Search results for "Plant Bark"

showing 2 items of 32 documents

Spirocurcasone, a diterpenoid with a novel carbon skeleton from Jatropha curcas.

2010

Spirocurcasone (14), a diterpenoid possessing the unprecedented "spirorhamnofolane" skeleton, was isolated from the root barks of Jatropha curcas, a plant extensively cultivated throughout the world, along with 11 known and two other new diterpenoids. The stereostructure of spirocurcasone was established using HRESIMS, NMR, and quantum mechanical calculation of the electronic circular dichroic (ECD) spectrum. Some of the isolated diterpenoids showed a potent activity against L5178Y, a mouse lymphoma cell line.

biologyPlant rootsMolecular StructureChemistryMouse LymphomaOrganic ChemistryCarbon skeletonJatrophaJatrophabiology.organism_classificationBiochemistryAntineoplastic Agents PhytogenicPlant RootsTerpenoidMicePlant BarkOrganic chemistryAnimalsPhysical and Theoretical ChemistryDiterpenesDrug Screening Assays AntitumorJatropha curcasSpirocurcasoneOrganic letters
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Botanicals and phytochemicals from the bark of Hypericum roeperianum (Hypericaceae) had strong antibacterial activity and showed synergistic effects …

2021

Abstract Ethnopharmacological relevance Infections due to multidrug-resistant (MDR) bacteria constitute a real problem in the public health worldwide. Hypericum roeperianum Schimp. ex A. Rich (Hypericaceae) is used traditionally for treatment of various ailments such as abdominal pains, constipation, diarrhea, indigestion, nausea, and bacterial diseases. Aim of the study This study was aimed at investigating the antibacterial and antibiotic-modifying activity of the crude methanol extracts (HRB), ethyl-acetate soluble fraction (HRBa), residual material (HRBb), and 11 compounds from the bark of Hypericum roeperianum against multi-drug resistant (MDR) bacteria expressing active efflux pumps. …

medicine.drug_classTetracyclinePhytochemicalsAntibioticsMicrobial Sensitivity Tests03 medical and health sciences0302 clinical medicineDrug Resistance Multiple BacterialDrug Discoverymedicine030304 developmental biologyPharmacologyDoxycycline0303 health sciencesBacteriaTraditional medicinebiologyPlant ExtractsChemistryMembrane Transport ProteinsDrug Synergismbiology.organism_classificationAnti-Bacterial AgentsMultiple drug resistancePhytochemical030220 oncology & carcinogenesisPlant BarkEffluxAntibacterial activityHypericumBacteriamedicine.drugJournal of Ethnopharmacology
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