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showing 10 items of 316 documents

Genetic structure and demographic inference of the regular sea urchin Sterechinus neumayeri (Meissner, 1900) in the Southern Ocean: the role of the l…

2018

22 pages; International audience; One of the most relevant characteristics of the extant Southern Ocean fauna is its resiliency to survive glacial processes of the Quaternary. These climatic events produced catastrophic habitat reductions and forced some marine benthic species to move, adapt or go extinct. The marine benthic species inhabiting the Antarctic upper continental shelf faced the Quaternary glaciations with different strategies that drastically modified population sizes and thus affected the amount and distribution of intraspecific genetic variation. Here we present new genetic information for the most conspicuous regular sea urchin of the Antarctic continental shelf, Sterechinus…

Gene FlowTopographyHeredityEcological MetricsPopulation geneticsOceans and SeasGenetic locilcsh:MedicineDNA MitochondrialGeographical LocationsBodies of waterOceansGeneticsAnimalslcsh:ScienceEcosystemSpecies diversityPopulation DensityIslandsEvolutionary BiologyLandforms[SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE]Population BiologyGeographyEcologylcsh:REcology and Environmental SciencesBiology and Life SciencesGeomorphologyBayes TheoremMarine and aquatic sciencesGenetic MappingPhylogeographyAntarctic OceanGenetics PopulationBiogeographyHaplotypesSea UrchinsPeople and PlacesEarth SciencesAntarcticalcsh:QResearch Article
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Mediterranean diet adherence and synergy with acute myocardial infarction and its determinants: A multicenter case-control study in Italy

2018

Background Cardiovascular diseases are the leading causes of mortality and morbidity in Western countries. The possible synergistic effect of poor adherence to a Mediterranean diet (MD) and other risk factors for acute myocardial infarction (AMI) such as hypertension, cholesterol, ever smoker, BMI> 25, diabetes, has not been deeply studied. Design Case-control study. Methods Patients with first AMI and controls from four tertiary referral Italian centers were screened for enrolment. Dietary information was collected through a questionnaire and a MD adherence score was calculated. Physical activity and smoking habits were also registered. The Synergy Index was calculated according to Rothman…

Genetics and Molecular Biology (all)MaleMultivariate analysisMediterranean dietTertiary Care CenterMyocardial Infarctionlcsh:MedicineBlood PressureMediterranean030204 cardiovascular system & hematologyPathology and Laboratory MedicineDiet MediterraneanVascular MedicineBiochemistryGeographical locationsTertiary Care CentersHabitschemistry.chemical_compoundEndocrinology0302 clinical medicineRisk FactorsSurveys and QuestionnairesMedicine and Health SciencesSmoking HabitsSurveys and Questionnaire030212 general & internal medicineMyocardial infarctionlcsh:ScienceMultidisciplinarySmokingMiddle AgedEuropeHyperlipidemiaItalyResearch DesignSettore MED/42HypertensionFemaleCase-Control StudieHumanResearch Articlemedicine.medical_specialtyAged; Case-Control Studies; Feeding Behavior; Female; Humans; Hypertension; Italy; Male; Middle Aged; Myocardial Infarction; Risk Factors; Smoking; Surveys and Questionnaires; Tertiary Care Centers; Diet Mediterranean; Patient ComplianceReferralEndocrine DisordersSmoking habitHypercholesterolemiaCardiologyResearch and Analysis Methods03 medical and health sciencesSigns and SymptomsDiagnostic MedicineDiabetes mellitusInternal medicineDiabetes MellitusAged; Case-Control Studies; Feeding Behavior; Female; Humans; Hypertension; Italy; Male; Middle Aged; Myocardial Infarction; Risk Factors; Smoking; Surveys and Questionnaires; Tertiary Care Centers; Diet Mediterranean; Patient Compliance; Biochemistry Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)medicineHumansEuropean UnionNutritionAgedBehaviorCholesterolbusiness.industryRisk Factorlcsh:RCase-control studyBiology and Life SciencesFeeding Behaviormedicine.diseaseDietAgricultural and Biological Sciences (all)chemistryMetabolic DisordersCase-Control StudiesPatient Compliancelcsh:QPeople and placesbusinessPLOS ONE
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Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy

