Search results for "Pion"
showing 10 items of 1304 documents
Effects of in vitro treatment with fluticasone propionate on natural killer and lymphokine-induced killer activity in asthmatic and healthy individua…
2001
Background: Topical corticosteroids are beneficial in the treatment of allergic respiratory disorders; they exert effects on a number of cells involved in allergic inflammatory reactions. On the other hand, major histocompatibility complex (MHC)-unrestricted cytotoxicity (i.e., natural killer [NK] cell activity) may play a role in the inflammatory allergic reaction. The objective was to gain insight into the mechanisms of the therapeutic effects of fluticasone propionate (FP), an inhaled corticosteroid used in asthma and rhinitis therapy. Therefore, we evaluated the NK and lymphokine-activated killer (LAK) activity of effector cells in vitro treated or not with FP. Methods: Evaluations were…
Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides
2012
Irreversible epidermal growth factor receptor (EGFR) inhibitors contain a reactive warhead which covalently interacts with a conserved cysteine residue in the kinase domain. The acrylamide fragment, a commonly employed warhead, effectively alkylates Cys797 of EGFR, but its reactivity can cause rapid metabolic deactivation or nonspecific reactions with off-targets. We describe here a new series of irreversible inhibitors containing a 3-aminopropanamide linked in position 6 to 4-anilinoquinazoline or 4-anilinoquinoline-3- carbonitrile driving portions. Some of these compounds proved to be as efficient as their acrylamide analogues in inhibiting EGFR-TK (TK = tyrosine kinase) autophosphorylati…
Antioxidant and neuroprotective effects of synthesized sintenin derivatives
2009
Three series of sintenin derivatives (compounds 1-14) were designed and prepared and their antioxidative and neuroprotective effects were evaluated. The in vitro models of scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, chelating ferrous ions, inhibiting the rat brain homogenates lipid peroxidation, and protecting neurons damaged by hydrogen peroxide were employed for bioassays. It was found that sintenin derivatives 4 and 13 showed remarkable antioxidative and neuroprotective activities.
Materiały do poznania fauny Kampinoskiego Parku Narodowego: Apionidae i Nanophyidae (Coleoptera: Curculionoidea)
2013
New localities of 35 species of Apionidae and 2 species of Nanophyidae in the Kampinos National Park are presented, among them respectively 26 and 2 species new for the studied area. Regarding Apionidae, 8 of 9 species recorded from the Kampinos National Park in literature, were confirmed to occur there. Perapion oblongum (GYLL.) has been recorded from the Mazovian Lowland for the first time
Il contributo delle donne allo sviluppo dell'architettura moderna
2015
Il video riguarda il ridisegno di architetture di Eileen Gray, Charlotte Perriand, Helena Syrkus, Barbara Sokolowska, Hana Kucerova, Margarette Schutte-Lihotsky, Gae Aulenti. Lina Bo Bardi, Lilly Reich, Lotte Cohn, Alison Smithson
Importance of Propionibacterium acnes hemolytic activity in human intervertebral discs: A microbiological study
2018
Most patients with chronic lower back pain (CLBP) exhibit degenerative disc disease. Disc specimens obtained during initial therapeutic discectomies are often infected/colonized with Propionibacterium acnes, a Gram-positive commensal of the human skin. Although pain associated with infection is typically ascribed to the body's inflammatory response, the Gram-positive bacterium Staphylococcus aureus was recently observed to directly activate nociceptors by secreting pore-forming α-hemolysins that disrupt neuronal cell membranes. The hemolytic activity of P. acnes in cultured disc specimens obtained during routine therapeutic discectomies was assessed through incubation on sheep-blood agar. T…
Unitary theory of the deuteron photodisintegration.
1989
The deuteron photodisintegration in the \ensuremath{\Delta}-resonance region is calculated within a unitary theory of the NN-N\ensuremath{\Delta}-\ensuremath{\pi}NN system coupled to the photon. The photoexcitation amplitude of the \ensuremath{\Delta} is deduced from the ${M}_{1+}$((3/2) pion photoproduction amplitude consistently with its background term and the \ensuremath{\pi}N interaction. The NN-N\ensuremath{\Delta} transition amplitude is obtained from the coupled equations for the NN-N\ensuremath{\Delta}-\ensuremath{\pi}NN system. The one-pion-exchange currents as well as the normal single-nucleon current are included. The polarization parameters are reproduced quantitatively, but th…
Λ(1520)andΣ(1385)in the nuclear medium
2006
Recent studies of the {lambda}(1520) resonance within chiral unitary theory with coupled channels find the resonance as a dynamically generated state from the interaction of the decuplet of baryons and the octet of mesons, essentially a quasibound state of {pi}{sigma}{sup *}(1385) in this case, although the coupling of the {lambda}(1520) to the KN and {pi}{sigma} makes this picture only approximate. The {pi}{sigma}{sup *}(1385) decay channel of the {lambda}(1520) is forbidden in free space for the nominal mass of the {sigma}{sup *}(1385), but the coupling of the {pi} to ph components in the nuclear medium opens new decay channels of the {lambda}(1520) in the nucleus and produces a much larg…
Pion photo- and electro-production and the chiral MAID interface
2016
We discuss the extended on-mass-shell scheme for manifestly Lorentz-invariant baryon chiral perturbation theory. We present a calculation of pion photo- and electroproduction up to and including order q 4 . The low-energy constants have been fixed by fitting experimental data in all available reaction channels. Our results can be accessed via a web interface, the so-called chiral MAID (http://www.kph.uni-mainz.de/MAID/chiralmaid/). We explain how our program works and how it can be used for further analysis.
Including theΔ(1232)resonance in baryon chiral perturbation theory
2005
Baryon chiral perturbation theory with explicit $\ensuremath{\Delta}(1232)$ degrees of freedom is considered. The most general interactions of pions, nucleons, and \ensuremath{\Delta} consistent with all underlying symmetries as well as with the constraint structure of higher-spin fields are constructed. By use of the extended on-mass-shell renormalization scheme, a manifestly Lorentz-invariant effective-field theory with a systematic power counting is obtained. As applications, we discuss the mass of the nucleon, the pion-nucleon \ensuremath{\sigma} term, and the pole of the \ensuremath{\Delta} propagator.