Search results for "Pill"
showing 10 items of 1870 documents
Crosstalk of the plasma contact system with bacteria.
2012
Activation of the plasma contact system triggers several cascade systems such as the kallikrein-kinin system, the intrinsic pathway of coagulation, the classical complement cascade and the fibrinolytic system. Recent studies have shown a critical role of the contact system for arterial and venous thrombus formation and thromboembolic disease. In contrast, the function of the contact system for host-defense reactions and its physiological functions have remained enigmatic. Experimental animal studies and clinical data have linked the contact system to bacterial infections with implications for sepsis disease. The present review summarizes the role of the contact system and its activation for…
2018
Oncogenic human papillomaviruses (HPV) are small DNA viruses that infect keratinocytes. After HPV binding to cell surface receptors, a cascade of molecular interactions mediates the infectious cellular internalization of virus particles. Aside from the virus itself, important molecular players involved in virus entry include the tetraspanin CD151 and the epidermal growth factor receptor (EGFR). To date, it is unknown how these components are coordinated in space and time. Here, we studied plasma membrane dynamics of CD151 and EGFR and the HPV16 capsid during the early phase of infection. We find that the proteinase ADAM17 activates the extracellular signal-regulated kinases (ERK1/2) pathway…
Unsaturated Fatty Acids Drive Disintegrin and Metalloproteinase (ADAM)-dependent Cell Adhesion, Proliferation, and Migration by Modulating Membrane F…
2011
The disintegrin-metalloproteinases ADAM10 and ADAM17 mediate the release of several cell signaling molecules and cell adhesion molecules such as vascular endothelial cadherin or L-selectin affecting endothelial permeability and leukocyte transmigration. Dysregulation of ADAM activity may contribute to the pathogenesis of vascular diseases, but the mechanisms underlying the control of ADAM functions are still incompletely understood. Atherosclerosis is characterized by lipid plaque formation and local accumulation of unsaturated free fatty acids (FFA). Here, we show that unsaturated FFA increase ADAM-mediated substrate cleavage. We demonstrate that these alterations are not due to genuine ch…
p53 mutations are common in human papillomavirus type 38-positive non-melanoma skin cancers
2004
Copyright © 2003 Elsevier Ireland Ltd. All rights reserved.
Comparison between sodium dodecylsulphate and cetyltrimethylammonium bromide as mobile phases in the micellar liquid chromatography determination of …
2004
The retention behaviour of non-steroidal anti-inflammatory drugs (NSAIDs) using micellar mobile phases of sodium dodecylsulphate (SDS) is studied and compared with that observed with micellar mobile phases of cetyltrimethylammonium bromide (CTAB). A liquid chromatographic procedure for the determination of acemetacin, diclofenac, indomethacin, ketoprofen, naproxen and tolmetin in pharmaceutical preparations is described. The proposed system uses a Kromasil C18 analytical column and a solution of 0.15 M SDS at pH 3 with 10% 1-propanol as mobile phase. Under these conditions, the studied NSAIDs elute between 6 and 10 min at a 1 mL min(-1) flow rate. Limits of detection (LOD) are lower than 0.…
Monitahoisten vaatimusten keskellä: Yksinhuoltajaäitien epätyypilliset työajat ja työn ja perhe-elämän yhteensovittaminen
2020
Useat Suomen mediassa viime vuosina julkaistut otsikot yhdessä kansainvälisten työn ja perhe-elämän yhteensovittamista tarkastelleiden tutkimusten kanssa ovat osoittaneet, että yksinhuoltajaäitien työ epätyypillisinä aikoina, esimerkiksi iltaisin, öisin ja viikonloppuisin, voi vahvistaa perheiden arjessaan kohtaamia haasteita. Äitien vuorotyö sekä työn ja perhe-elämän yhteensovittamisen haasteet voivat heijastua kielteisesti myös lapsen hyvinvointiin. Vaikka Suomessa naisten epätyypilliset työajat ovat yleisiä, tutkimustietoa yksinhuoltajaäitien kokemuksista ei ole juuri ollut saatavilla. Väitöskirjatutkimukseni kysyikin, kuinka yksinhuoltajaäidit Suomessa, Alankomaissa ja Isossa-Britannias…
Entrepreneurial ecosystems, knowledge spillovers, and their embeddedness in the sport field: a bibliometric and content analysis
2020
The aim of this article is to review the emerging research on entrepreneurial ecosystems and knowledge spillovers in general, and in the sport field in particular through bibliometric and content a...
The knowledge spillover effect of crowdfunding
2020
Knowledge exerts a positive indirect effect on the external environment. However, not all innovations are transferred to companies and society to allow such an effect to occur. Given the existence ...
The vaccina
2018
Objective The aim of this study was to introduce the VaccinaTion & Hpv Knowledge (THinK) questionnaire to assess knowledge about human papillomavirus (HPV) and attitude to HPV-vaccination. Its reliability and validity was demonstrated in a sample of women living in Sicily (southern Italy). Methods A cross-sectional survey was conducted on a sample of 220 women at the “Paolo Giaccone” University Hospital in Palermo (Sicily), aged 18–61. Data were analyzed through Cronbach’s alpha and exploratory factor analysis, followed by a structural equation model with measurement component. The two-level data structure was explicitly considered. Results Three dimensions were found: “knowledge of HPV inf…
Organization of the major and minor capsid proteins in human papillomavirus type 33 virus-like particles.
1995
The organization of the major (L1) and minor (L2) proteins in the human papillomavirus capsid is still largely unknown. In this study we analysed the disulphide bonding between L1 proteins and the association of L2 proteins with capsomers using virus-like particles obtained in insect cells by co-expression of the L1 and L2 genes of human papillomavirus type 33. About 50% of the L1 protein molecules in these particles (1.29 g/cm3) formed disulphide-bonded trimers. Reduction of the intermolecular disulphide bonds by dithiothreitol (DTT) treatment caused disassembly of virus-like particles into capsomers. This indicates that disulphide bonds between capsomers at the threefold symmetry position…