2018

Background For many years, long-acting intramuscular (LAI) antipsychotics have been prescribed predominantly to chronic and severe patients, as a last resort when other treatments failed. Recently, a broader and earlier use of LAIs, particularly second-generation LAIs, has been emphasized. To date, few studies attempted to frame how this change in prescribing took place in real-world practice. Therefore, this study aimed to describe the clinical features of patients prescribed with LAIs, and to explore possible prescribing differences between first- and second-generations LAIs under ordinary clinical practice in Italy. Methods The STAR Network "Depot" Study is an observational, longitudinal…

Genetics and Molecular Biology (all)MalePediatricsEuropean PeopleBipolar DisorderCross-sectional studyEconomicsEpidemiologymedicine.medical_treatmentassessmentviruseslcsh:MedicineSocial SciencesLongitudinal StudieBiochemistryPrescriptionGeographical locations0302 clinical medicineMathematical and Statistical TechniquesBiochemistry Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)immune system diseasesEpidemiologyMedicine and Health Scienceslong-acting intramuscular (LAI) antipsychotics; clinical practice; assessment; second-generation antipsychotic (SGA) LAIsAntipsychoticsEthnicitiesLongitudinal Studieslcsh:ScienceMultidisciplinaryvirus diseasesDrugsMiddle Agedclinical practiceItalian PeopleEuropePrescriptionsItalyPhysical SciencesAripiprazoleFemaleBivariate AnalysisStatistics (Mathematics)medicine.drugHumanResearch ArticleAntipsychotic AgentsEmploymentAdultmedicine.medical_specialtyAdolescentResearch and Analysis Methods03 medical and health sciencesMental Health and PsychiatrymedicineHumansPaliperidoneBipolar disorderEuropean UnionStatistical MethodsAntipsychoticCross-Sectional StudiePharmacologyRisperidoneBiochemistry Genetics and Molecular Biology (all)business.industryMood Disorderslcsh:Rmedicine.disease030227 psychiatryAntipsychotic AgentCross-Sectional StudiesAgricultural and Biological Sciences (all)Labor EconomicsMultivariate AnalysisSchizophreniaObservational studylcsh:QPopulation Groupingslong-acting intramuscular (LAI) antipsychoticsPeople and placesbusiness030217 neurology & neurosurgerysecond-generation antipsychotic (SGA) LAIsMathematicsPLoS ONE
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Testing and comparing two self-care-related instruments among older Chinese adults

2017

Objectives The study aimed to test and compare the reliability and validity, including sensitivity and specificity of the two self-care-related instruments, the Self-care Ability Scale for the Elderly (SASE), and the Appraisal of Self-care Agency Scale-Revised (ASAS-R), among older adults in the Chinese context. Methods A cross-sectional design was used to conduct this study. The sample consisted of 1152 older adults. Data were collected by a questionnaire including the Chinese version of SASE (SASE-CHI), the Chinese version of ASAS-R (ASAS-R-CHI) and the Exercise of Self-Care Agency scale (ESCA). Homogeneity and stability, content, construct and concurrent validity, and sensitivity and spe…

GerontologyMaleAgingResearch ValidityPhysiologylcsh:MedicineGeographical LocationsHabitsElderlySurveys and QuestionnairesStatisticsContent validityMedicine and Health SciencesMedicineEthnicitieslcsh:ScienceGeriatricsCognitive ImpairmentAged 80 and overMultidisciplinary030504 nursingCognitive Neurology030503 health policy & servicesResearch AssessmentMiddle AgedNeurologyFemale0305 other medical scienceResearch Articlemedicine.medical_specialtyChinaAsiaCorrelation coefficientPsychometricsCognitive NeuroscienceConcurrent validityResearch and Analysis MethodsSensitivity and Specificity03 medical and health sciencesCronbach's alphaHumansRank correlationAgedBehaviorReceiver operating characteristicbusiness.industrylcsh:RConstruct validityBiology and Life SciencesReproducibility of ResultsSelf CareCross-Sectional StudiesAge GroupsGeriatricsPeople and PlacesCognitive Sciencelcsh:QPopulation GroupingsbusinessPhysiological ProcessesOrganism DevelopmentChinese PeopleNeuroscienceDevelopmental BiologyPLoS ONE
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Who is ‘on-call’ in Australia? A new classification approach for on-call employment in future population-level studies

