Antioxidant and neuroprotective effects of synthesized sintenin derivatives

6533b7dafe1ef96bd126e350

RESEARCH PRODUCT

Antioxidant and neuroprotective effects of synthesized sintenin derivatives

Li Hong Hu Xiao Kun Li Lijuan Zhang Joachim Stöckigt Joachim Stöckigt Leixiang Yang Xiaoyu Wang Yu Zhao Yu Zhao Ke Xin Huang

subject

Antioxidant DPPH medicine.medical_treatment Radical Neuroprotection Antioxidants Rats Sprague-Dawley Lipid peroxidation chemistry.chemical_compound Picrates Drug Discovery medicine Animals Chelation Hydrogen peroxide Cells Cultured Chelating Agents Neurons Pharmacology Chemistry Biphenyl Compounds Hydrogen Peroxide General Medicine Rats Biphenyl compound Neuroprotective Agents Biochemistry Lipid Peroxidation Propionates

description

Three series of sintenin derivatives (compounds 1-14) were designed and prepared and their antioxidative and neuroprotective effects were evaluated. The in vitro models of scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, chelating ferrous ions, inhibiting the rat brain homogenates lipid peroxidation, and protecting neurons damaged by hydrogen peroxide were employed for bioassays. It was found that sintenin derivatives 4 and 13 showed remarkable antioxidative and neuroprotective activities.

year	journal	country	edition	language
2009-04-01	Journal of Enzyme Inhibition and Medicinal Chemistry

https://doi.org/10.1080/14756360802188214

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