Search results for "Positive"

Impact of BCR-ABL1 Transcript Type on Response, Treatment-Free Remission Rate and Survival in Chronic Myeloid Leukemia Patients Treated with Imatinib

2021

Chronic myeloid leukemia; BCR-ABL1 transcripts; Response to imatinib Leucemia mieloide crónica; Transcripciones de BCR-ABL1; Respuesta al imatinib Leucèmia mieloide crònica; Transcripcions BCR-ABL1; Resposta a imatinib The most frequent BCR-ABL1-p210 transcripts in chronic myeloid leukemia (CML) are e14a2 and e13a2. Imatinib (IM) is the most common first-line tyrosine–kinase inhibitor (TKI) used to treat CML. Some studies suggest that BCR-ABL1 transcript types confer different responses to IM. The objective of this study was to correlate the expression of e14a2 or e13a2 to clinical characteristics, cumulative cytogenetic and molecular responses to IM, acquisition of deep molecular response …

High flow nasal therapy in perioperative medicine: from operating room to general ward

2018

Abstract Background High flow nasal therapy (HFNT) is a technique in which humidified and heated gas is delivered to the airways through the nose via small nasal prongs at flows that are higher than the rates generally applied during conventional oxygen therapy. The delivered high flow rates combine mixtures of air and oxygen and enable different inspired oxygen fractions ranging from 0.21 to 1. HFNT is increasingly used in critically ill adult patients, especially hypoxemic patients in different clinical settings. Main body Noninvasive ventilation delivers positive pressure (end-expiratory and inspiratory pressures or continuous positive airway pressure) via different external interfaces. …

Preventing technostress through positive technology

2018

Over the past decade, the workplace has experienced significant changes as a result of Information and Communication Technologies (ICTs) and the subsequent digital transformation (Mcafee, 2006; Matt et al., 2015). Such technological, cultural, and organizational changes have redefined business models and competition. As evidenced by the shift from the Enterprise 1.0 to the Enterprise 2.0 business models, ICTs offer companies increased productivity and efficiency (Bilbao-Osorio et al., 2013). At the same time, introduction of ICTs can pose a threat to both a company and its employees through misuse, abuse, and overuse, resulting in technostress (Gaudioso et al., 2017). This emerging risk see…

Mixed reality for cross-cultural integration: using positive technology to share experiences and promote communication

2018

Good things never last: dampening positive emotions influences our optimism levels

2016

A pesar del creciente interés en la comprensión de las estrate-gias de regulación emocional (RE) de las emociones positivas y su relación con la salud mental, la relación entre los diferentes estilos de respuesta al afecto positivo y estilos cognitivos como el optimismo aún no se ha proba-do empíricamente. El objetivo del presente estudio fue evaluar el efecto de las estrategias para regular emociones positivas (evaluadas por el cuestiona-rio Response to Positive Affect -RPA) sobre el optimismo, y la posible media-ción del afecto positivo en esta relación. 250 participantes completaron el cuestionario RPA, medidas de optimismo y afecto positivo, y realizaron un procedimiento de inducción em…

Distance and coupling: analyzing the pressures of accounting change in a city

2008

PurposeThe purpose of this paper is to analyze the accounting performance measurement (PM) change process in a Finnish city.Design/methodology/approachInterpretive case study. Data consisted of 16 semi‐structured interviews. Analysis was based on institutional theory, particularly on “new institutional sociology” (NIS) studies.FindingsBudgeting and accounting PM became coupled into action when various intertwined (mostly institutional) pressures affecting change converged. Perceived crises were found to accelerate accounting change by deinstitutionalization, i.e. by breaking (drastically) existing routines and myths. Further, accounting rules and routines changed somewhat independently. Fur…

Victimization, loneliness, overt and relational violence at the school from a gender perspective

2015

This ex post facto study analyzes both the direct relationships between victimization and overt and relational violent behavior of students adolescents as the indirect relationships between these variables through the classroom environment, the loneliness, the nonconformist ideal reputation and transgression of social norms. The sample consisted of 1,795 adolescents (48% females) aged 11 to 18 years (M = 14.2, SD = 1.68). We used a structural equation model to analyze the effect of classroom environment and victimization in violent manifest and relational behavior. The results found that a direct positive relationship between victimization and relational violent behavior and a direct negati…

Dynamic regulation of CD8 T cell tolerance induction by liver sinusoidal endothelial cells.

2010

Abstract Cross-presentation of soluble Ag on MHC class I molecules to naive CD8 T cells by liver sinusoidal endothelial cells (LSECs) leads to induction of T cell tolerance that requires interaction between coinhibitory B7-H1 on LSECs and programmed cell death-1 on CD8 T cells. In this study, we investigate whether cross-presentation of high as well as low Ag concentrations allowed for LSEC-induced tolerance. Ag concentration directly correlated with the cross-presentation capacity of murine LSECs and thus strength of TCR stimulation. Although LSEC cross-presentation at low-Ag concentrations resulted in tolerance, they induced differentiation into effector T cells (CTL) at high-Ag concentra…

The impact of growth history and flagellation on the adhesion of variousListeria monocytogenesstrains to polystyrene

2009

International audience; The contribution of growth history and flagella to adhesion of Listeria monocytogenes was analysed. An in-frame deletion on the flagellin encoding gene (flaA) was performed in L. monocytogenes EGD-e to compare its adhesion ability with the parental strain, after cultivation at various pH values and temperatures. The pH, as well as the temperature, affected the adhesion of L. monocytogenes EGD-e. In addition, the adhesion of L. monocytogenes EGD-e was reduced in energy-depressed cells. Conversely, the physicochemical bacterial surface characteristics affected by growth history did not influence the adhesion. Adhesion variations observed among environmental and clinica…

FIRST EPISODE PSYCHOTIC PATIENTS WITH A HISTORY OF FREQUENT CANNABIS USE EXPRESS MORE POSITIVE SYMPTOMS AT ILLNESS ONSET THAN THOSE WHO NEVER USED CA…

2018

Background: Robust evidence has demonstrated that cannabis use increases the risk to develop psychotic disorders. However, a limited number of studies have investigated if and how cannabis use influences psychopathology profiles at first episode psychosis (FEP). Based on the evidence that dopamine dysfunction contributes to explain positive symptoms in psychosis, and that the main cannabis’ psychoactive component, Δ9-Tetrahydrocannabinol (THC), modulates the dopamine system, we hypothesise that: 1) positive symptoms at FEP are more common among psychotic patients who used cannabis compared with never users; 2) this association is a dose-response relationship. Methods: We analyzed a sample o…