2021

Background On-call research and guidance materials typically focus on ‘traditional’ on-call work (e.g., emergency services, healthcare). However, given the increasing prevalence of non-standard employment arrangements (e.g., gig work and casualisation), it is likely that a proportion of individuals who describe themselves as being on-call are not included in current on-call literature. This study therefore aimed to describe the current sociodemographic and work characteristics of Australian on-call workers. Methods A survey of 2044 adults assessed sociodemographic and work arrangements. Of this population, 1057 individuals were workforce participants, who were asked to provide information …

GerontologyMaleEmergency Medical ServicesPopulation levelEconomicsSocial SciencesSurveysSociologySurveys and QuestionnairesHealth carePsychologyWorkplaceData ManagementLanguageeducation.field_of_studyMultidisciplinarySchoolsQRMiddle AgedProfessionsWork (electrical)Social systemResearch DesignWorkforceSocial SystemsWorkforceMedicineFemalePsychologyResearch ArticleEmploymentAdultComputer and Information SciencesSociodemographic FactorsAdolescentSciencePopulationJobsResearch and Analysis MethodsEducationYoung AdultTaxonomy (general)HumansOccupationseducationSet (psychology)TaxonomySurvey Researchbusiness.industryCognitive PsychologyAustraliaBiology and Life SciencesLabor EconomicsPeople and PlacesCognitive SciencePopulation GroupingsbusinessDelivery of Health CareNeurosciencePLoS ONE
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Is quality of life different between diabetic and non-diabetic people? The importance of cardiovascular risks.

2017

BackgroundTo analyse and compare the impact of cardiovascular risk factors and disease on health-related quality of life (HRQoL) in people with and without diabetes living in the community.MethodsWe used data of 1,905 people with diabetes and 19,031 people without diabetes from the last Spanish National Health Survey (years 2011 +/- 2012). The HRQoL instrument used was the EuroQol 5D-5L, based on time trade-off scores. Matching methods were used to assess any differences in the HRQoL in people with and without diabetes with the same characteristics (age, gender, education level, and healthy lifestyle), according to cardiovascular risk factors and diseases. Disparities were also analysed for…

GerontologyMaleEuropean PeopleActivities of daily livingSpanish PeoplePhysiologylcsh:MedicineEXPECTANCYDiseaseCardiovascular MedicineSurveysEndocrinology0302 clinical medicineQuality of lifeRisk FactorsMedicine and Health SciencesEthnicitiesMedicine030212 general & internal medicinelcsh:ScienceHispanic PeopleDepression (differential diagnoses)Multidisciplinary030503 health policy & servicesMiddle AgedhumanitiesPhysiological ParametersNeurologySINGLEResearch DesignCardiovascular DiseasesFemaleHEALTH0305 other medical scienceResearch ArticleEndocrine DisordersResearch and Analysis Methods03 medical and health sciencesDiabetes mellitusDiabetes MellitusHumansObesityRisk factorOLDERSurvey Researchbusiness.industryBody Weightlcsh:RHealth Risk AnalysisBiology and Life Sciencesmedicine.diseaseHealth SurveysObesityNeuropathyHealth CareBODY-MASS INDEXMetabolic DisordersCase-Control StudiesPeople and PlacesQuality of LifePopulation Groupingslcsh:QbusinessBody mass indexCOSTS
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A national study on the physical and mental health of intersex adults in the U.S.

