Search results for "Poiesis"
showing 9 items of 299 documents
Transcription factors controlling development and function of innate lymphoid cells.
2014
Abstract Innate lymphoid cells (ILCs) are a heterogeneous group of lymphocytes, which play an important role in tissue homeostasis at epithelial surfaces. They are scarce in spleen and lymph nodes, but substantial numbers can be found in the intestinal mucosa even at steady state. There, they represent the first line of defence against invading pathogens and contribute to lymphorganogenesis, tissue repair and, when inappropriately activated, immune pathology. Lineage-specific development, function and maintenance of these cells depend on a restricted set of transcription factors that partially emerged as a result of diversification and selection during vertebrate evolution. The differential…
CD40 activity on mesenchymal cells negatively regulates OX40L to maintain bone marrow immune homeostasis under stress conditions
2021
BackgroundWithin the bone marrow (BM), mature T cells are maintained under homeostatic conditions to facilitate proper hematopoietic development. This homeostasis depends upon a peculiar elevated frequency of regulatory T cells (Tregs) and immune regulatory activities from BM-mesenchymal stem cells (BM-MSCs). In response to BM transplantation (BMT), the conditioning regimen exposes the BM to a dramatic induction of inflammatory cytokines and causes an unbalanced T-effector (Teff) and Treg ratio. This imbalance negatively impacts hematopoiesis, particularly in regard to B-cell lymphopoiesis that requires an intact cross-talk between BM-MSCs and Tregs. The mechanisms underlying the ability of…
Mesenchymal Stem Cells Provide Better Results Than Hematopoietic Precursors for the Treatment of Myocardial Infarction
2010
Objectives The purpose of this study was to compare the ability of human CD34(+) hematopoietic stem cells and bone marrow mesenchymal stem cells (MSC) to treat myocardial infarction (MI) in a model of permanent left descendent coronary artery (LDA) ligation in nude rats. Background Transplantation of human CD34(+) cells and MSC has been proved to be effective in treating MI, but no comparative studies have been performed to elucidate which treatment prevents left ventricular (LV) remodelling more efficiently. Methods Human bone marrow MSC or freshly isolated CD34(+) cells from umbilical cord blood were injected intramyocardially in infarcted nude rats. Cardiac function was analyzed by echoc…
Pašvaldība kā pašregulējoša sistēma
2016
Maģistra darba nosaukums ir “Pašvaldība kā pašregulējoša sistēma”. Darba mērķis ir izpētīt, vai Latvijas pašvaldības pēc to darbības, ir uzskatāmas par pašregulējošām sistēmām. Dotā darba uzdevumi: sniegt teorētisko bāzi par pašregulējošu sistēmu; meklēt pazīmes, kuras raksturo sociālo vidi caur šo sistēmu; noteikt kritērijus, pēc kuriem tiks veikta Jūrmalas, Daugavpils un Ventspils pilsētu pašvaldību gadījumu analīze, tā parādot, kā izvēlētie kritēriji izpaužas šo pašvaldību gadījumā. Rezultāti norāda uz to, ka pašvaldības var uzskatīt par pašregulējošām sistēmām. Atslēgas vārdi: Latvijas pašvaldības, pašregulējoša sistēma (autopoiesis)
Hacia una metodología del análisis crítico del discurso desde la enacción aplicada al género y la traducción: Una visión liminar en Bridget Jones. Ma…
2023
En esta investigación se abordan los presupuestos biológico-cognitivos de la Enacción y se refieren a un sistema lingüístico-perceptivo mediante la Gramática Liminar (GL) y el Análisis Crítico del Discurso (ACD) aplicado al estudio enactivo entre Bridget Jones. Mad about The Boy (2013) y Bridget Jones. Loca por él, de H. Fielding. Analizamos cómo la enacción sexista resulta de la forma sistémica de comunicarnos, incardinada en el cuerpo como matriz cognitiva biológica-cultural, donde el lenguaje actúa como bucle de retroalimentación en perpetua intratraducción entre el ser/mundo y viceversa, y se configura en lenguas de cuya intertraducción depende el grado de connotación sexista. This rese…
Extramedullary hematopoiesis within endothelial papillary hyperplasia (Masson?s pseudoangiosarcoma) of the tongue
2007
We report the unique association of Masson?s pseudoangiosarcoma (endothelial papillary hyperplasia) and extramedullary hematopoiesis. The lesion was present as a violaceous nodule on the side of the tongue of a 78-year-old man with history of multiple myeloma and long-standing mild anemia. This association between a peculiar form of thrombus organization and extramedullary hematopoiesis has been reported previously only once, in an infant with a cranial hematoma, and raises interesting pathogenetic questions.
Role of hematopoietic stem and progenitor cells in training immunity against infection
2022
During an infection, haematopoiesis is altered to increase the output of mature myeloid cells to fight off the pathogen. It has been demonstrated that the detection of pattern recognition receptor agonists by hematopoietic stem and progenitor cells (HSPCs) induces their differentiation towards mature myeloid cells with modified phenotypes. In the present PhD thesis, we show that an in vitro transient exposure of HSPCs to live Candida albicans cells is sufficient to induce a trained phenotype of the macrophages they produce in a dectin-1- and TLR2-dependent manner. Additionally, we use an HSPC transplantation mouse model to demonstrate that the direct interaction of β-glucans and their recep…
L'Ecuba euripidea: dramma della violenza sugli inermi
2010
This paper focuses on ‘violence on unarmed people’ as the unifying theme that underlies the structure of the tragedy with an anthropopoietic function, what means to build up, by contrast, models of human and humanity.. All the three forms of violence against unarmed people, which can be singled out in the tragedy, are analyzed. The first is the sacred violence of Polyxena’s sacrifice, which is represented as an unnecessary and avoidable killing, due to the excessive power of the winners Greeks on losers barbarians. The second is the criminal violence upon Polydorus, motivated by greed for gold but also due to the impunity in a destructive war. The third is the ‘maenadic’ violence by which H…
Mouse models of cytomegalovirus latency: overview.
2002
Abstract Background: The molecular regulation of viral latency and reactivation is a central unsolved issue in the understanding of cytomegalovirus (CMV) biology. Like human CMV (hCMV), murine CMV (mCMV) can establish a latent infection in cells of the myeloid lineage. Since mCMV genome remains present in various organs after its clearance from hematopoietic cells first in bone marrow and much later in blood, there must exist one or more widely distributed cell type(s) representing the cellular site(s) of enduring mCMV latency in host tissues. Endothelial cells and histiocytes are candidates, but the question is not yet settled. Another long debated problem appears to be solved: mCMV establ…