (frCP). <i>Methods:</i> The profile of immunoglobulin isotypes induced in Balb/C mice after immunization with purified chimeric proteins was studied. <i>Results:</i> The HBs*-E7(35–54) protein expressing E7 residues 35–54 between residues 139 and 142 of the HBs carrier formed HBs-like particles…
A short introduction to papillomavirus biology.
2003
In this report, the tropism of papillomaviruses, the structure of virions, the function of viral proteins and the use of pseudovirions for the analysis of the immune response against papillomaviruses and the search for the viral receptor are briefly described.
Clathrin- and Caveolin-Independent Entry of Human Papillomavirus Type 16—Involvement of Tetraspanin-Enriched Microdomains (TEMs)
2008
BACKGROUND: Infectious entry of human papillomaviruses into their host cells is an important step in the viral life cycle. For cell binding these viruses use proteoglycans as initial attachment sites. Subsequent transfer to a secondary receptor molecule seems to be involved in virus uptake. Depending on the papillomavirus subtype, it has been reported that entry occurs by clathrin- or caveolin-mediated mechanisms. Regarding human papillomavirus type 16 (HPV16), the primary etiologic agent for development of cervical cancer, clathrin-mediated endocytosis was described as infectious entry pathway. METHODOLOGY/PRINCIPAL FINDINGS: Using immunofluorescence and infection studies we show in contra…
Vanhempien työ, työn siirräntä kotiin ja lasten hyvinvointi : kohtaamisia tuulikaapissa
2013
Vairogdziedzera papillāro vēžu sastopamība "P.Stradiņa KUS" un klīnisko gadījumu analīze no 2010.-2015. gadam
2016
Pēc onkoloģijas reģistra datiem, pierādījām, ka Latvijā ir papillāra vēža incidences pieaugums un analizējām kā tas ietekmē operācijas apjomu P. Stradiņa KUS atlasītajiem 250 pacientiem no 2010.–2015. gadam. Mēs noteicām faktorus, kas varētu ietekmēt operācijas apjomu. Statistiski ticami operācijas apjomu ietekmē audzēja izmērs (p=0.031) un FNA papillāram un mikropapillāram vēzim, bet tikai gadījumos, kad veikta totāla tiroīdekotmija (p=0.02). Pierādījām, ka 50% audzēja izmērs ir 1.1–4 cm un totāla tiroīdektomija dominē visās audzēja izmēra grupās. Mikropapillāram vēzim totāla tiroīdektomija visbiežāk tika veikta šūnu atipijas dēļ, bet papillāram - malignas citoloģijas atbildes dēļ. Vecums …
First report on the helminthfauna of the yellow-necked mouse, Apodemus flavicollis, in the Iberian Peninsula
2016
Summary Information about the prevalence of helminth parasites of the yellow-necked mouse, Apodemus flavicollis, in the Iberian Peninsula is almost non-existent and there is no reliable data reported from Spain. Fourteen A. flavicollis from the Erro River valley (Navarre, Spain) were examined for endoparasites, between February 2001 and July 2002. Thirteen specimens (92.9 %) of the total sample were parasitized by at least one of the following six helminth species: one trematode (Corrigia vitta), one cestode (Taenia parva larvae) and four nematodes (Trichuris muris, Calodium hepaticum, Heligmosomoides polygyrus and Syphacia stroma). This is the first report about the helminthfauna of A. fla…
Bladder tumours in children: An interesting case report of TCC with a partial inverted growth pattern.
2014
Bladder urothelial carcinoma is typically a disease of older individuals and rarely occurs below the age of 40 years. There is debate and uncertainty in the literature regarding the clinicopathologic and prognostic characteristics of bladder urothelial neoplasms in younger patients compared with older patients, although no consistent age criteria have been used to define "younger" age group categories. We report on a 16 years old girl with transitional cell carcinoma of the bladder with a partial inverted growth pattern who presented with gross hematuria. Ultrasonography revealed a papillary lesion in the bladder; cystoscopic evaluation showed a 15 mm papillary lesion with a thick stalk loc…
Kognitīvas slodzes ietekme uz gaismas stimula izraisītu zīlīšu refleksu
2015
Maģistra darbs ir uzrakstīts latviešu valodā, datorsalikumā uz 45 lappusēm. Darbs satur 26 attēlus, 7 tabulām un 45 atsaucēm uz izmantoto literatūru. Šajā darbā “Kognitīvas slodzes ietekme uz gaismas stimula izraisītu zīlīšu refleksu” autore apskata dažādu intensitāšu kognitīvo slodžu ietekmi uz zila un balta, konstanta vai sinusoidāla stimula izraisītu zīlīšu refleksu. Tika secināts, ka, palielinoties kognitīvas slodzes intensitātei, zīlītes diametrs sašaurinās. Kognitīvā slodze rada ietekmi uz zīlīšu refleksa parametriem – izmeklēto personu grupas vidējie rādītāji neuzrāda viennozīmīgu ietekmi. Daļai indivīdu bija novērotas izmaiņas latentā perioda, amplitūdas un laika konstantes t50% vēr…
Contribution to the modeling of microstructural corrosion on aluminium alloys : definition of a methodology to study the bimetallic corrosion phenome…
2008
The initiation and the propagation of aluminum alloys microstructural corrosion is mainly based on the bimetallic corrosion phenomenon. This type of corrosion is caused by galvanic coupling at a local scale between the different phases contained in the alloy. The description of the localized corrosion phenomenon has been largely studied. Their complexity can explain why they are so difficult to predict by the way of numerical tools and why the works that have been done on this subject are so scarce. The present thesis brings a new contribution to this field by suggesting a methodology based on the complementary use of local electrochemical techniques and the finite element simulation of bim…