2020

ObjectivesTo describe the health of intersex adults (people with differences of sex development) in the U.S. using community-based research methods.MethodsIn July-September 2018, we conducted a national health study of intersex adults aged 18 and older in the U.S., using a survey hosted on Qualtrics. The study describes the physical and mental health experiences of intersex adults, including differences by age (18 to 39 vs. 40 and older). Questions were derived from national (Behavioral Risk Factor Surveillance System) and intersex-related health studies.ResultsA non-probability sample of 198 intersex adults completed the survey over three months. Over 43% of participants rated their physic…

GerontologyMaleendocrine system diseasesHealth StatusDisorders of Sex DevelopmentSocial SciencesSurveysurologic and male genital diseasesSurveys and QuestionnairesMedicine and Health SciencesMedicinePsychologyPublic and Occupational HealthYoung adultDepression (differential diagnoses)MultidisciplinaryBehavioral Risk Factor Surveillance SystemDepressionQRGender IdentityMiddle AgedAnxiety DisordersHealth equitySocioeconomic Aspects of HealthSuicideMental HealthResearch DesignMedicineAnxietyLife course approachFemalemedicine.symptomResearch ArticleAdultendocrine systemAdolescentScienceMEDLINENeuropsychiatric DisordersResearch and Analysis MethodsNeurosesYoung AdultMental Health and PsychiatryHumansAgedSurvey Researchbusiness.industryurogenital systemMood DisordersBiology and Life SciencesMental healthUnited StatesHealth CareLogistic ModelsAge GroupsPeople and PlacesPopulation GroupingsbusinessPLoS ONE
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Quantifying Excess Deaths Related to Heatwaves under Climate Change Scenarios: A multicountry time series modelling study

2018

Background: Heatwaves are a critical public health problem. There will be an increase in the frequency and severity of heatwaves under changing climate. However, evidence about the impacts of climate change on heatwave-related mortality at a global scale is limited. Methods and findings: We collected historical daily time series of mean temperature and mortality for all causes or nonexternal causes, in periods ranging from January 1, 1984, to December 31, 2015, in 412 communities within 20 countries/regions. We estimated heatwave–mortality associations through a two-stage time series design. Current and future daily mean temperature series were projected under four scenarios of greenhouse g…

Greenhouse EffectAtmospheric ScienceTime Factors010504 meteorology & atmospheric sciencesHot temperature010501 environmental sciences01 natural sciencesGeographical LocationsJapanRisk FactorsCause of Death11. SustainabilityMedicine and Health SciencesPublic and Occupational Healthskin and connective tissue diseasesHeat related mortalityClimatologyTemperaturesRGeneral MedicineEuropeChemistryclimate changeClimatologyPhysical SciencesMedicineBehavioral and Social Aspects of HealthRisk assessmentResearch ArticleEnvironmental Monitoringcarbon footprintDeath RatesClimate ChangeClimate changemacromolecular substancesColombiaRisk AssessmentGreenhouse GasesArbetsmedicin och miljömedicinPopulation MetricsGeneral & Internal MedicineHeat-related mortalitydeathEnvironmental ChemistryHumanscontrolled studyhuman0105 earth and related environmental sciencesBehaviorPopulation BiologyEcology and Environmental SciencesGlobal warmingMUDANÇA CLIMÁTICABiology and Life SciencesEnvironmental ExposureOccupational Health and Environmental HealthMoldovaTime series modellingMoldovamortalitytime series analysisuncertaintyUnited StatesMulticenter study13. Climate actionAtmospheric ChemistryGreenhouse gasPeople and PlacesEarth SciencesEnvironmental scienceClimate modeldisease simulationsense organsEnvironmental SciencesClimate Modeling
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Ancient Haplotypes at the 15q24.2 Microdeletion Region Are Linked to Brain Expression of MAN2C1 and Children's Intelligence

2016

The chromosome bands 15q24.1-15q24.3 contain a complex region with numerous segmental duplications that predispose to regional microduplications and microdeletions, both of which have been linked to intellectual disability, speech delay and autistic features. The region may also harbour common inversion polymorphisms whose functional and phenotypic manifestations are unknown. Using single nucleotide polymorphism (SNP) data, we detected four large contiguous haplotype-genotypes at 15q24 with Mendelian inheritance in 2,562 trios, African origin, high population stratification and reduced recombination rates. Although the haplotype-genotypes have been most likely generated by decreased or abse…

