Search results for "Pines"
showing 10 items of 421 documents
Synthesis and biological evaluation of papain-family cathepsin L-like cysteine protease inhibitors containing a 1,4-benzodiazepine scaffold as antipr…
2014
Novel papain-family cathepsin L-like cysteine protease inhibitors endowed with antitrypanosomal and antimalarial activity were developed, through an optimization study of previously developed inhibitors. In the present work, we studied the structure-activity relationships of these derivatives, with the aim to develop new analogues with a simplified and more synthetically accessible structure and with improved antiparasitic activity. The structure of the model compounds was significantly simplified by modifying or even eliminating the side chain appended at the C3 atom of the benzodiazepine scaffold. In addition, a simple methylene spacer of appropriate length was inserted between the benzod…
Bene vivere politice
2022
Abstract This chapter approaches the question of biopolitics in ancient political thought looking not at specific political techniques but at notions of the final aim of the political community. It argues that the “happiness” (eudaimonia, beatitudo) that constitutes the greatest human good in the tradition from Aristotle to Thomas Aquinas is not a “biopolitical” ideal, but rather a metabiopolitical one, consisting in a contemplative activity situated above and beyond the biological and the political. It is only with Thomas Hobbes that civic happiness becomes “biopolitically” identified with simple survival; for modernity, as Hannah Arendt puts it, mere being alive becomes the greatest human…
Liderazgo transformacional, capacidad de aprendizaje organizativo y felicidad en el trabajo
2013
En los últimos veinte años se ha producido un incremento de los artículos que buscan cómo mejorar el resultado económico en las empresas. No hay duda de la importancia que tiene esta variable como fin último de cualquier investigación, sin embargo, en este estudio queremos proponer una variable que consideramos de especial relevancia para la investigación en el área de organización de empresas como es la felicidad en el trabajo. La felicidad en general está directamente conectada con beneficios tan importantes como la salud física o mental, y las medidas que hasta ahora se han aproximado a la felicidad en el trabajo se han relacionado con variables tan importantes como la mejora de la motiv…
Development of the Happiness Index in a country
2016
[EN] In this paper, a Happiness Index is built through the Human Dignity Respect Index which is explained by Author (2014). The index is created using three main values: development, freedom and equality. But the equality is explained by solidarity, justice and peace. Then, the Happiness Index is developed with this five concepts. The aim of this paper is to obtain the minimum quantitative variables to explain these values as well as to obtain a generic formula, which allows measuring the happiness of a country/region. The term “generic” is introduced because this formula could be extrapolated to any country. The variables to obtain the Development Index are health (Life Expectancy at birth…
Operationalization of un-captured GDP - Innovation stream under new global mega-trends
2016
With the understanding that current ICT-driven global development depends on a trend shifting from traditional co-evolution of computer-initiated ICT, captured GDP, and economic functionality to new co-evolution of the Internet, un-captured GDP, and supra-functionality beyond economic value, the following hypothetical view was postulated: The disparity between the world's ICT leader countries with respect to happiness/welfare amidst great stagnation (Finland) or conspicuous economic growth (Singapore) can be attributed to the difference of the state in the above shifting trends. The foregoing hypothetical view was demonstrated on the basis of an empirical analysis measuring dependency on un…
Co-Creation of Value for IT-Enabled Services : A Case of Geocaching
2013
This study explores how value is co-created in one particular IT-enabled service, geocaching. Consumer Information Systems (CIS) framework is used as a sensitizing framework to study experienced geocachers' (n=14) perceptions of what they value in geocaching. The following core values emerged that motivate people to co-create value in geocaching: challenging oneself and others, joy of success, learning, and social relations. The results reveal that geocaching is distinctively hedonic in nature, as people pursue happiness and utility via geocaching. Even support for the geocaching community was motivated by such values. In addition, the results reveal that the environment of geocaching and s…
Sense-Making, Meaningfulness, and Instrumental Music Education
2020
The purpose of this paper is to re-examine the nature of "meaning" and "meaningfulness" in the context of instrumental music education. By doing so, I propose to expand the ways in which instrumental music educators conceive their mission and the ways in which we may instill meaning in people's lives. Traditionally, pursuits of philosophical deliberation have claimed that meaningfulness comes from either personal happiness (e.g., Jeremy Bentham and John Stuart Mill) or an impersonal sense of duty (e.g., St. Augustine, St. Thomas Aquinas, and Immanuel Kant). However, philosopher Wolf (2010) criticizes these positions in favor of a broader perspective, one that arises from understanding that …
Staphylococcus aureus alpha toxin mediates polymorphonuclear leukocyte-induced vasocontraction and endothelial dysfunction.
2002
The effect of Staphylococcus aureus alpha toxin (alpha-toxin) on selectin-mediated neutrophil adhesion was investigated in polymorphonuclear leukocyte- (PMN) induced vasocontraction and endothelial dysfunction. Adherence of human PMNs to rat aortic endothelium increased significantly following stimulation of the endothelium with alpha-toxin (0.1, 0.5, and 1 microg/mL). This effect could be significantly attenuated by monoclonal antibodies directed against P-selectin or fucoidin, a carbohydrate known to block selectins. Unstimulated human PMNs (10(6)cells/mL) were added to organ chambers containing rat aortic rings stimulated with alpha-toxin (0.5 microg/mL). PMNs elicited a significant vaso…
Fatigue, sleep, and nocturnal complaints in patients with amyotrophic lateral sclerosis
2012
Background and purpose: Fatigue is a common symptom in amyotrophic lateral sclerosis (ALS). Although sleep disturbances are a candidate factor that may interfere with fatigue in patients with ALS, the role of sleep-related abnormalities in determining fatigue in ALS is unknown. Objective: To evaluate the frequency and determinants of fatigue in a group of 91 consecutive patients with ALS, with special attention to the relationship between fatigue and sleep problems. Methods: Measures included the Fatigue Severity Scale (FSS), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), ALS Functional Rating ScaleRevised (ALSFRS-R), and Beck Depression Inventory (BDI). Results: The…
The Conceptions of Quality of Life, Wellness and Well-Being: A Literature Review
2022
In the last few years, a growing body of research has been interested in wellness, quality of life, and well-being issues. Furthermore, institutions, governments, and policymakers start to introduce numerous physical and mental well-being programs, whereas scholars interested in well-being research use different indicators to evaluate them. Although these terms are popular in the scientific debate, they are variously interpreted and at the conceptual level do not have a standard definition. This disagreement is particularly relevant when considering the questions related to their measurement and application in empirical research. This review explores the main theoretical conceptions of qual…