Search results for "Pirin"
showing 10 items of 156 documents
Rivaroxaban in Peripheral Artery Disease after Revascularization
2020
Abstract Background Patients with peripheral artery disease who have undergone lower-extremity revascularization are at high risk for major adverse limb and cardiovascular events. The efficacy and ...
Anticoagulation in Patients with Ischaemic Heart Disease and Peripheral Arterial Disease: Clinical Implications of COMPASS Study
2019
Patients with established cardiovascular disease may suffer further cardiovascular events, despite receiving optimal medical treatment. Although platelet inhibition plays a central role in the prevention of new events, the use of anticoagulant therapies to reduce events in atheromatous disease has, until recently, been overlooked. The recent Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease (COMPASS) study showed an important reduction in cardiovascular events without increasing the risk of fatal and intracranial bleeding when using rivaroxaban, a novel oral anticoagulant, combined with aspirin. This article reviews the available evidence…
Verlängerte Sekundärprophylaxe nach venöser Thromboembolie
2018
Was ist neu? Aktuelle Studien Kurz nach Absetzen der oralen Antikoagulation kommt es zu einem etwa 2- bis 3-fachen Anstieg von VTE-Rezidiven. Das Rezidivrisiko ist besonders hoch nach einer VTE, die ohne identifizierbaren Auslöser aufgetreten war oder wenn nur weiche, unsichere auslösende Risikofaktoren vorlagen, sowie bei fortbestehenden Risikofaktoren, wie z. B. einer Krebserkrankung. Konsensusdokument über auslösende Risikofaktoren für venöse Thromboembolie In einem aktuellen Konsensusdokument wurden die zugrundeliegenden Risikofaktoren definiert und in 3 Gruppen klassifiziert. Direkte orale Antikoagulanzien Eine reduzierte Dosis von DOAK ermöglicht eine wirksame verlängerte Sekundärprop…
Prehistoric Settlement and Population in the Madonie Mountains. New Data from the Archaeological Survey
2010
The aim of the Madonie research project is to analyse mobility strategies and the use of a mountainous territory by relating geomorphologic features, raw material sources and landscape to the prehistoric settlement. For this purpose we planned an intensive and systematic survey of sample areas, selected on geo-morphological, altimetric and archaeological criteria, correlated to a palaeoenvironmental investigation based on the study of palynological sequence samples coming from wet areas of the Madonie territory and from archaeological deposits. Le projet de recherche sur la Madonie analyse les stratégies de mobilité et l’exploitation du territoire de montagne, en reliant les caractéristique…
Descripción de los conodontos del Givetiense y Frasniense inferior (Devónico) de Renanué (Pirineos Aragoneses)
2001
Se estudia el contenido en conodontos del Givetiense y Frasniense inferior en la sección Renanué (Pirineos Aragoneses). Como resultado se describen 28 taxones de Polygnathus, Icriodus, Skeletognathus y Klapperina. De éstos, 21 se describen e ilustran por primera vez en la sección Renanué. Esta sucesión de conodontos permitirá una subdivisión bioestratigráfica detallada del intervalo estudiado. A Givetian and Early Frasnian conodont sequence from Renanué section is presented. As a result, 28 taxa belonging to Polygnathus, Icriodus, Skeletognathus and Klapperina are described. 21 taxa are described and illustrated for the first time from Renanué section. This conodont succession will allow a …
Stroke subtypes and their possible implication in stroke prevention drug strategies
2014
Thrombotic strokes can affect large or small arteries in the brain. Drugs to prevent atherosclerosis complication such as thrombotic strokes, should be drugs able to prevent the accumulation of intravascular fat, reduce vascular proliferation, decrease blood pressure levels with the resulting shear stress, reduce platelet aggregation, and possibly partially or totally reverse carotid plaques. Any of the commonly used antihypertensive drugs lower the incidence of stroke, with larger reductions in BP resulting in larger reductions in risk. Experimental and clinical data suggest that reducing the activity of the renin-angiotensin aldosterone system (RAAS) may have beneficial effects beyond the…
Fabrication, characterization, thermal stability and nanoassemblies of novel pullulan-aspirin conjugates
2017
Abstract Present study deals with homogeneous and one-pot synthesis of novel macromolecular prodrugs (MPDs) of aspirin onto naturally occurring hydrophilic biopolymer pullulan. Pullulan-aspirin conjugates were synthesized by using green carboxylic acid activating reagent 1,1′-carbonyldiimidazole (CDI). The aspirin was first reacted with CDI to prepare aspirin-imidazolide at RT for 24 h which in situ reacted with pre-dissolved pullulan and the reaction preceded further for 24 h at 80 °C under nitrogen. Degree of substitution (DS 0.32–0.40) of aspirin onto pullulan was calculated from 1H NMR spectroscopy. Spectroscopic techniques confirmed the high covalent drug loading and purity. Thermal an…
Are Anticoagulants and Antiplatelet Agents Important in Thoracic Surgery?
2020
The management of antithrombotic drugs (antiplatelet and anticoagulant agents) is a common challenging issue in patients undergoing thoracic surgery. The procedure can require the temporary interruption of these drugs because of their associated haemorrhagic risk, therefore assuming a thrombotic risk also. The assessment of the balance between both risks gives us their optimal management.
Effect of aspirin on renal disease progression in patients with type 2 diabetes: A multicenter, double-blind, placebo-controlled, randomized trial. T…
2017
Background Type 2 diabetes mellitus (T2DM) is one of the most common causes of chronic kidney disease and kidney failure. It has been estimated that the annual decline of estimated glomerular filtration rate (eGFR) among patients with T2DM is approximately 2.0-2.5 mL min−1 y−1. Cyclooxygenase-dependent eicosanoids, such as 11-dehydro-thromboxane (Tx)B2, are increased in T2DM patients and are potentially involved in the regulation of renal blood flow. Animal models showed that cyclooxygenase inhibitors, such as aspirin, are associated with improvements in renal plasma flow and eGFR values. Hypothesis The primary end point of the LEDA trial is to evaluate the 1-year decline of eGFR in T2DM pa…
Viage del Rey nuestro señor Don Felipe Quarto el Grande, a la frontera de Francia : funciones reales, del desposorio, y entregas de la Serenissima se…
Front. calc. : "P.V.F. 1667" Hi ha estats sense signatura ni data en front Gravs. cac en f. de làm.: "P. a Villafranca sculptor sculptor Regius sculp. M. 1667", retrats de Carles I, Felip IV, Ana d'Austria, Luis XIV i Maria Teresa d'Austria Grav. calc. pleg. "Vnionis dominis super flumen Vidasoa", de 36x48 mm Sign.: §-§§§4, A-Z4, Aa-Oo4, A-K4, L2