HeredityAutism Spectrum DisorderIntelligenceSocial SciencesChromosome DisordersMAN2C1 geneFamiliesMicePsychologylcsh:ScienceChildChildrenIn Situ HybridizationCognitive ImpairmentIntelligence Testseducation.field_of_studyIntelligence quotientBrainGenomicsNeurologyChromosome DeletionHumanGenotypeEvolutionSingle-nucleotide polymorphismFluorescenceEvolution Molecular03 medical and health sciencesalpha-MannosidaseIntellectual DisabilityMannosidasesGeneticsChromosome 15q24 2HumansPolymorphismeducationChromosome Aberrationslcsh:RHaplotypePair 15PongoBiology and Life SciencesComputational BiologyMolecularmedicine.diseaseIntellectual Disability/genetics030104 developmental biologyNeurodevelopmental DisordersDevelopmental PsychologyAfricalcsh:QPopulation GroupingsGene expressionEthiopiaAutismePopulation GeneticsNeuroscience0301 basic medicineAutismlcsh:MedicineGene ExpressionHomozygosityGeographical LocationsCohort StudiesChromosome Disorders/geneticsIntellectual disabilityMedicine and Health SciencesIn Situ Hybridization FluorescenceSegmental duplicationMannosidases/geneticsGeneticsMultidisciplinaryGenomeCognitive NeurologyHomozygoteSingle NucleotidePhenotypesymbolsInfantsResearch ArticleCognitive NeurosciencePopulationInfants -- DesenvolupamentBiologyPolymorphism Single NucleotideChromosomessymbols.namesakeDevelopmental NeurosciencemedicineAnimalsBrain/metabolismCromosomes humans -- AnomaliesAlleleChromosomes Human Pair 15Evolutionary BiologyPopulation BiologyGenome HumanChromosome 15qIntelligence/geneticsGenome AnalysisGenomic LibrariesExpressió gènicaMacaca mulattaRatsHaplotypesAge GroupsPeople and PlacesMendelian inheritanceCognitive Science
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Correction: Phylogeny of the Eurasian Wren Nannus troglodytes (Aves: Passeriformes: Troglodytidae) reveals deep and complex diversification patterns …

2020

The Mediterranean Basin represents a Global Biodiversity Hotspot where many organisms show high inter- and intraspecific differentiation. Extant phylogeographic patterns of terrestrial circum-Mediterranean faunas were mainly shaped through Pleistocene range shifts and range fragmentations due to retreat into different glacial refugia. Thus, several extant Mediterranean bird species have diversified by surviving glaciations in different hospitable refugia and subsequently expanded their distribution ranges during the Holocene. Such a scenario was also suggested for the Eurasian Wren (Nannus troglodytes) despite the lack of genetic data for most Mediterranean subspecies. Our phylogenetic mult…

HeredityBiochemistryGeographical LocationsSongbirdsPleistocene EpochAfrica NorthernEnergy-Producing OrganellesPhylogenyData ManagementMultidisciplinaryQuaternary PeriodGeographyFossilsQRPhylogenetic AnalysisGeologyBiodiversityBiological EvolutionFossil CalibrationMitochondriaPhylogeneticsEuropeGenetic MappingPhylogeographyBiogeographyMedicineCellular Structures and OrganellesResearch ArticleGenetic MarkersComputer and Information SciencesMitochondria ; Fossil calibration ; Haplotypes ; Europe ; Phylogenetic analysis ; Phylogeography ; Paleogenetics ; Pleistocene epochScienceBioenergeticsDNA MitochondrialGeneticsAnimalsEvolutionary SystematicsTaxonomyEvolutionary BiologyPopulation BiologyEcology and Environmental SciencesBiology and Life SciencesPaleontologyCorrectionGenetic VariationGeologic TimeCell BiologyHaplotypesPeople and PlacesEarth SciencesCenozoic EraPaleogeneticsPopulation Genetics
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