Search results for "Pines"
showing 10 items of 421 documents
Amyloid Beta-Mediated Changes in Synaptic Function and Spine Number of Neocortical Neurons Depend on NMDA Receptors
2021
Onset and progression of Alzheimer’s disease (AD) pathophysiology differs between brain regions. The neocortex, for example, is a brain region that is affected very early during AD. NMDA receptors (NMDARs) are involved in mediating amyloid beta (Aβ) toxicity. NMDAR expression, on the other hand, can be affected by Aβ. We tested whether the high vulnerability of neocortical neurons for Aβ-toxicity may result from specific NMDAR expression profiles or from a particular regulation of NMDAR expression by Aβ. Electrophysiological analyses suggested that pyramidal cells of 6-months-old wildtype mice express mostly GluN1/GluN2A NMDARs. While synaptic NMDAR-mediated currents are unaltered in 5xFAD …
Expand your body when you look at yourself: The role of the posture in a mirror exposure task
2018
Mirror exposure (ME) is one of the main components of the treatment of patients with eating disorders symptomatology and it has shown its effectiveness in improving several outcomes (e.g., body dissatisfaction). However, the study as to what body posture should be adopted to maximize its effectiveness has been neglected. From embodied cognition and emotion theories, the adoption of an expansive (vs. contractive) body posture has been associated with positive changes in cognitive and emotional responses. The objective of this study was to analyze the effect of adopting an expansive (vs. contractive) posture before an ME task on body-related emotions and cognitions, as well as to analyze the …
Towards a cross-cultural assessment of binge-watching : Psychometric evaluation of the “watching TV series motives” and “binge-watching engagement an…
2020
International audience; In view of the growing interest regarding binge-watching (i.e., watching multiple episodes of television (TV) series in a single sitting) research, two measures were developed and validated to assess binge-watching involvement (``Binge-Watching Engagement and Symptoms Questionnaire'', BWESQ) and related motivations (``Watching TV Series Motives Questionnaire'', WTSMQ). To promote international and cross-cultural binge-watching research, the present article reports on the validation of these questionnaires in nine languages (English, French, Spanish, Italian, German, Hungarian, Persian, Arabic, Chinese). Both questionnaires were disseminated, together with additional …
Inhibition of GABA and benzodiazepine receptor binding by penicillins.
1980
Penicillins are thought to be GABA receptor antagonists. In order to determine the affinities of various penicillin derivatives for the GABA receptor, their potencies as inhibitors of specific [3H]GABA binding to rat brain membranes were investigated. All investigated penicillins inhibit specific [3H]GABA binding, with IC50 values ranging from 2 to 60 mM. The results are consistent with the assumption that penicillins are weak GABA receptor antagonists.
Conceptions of happiness and its relationship with subjective well-being: A study through Natural Semantic Networks
2018
La búsqueda de la felicidad es uno de los fines más ansiados por los seres humanos. Así mismo, cada vez son más los estudios dentro de la psicología que buscan hallar cuáles son los factores involucrados en la felicidad. Existen dos grandes enfoques para su estudio, el paradigma hedonista y el paradigma eudaimónico. El paradigma hedónico propone que el bienestar depende principalmente de vivir una vida con experiencias placenteras; mientras que el paradigma eudaimónico refiere que el bienestar no solo se logra mediante el placer, sino principalmente a través de la actualización del potencial humano. En el presente estudio se trabajó con una muestra compuesta por 340 ciudadanos de Córdoba (A…
Changing Induced Moods Via Virtual Reality
2006
Mood Induction Procedures (MIPs) are designed to induce emotional changes in experimental subjects in a controlled way, manipulating variables inside the laboratory. The induced mood should be an experimental analogue of the mood that would occur in a certain natural situation. Our team has developed an MIP using VR (VR-MIP) in order to induce different moods (sadness, happiness, anxiety and relaxation). The virtual environment is a park, which changes according to the mood to be induced. This work will present data about the efficacy of this procedure not only to induce a mood, but also to change after the mood is induced.
Suicide and Ambient Temperature: A Multi-Country Multi-City Study
2019
Background: Previous literature suggests that higher ambient temperature may play a role in increasing the risk of suicide. However, no multi-country study has explored the shape of the association and the role of moderate and extreme heat across different locations. Objectives: We examined the short-term temperature–suicide relationship using daily time-series data collected for 341 locations in 12 countries for periods ranging from 4 to 40 y. Methods: We conducted a two-stage meta-analysis. First, we performed location-specific time-stratified case-crossover analyses to examine the temperature–suicide association for each location. Then, we used a multivariate meta-regression to combine t…
Effects of the Best Possible Self intervention: A systematic review and meta-analysis
2019
The Best Possible Self (BPS) exercise promotes a positive view of oneself in the best possible future, after working hard towards it. Since the first work that attempted to examine the benefits of this intervention in 2001, studies on the BPS have grown exponentially and, currently, this is one of the most widely used Positive Psychology Interventions. However, little is yet known about its overall effectiveness in increasing wellbeing outcomes. Thus, the aim of this meta-analysis is to shed light on this question. A systematic literature search was conducted, and 29 studies (in 26 articles) met the inclusion criteria of empirically testing the intervention and comparing it to a control con…
L’ACCESSO A UNA FELICITÀ DEL POSSIBILE
2021
Una lunga riflessione sul significato di accessibilità introduce il saggio, partendo dall’etimologia del termine, assecondandone l’evoluzione e il conseguente riconoscimento istituzionale, seguendone poi gli sviluppi che danno vita a due indirizzi distinti, contestualizzabili rispettivamente nell’ambito materiale della sfera fisica e nell’ambito immateriale della sfera culturale. Quest’ultimo è l’ambito che viene approfondito e riletto attraverso la disciplina del design della comunicazione visiva. Se al concetto di accessibilità fisica si associa quello di soglia che implica il superamento di ogni tipo di barriera, limite, ostacolo, consentendo l’annullamento di soluzioni di continuità tra…
Maximizing versus satisficing in the digital age: Disjoint scales and the case for “construct consensus”
2018
Abstract A question facing us today, in the new and rapidly evolving digital age, is whether searching for the best option – being a maximizer – leads to greater happiness and better outcomes than settling on the first good enough option found – or “satisficing.” Answers to this question inform behavioural insights to improve well-being and decision-making in policy and organizational settings. Yet, the answers to this fundamental question of measurement of the happiness of a maximizer versus a satisficer in the current psychological literature are: 1) conflicting; 2) anchored on the use of the first scale published to measure maximization as an individual-difference, and 3) unable to descr…