Search results for "Polio"
showing 10 items of 90 documents
Booster vaccination after neonatal priming with acellular pertussis vaccine.
2010
After a birth dose of acellular pertussis (aP) and diphtheria (DT)aP-hepatitis B virus (HBV)-inactivated polio vaccine (IPV)/ Haemophilus influenza type b (Hib) at 2, 4, and 6 months, a booster dose of DTaP-HBV-IPV/Hib at 12 to 23 months induced strong anti-pertussis booster responses. Thus, neonatal aP priming did not lead to immune tolerance to pertussis antigens. However, it elicited bystander interference on HBV, Hib, and diphtheria responses.
Structural Insight into CVB3-VLP Non-Adjuvanted Vaccine
2020
Coxsackievirus B (CVB) enteroviruses are common pathogens that can cause acute and chronic myocarditis, dilated cardiomyopathy, aseptic meningitis, and they are hypothesized to be a causal factor in type 1 diabetes. The licensed enterovirus vaccines and those currently in clinical development are traditional inactivated or live attenuated vaccines. Even though these vaccines work well in the prevention of enterovirus diseases, new vaccine technologies, like virus-like particles (VLPs), can offer important advantages in the manufacturing and epitope engineering. We have previously produced VLPs for CVB3 and CVB1 in insect cells. Here, we describe the production of CVB3-VLPs with enhanced pro…
Procesos de expolio y reutilización de la arquitectura pública romana en el territorio valenciano
2018
Se efectúa un análisis de los procesos de expolio y transformación de grandes conjuntos monumentales y edificios singulares, fundamentalmente para espectáculos, en las ciudades romanas ubicadas en el territorio que en la actualidad integra el País Valenciano. El foro, por su condición de locus celeberrimus en el paisaje urbano romano, constituye el mejor indicador del ritmo e intensidad con que esos espacios privilegiados, en unos casos, sucumbieron en un proceso de abandono generalizado, como en Lucentum (el Tossal de Manises, Alicante), mientras que en ciudades habitadas hasta nuestros días, como es Valencia, se asistió a una imparable transformación de su imagen hasta no quedar huella al…
Effect of poly(I).poly(C12U) (Ampligen) on enteric virus (rotavirus, poliovirus and Coxsackie B3 virus) infections
1994
The effects of poly(1)-poly(C 12 U) (Ampligen) on infections with enteric viruses (rotavirus, poliovirus and Coxsackie B3 virus) were studied in vitro. Ampligen exhibited antiviral activity against rotavirus, especially when treatment was performed prior to inoculation of the virus. It was partially effective against Coxsackie B3 virus, but not against poliovirus. It is suggested that the observed effects may be due to the production of interferon induced by Ampligen
Deletion and insertion mutants of HBsAg particles
1992
We have found previously that hybrid 22-nm HBsAg particles can be created by insertion of short antigenic sequences into the HBV major envelope protein [1]. We have now performed a detailed deletion mutagenesis of the S gene of HBV encoding HBsAg. Deletion of the 51 C-terminal amino acids including most of the third and all of the fourth hydrophobic domain of the S protein did not affect particle assembly and secretion. However, secretion of 22-nm particles was abolished by minor deletions in the N-terminal region. Insertion and deletion/substitution mutants carrying a poliovirus epitope at the N-terminus and the preSl region at the C-terminus have been characterized.
Halloysite nanotubes as polyolefin fillers
2015
Artykuł stanowi przegląd najnowszej literatury dotyczącej nanokompozytów poliolefinowych napełnianych nanorurkami haloizytowymi (HNT). Omówiono wpływ dodatku HNT na osnowę poliolefinową, ze szczególnym uwzględnieniem morfologii oraz właściwości mechanicznych nanokompozytów poliolefina/HNT. Modyfikowane HNT wykazywały wysoki stopień rozproszenia w osnowie poliolefinowej, dzięki czemu powodowały poprawę właściwości mechanicznych poliolefinowych nanokompozytów napełnianych nanorurkami haloizytowymi. Połączenie korzystnych właściwości poliolefin, ekonomicznych metod ich przetwórstwa oraz unikatowych w³aoeciwooeci HNT pozwoli na szersze rozpowszechnienie nanokompozytów wytworzonych z ich udziałe…
Spain and the international scientific conferences on polio, 1940s-1960s
2010
The development of international health from a historical point of view has undergone major advances in recent times and constitutes a substantial part of the current agenda for historians of medicine. Within this framework, and focussing on a specific case study (international responses to poliomyelitis outbreaks in the 20th century), we explore the main actions and achievements of agencies such as the WHO and other private and international scientific organizations. Furthermore, this paper seeks to identify the Spanish presence and absence in these activities, their causes and consequences.
Limitēta skābekļa apstākļos augušu rauga šūnu dehidratācija un daži biotehnoloģiski pielietojumi
2015
Darba mērķis bija salīdzināt žāvēšanas procesu aerobi un anaerobi kultivētiem raugiem, noskaidrot šo raugu iespējamās izmantošanas iespējas dažos biotehnoloģiskos procesos. Darbā izmantoti mikroorganismu celmi Saccharomyces cerevisiae 14 un Saccharomyces cerevisiae 77. Darbā apskatīti literatūras dati par S.cerevisiae rauga ģinti, rauga šūnas uzbūvi un metabolismu, raugu izmantošanu dažos biotehnoloģiskos procesos (hroma sorbcija, etanola fermentācija), anabiozi, dažām rauga šūnu izdzīvotības paaugstināšanas iespējām pēc dehidratācijas (inkubācija šķīdumos ar paaugstinātu osmotisko spiedienu, siltumšoku). Tika apgūtas šādas darbā izmantotās metodes: S.cerevisiae celmu uzturēšana, sējmateriā…
Combination vaccines containing DTPa–Hib: impact of IPV and coadministration of CRM197 conjugates
2008
Vaccination with diphtheria-tetanus-acellular pertussis (DTPa)-Haemophilus influenzae type b (Hib) combinations generally elicits anti-polyribosyl-ribitol-phosphate (PRP) antibody concentrations of more than 0.15 microg/ml, a criterion that is linked to the protection of infants against Hib disease. In the UK, vaccination with DTPa3-Hib elicited atypically low anti-PRP antibody levels and was associated with breakthrough Hib cases. While the absence of a toddler booster is considered to be a key factor explaining the lowered control of Hib disease, we propose that the coadministration of serogroup C Neisseria meningitidis conjugate vaccine (MenC)-CRM197, which coincided with the introductio…
Epidemiological and virological studies into the poliomyelitis in Valencia (1959-1969)
2009
Studies into the polio virus began in Valencia in 1959 with the work undertaken by the microbiologist Vicente Sanchis-Bayarri Vaillant. After his education at the Rochester University and at the Pasteur Institute, Sanchis-Bayarri Vaillant established a laboratory of cell cultures at the Faculty of Medicine in Valencia, where he developed a new diagnostic technique for the poliomyelitis virus. In addition, epidemiological studies were carried out both prior to and post the 1963 vaccination campaign, which proved that Sabin’s oral vaccine was both effective and safe for use.