Search results for "Polarization"
showing 10 items of 1884 documents
Chronically elevated branched chain amino acid levels are pro-arrhythmic.
2022
Aim. Cardiac arrhythmias comprise a major health and economic burden and are associated with significant morbidity and mortality, including cardiac failure, stroke and sudden cardiac death (SCD). Development of efficient preventive and therapeutic strategies is hampered by incomplete knowledge of disease mechanisms and pathways. Our aim is to identify novel mechanisms underlying cardiac arrhythmia and SCD using an unbiased approach. Methods and Results. We employed a phenotype-driven N-ethyl-N-nitrosourea (ENU) mutagenesis screen and identified a mouse line with a high incidence of sudden death at young age (6-9 weeks) in the absence of prior symptoms. Affected mice were found to be homozyg…
2021
Background: Immunomodulatory properties of bisphosphonates (BP) are suggested to contribute to the development of medication-associated osteonecrosis of the jaw (MRONJ). Furthermore, bisphosphonate-derived immune modulation might contribute to the anti-metastatic effect observed in breast cancer patients. Macrophages are potential candidates for the mediation of immunomodulatory effects of bisphosphonates. The study aimed to investigate the influence of bisphosphonates alone and in combination with surgical trauma on systemic macrophage polarization (M1 vs. M2) using an in vivo rat model. Methods: A total of 120 animals were divided into four groups. Groups 2 and 4 were treated with 8 × 40 …
Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors
2017
This article provides a review of the effects of activation of muscarinic and nicotinic receptors on the physiological properties of circuits in the hippocampal formation. Previous articles have described detailed computational hypotheses about the role of cholinergic neuromodulation in enhancing the dynamics for encoding in cortical structures and the role of reduced cholinergic modulation in allowing consolidation of previously encoded information. This article will focus on addressing the broad scope of different modulatory effects observed within hippocampal circuits, highlighting the heterogeneity of cholinergic modulation in terms of the physiological effects of activation of muscarin…
More than a pore: How voltage-gated calcium channels act on different levels of neuronal communication regulation.
2021
ABSTRACT Voltage-gated calcium channels (VGCCs) represent key regulators of the calcium influx through the plasma membrane of excitable cells, like neurons. Activated by the depolarization of the membrane, the opening of VGCCs induces very transient and local changes in the intracellular calcium concentration, known as calcium nanodomains, that in turn trigger calcium-dependent signaling cascades and the release of chemical neurotransmitters. Based on their central importance as concierges of excitation-secretion coupling and therefore neuronal communication, VGCCs have been studied in multiple aspects of neuronal function and malfunction. However, studies on molecular interaction partners …
Nonlinear femtosecond pulse propagation in an all-solid photonic bandgap fiber
2009
Nonlinear femtosecond pulse propagation in an all-solid photonic bandgap fiber is experimentally and numerically investigated. Guiding light in such fiber occurs via two mechanisms: photonic bandgap in the central silica core or total internal reflection in the germanium doped inclusions. By properly combining spectral filtering, dispersion tailoring and pump coupling into the fiber modes, we experimentally demonstrate efficient supercontinuum generation with controllable spectral bandwidth.
Rho resonance, timelike pion form factor, and implications for lattice studies of the hadronic vacuum polarization
2020
We study isospin-1 P-wave ππ scattering in lattice QCD with two flavors of O(a) improved Wilson fermions. For pion masses ranging from mπ=265 MeV to mπ=437 MeV, we determine the energy spectrum in the center-of-mass frame and in three moving frames. We obtain the scattering phase shifts using Lüscher’s finite-volume quantization condition. Fitting the dependence of the phase shifts on the scattering momentum to a Breit-Wigner form allows us to determine the corresponding ρ mass mρ and gρππ coupling. By combining the scattering phase shifts with the decay matrix element of the vector current, we calculate the timelike pion form factor, Fπ, and compare the results to the Gounaris-Sakurai repr…
Polarization types of isogenous Prym-Tyurin varieties
2007
Let p:C-->Y be a covering of smooth, projective curves which is a composition of ��:C-->C' of degree 2 and g:C'-->Y of degree n. Let f:X-->Y be the covering of degree 2^n, where the curve X parametrizes the liftings in C^{(n)} of the fibers of g:C'-->Y. Let P(X,��) be the associated Prym-Tyurin variety, known to be isogenous to the Prym variety P(C,C'). Most of the results in the paper focus on calculating the polarization type of the restriction of the canonical polarization of JX on P(X,��). We obtain the polarization type when n=3. When Y=P^1 we conjecture that P(X,��) is isomorphic to the dual of the Prym variety P(C,C'). This was known when n=2, we prove it when n=3, and…
"P_AntiLambda vs. centrality (2.76 TeV)" of "Global polarization of $\Lambda$ and $\overline{\Lambda}$ hyperons in Pb-Pb collisions at the LHC"
2021
The $\bar\Lambda$ global polarization as function of centrality for Pb-Pb collisions at $\sqrt{s_{\mathrm{NN}}}=2.76$~TeV.
"P_AntiLambda vs. pT (2.76TeV, 5-15%)" of "Global polarization of $\Lambda$ and $\overline{\Lambda}$ hyperons in Pb-Pb collisions at the LHC"
2021
The $\bar\Lambda$ global polarization as function of transverse momentum ($p_{\mathrm{T}}$) for 5-15% centrality in Pb-Pb collisions at $\sqrt{s_{\mathrm{NN}}}=2.76$~TeV.
"P_Lambda vs. pT (2.76TeV, 5-15%)" of "Global polarization of $\Lambda$ and $\overline{\Lambda}$ hyperons in Pb-Pb collisions at the LHC"
2021
The $\Lambda$ global polarization as function of transverse momentum ($p_{\mathrm{T}}$) for 5-15% centrality in Pb-Pb collisions at $\sqrt{s_{\mathrm{NN}}}=2.76$~TeV.