Search results for "Poster"
showing 10 items of 679 documents
Transgenic tools for proteomic analysis of ciliary transport
2015
Vision begins as photons are captured by photoreceptor cilia and light is converted into electrical signals that are then sent to the brain. As the photoreceptor cilium is not able to make its own proteins, all polypeptides needed for converting photons into electrical signals are synthetized in the cell body. How these molecules move from the cell body to cilia is still unclear. Opsin is one of the best-characterized transmembrane proteins. Our goal is to understand the mechanism of opsin transport into photoreceptor cilia. In this project, we use a combination of genetic and proteomic approaches in the zebrafish model. As the first step, we are constructing a transgenic line that expresse…
Identification of novel interaction partners for Vlgr1b/GPR98 - a key component of the periciliary Usher syndrome protein network in photoreceptor ce…
2012
The human Usher syndrome (USH) is the most common form of combined hereditary deaf-blindness. Three clinical subtypes (USH1-3) are differentiated based on severity, age of onset and progression of the symptoms. Mutations in the GPR98 gene encoding the USH2C protein Vlgr1b or GPR98 cause USH2, the most common form of USH. The G-protein coupled receptor Vlgr1b was previously identified as a component of the periciliary USH protein network, crucial for ciliary cargo transport in photoreceptors. Nonetheless, the exact role of Vlgr1b in this and other cellular processes remains to be elucidated. To learn more about its involvement in cellular functions we searched for novel interaction partners …
Calculation and inversion of two-dimensional gravity in the vicinity of Lake Tuz, Turkey
2000
Abstract An example of gravity inversion and interpretation is presented which demonstrates how a priori information can be used to derive reliable, though complex models. In this case, the geometry of the studied model profile has been constructed on the basis of seismic and geological data. The densities used in the forward calculations were obtained from laboratory measurements of drill cores, from density-velocity relationships, and from Nettleton’s method of fitting gravity and topography. In the seismic section 21 ‘formations’ are distinguished leading to a very complex gravity model. What is called ‘formations’ here, are two-dimensional bodies which are distinguished from each other …
Medium term effects of a ketogenic diet and a Mediterranean diet on resting energy expenditure and respiratory ratio
2012
Background Very low carbohydrate ketogenic type diets (VLCKD) have been shown to be more effective for body weight reduction and fat loss compared to balanced or low-calorie Mediterranean diets, at least in the short-medium term [1,2], although the underlying mechanisms of its efficacy are still not well understood. Despite being a diet in widespread use there are few data available regarding effects on respiratory ratio (RR) [3,4] and resting energy expenditure (REE) and, more specifically, there are no reports about the effects on RR following a return to a non ketogenic diet. The aim of this study was to compare the effects of a 20 day ketogenic Mediterranean diet with phytoextracts (KEM…
Spatules de Thierry ou forceps : comparaison des morbidités materno-fœtales
2016
Resume Objectif Comparer la morbidite materno-fœtale immediate lors d’une l’extraction par forceps ou par spatules de Thierry. Methodes Etude retrospective, descriptive, monocentrique de 2006 a 2012. Les extractions etaient realisees par spatules ou forceps pour defaut de progression du mobile fœtale, sur singleton, en presentation cephalique, a terme, sans anomalies du rythme cardiaque fœtal et sans pathologie gravidique associee. Resultats Notre serie comprenait 65 extractions par spatules contre 77 par forceps. Nos populations etaient comparables. Au niveau maternel, on retrouvait davantage de perinees intacts (5,19 % versus 15,38 %, p = 0,04), autant de dechirures vaginales et moins de …
Remote Photoplethysmography measurement using constrained ICA
2017
Remote Photoplethysmography (rPPG) is a technique that consists in estimating physiological parameters such as heart rate from live or recorded video sequences taken by conventional camera or even webcams. This technique is increasingly used in many application fields thanks to its simplicity and affordability. The basic idea is that the arterial blood flow shows regularity due to the heartbeat. This regularity is manifested by very small periodic variations in the color of the skin, which can be isolated and quantified by signal and image processing methods. In this context, Independent Component Analysis (ICA) is largely used to separate the signal due to arterial flow from signals from o…
Epidural hematoma after cochlear implantation in a 2.5-year-old boy.
2005
OBJECTIVE Report a case of an epidural hematoma after cochlear implantation in a 2.5-year-old boy, the diagnostic and therapeutical emergency management, as well as the postinterventional course and rehabilitation of the child. STUDY DESIGN Retrospective case review. PATIENT Two and a half-year-old boy, suffering from early onset, profound sensorineural hearing loss had been diagnosed at an age of 1.5 years, which had been more severe on the right side initially, but had progressed to bilateral deafness. INTERVENTION AND COMPLICATION: Cochlear implantation on the left side, followed up by an extensive epidural hematoma, causing intracranial compression with a midline shift of 15 mm to the r…
Computer-aided detection of cerebral microbleeds in susceptibility-weighted imaging.
2014
Susceptibility-weighted imaging (SWI) is recognized as the preferred MRI technique for visualizing cerebral vasculature and related pathologies such as cerebral microbleeds (CMBs). Manual identification of CMBs is time-consuming, has limited reliability and reproducibility, and is prone to misinterpretation. In this paper, a novel computer-aided microbleed detection technique based on machine learning is presented: First, spherical-like objects (potential CMB candidates) with their corresponding bounding boxes were detected using a novel multi-scale Laplacian of Gaussian technique. A set of robust 3-dimensional Radon- and Hessian-based shape descriptors within each bounding box were then ex…
Early calcification patterns of the iliac arteries and their relation to the arterial structure
1972
Gross calcifications of the common iliac and internal iliac arteries represent a common finding in newborn children and infants. In both arteries, the calcific deposits regularly appear in certain areas of the arterial luminal surface only, whereas the other parts of the arterial wall remain free of gross lesions even in cases with a pronounced calcification. In the common iliac artery, the lateral wall of the vessel and the adjacent sectors of the anterior and posterior wall represent the predilection site of calcific deposits. In the internal iliac artery, the gross calcifications have been regularly demonstrated in the dorso-medial wall. The predominant localisation of the calcification …
Sequential Monte Carlo Methods in Random Intercept Models for Longitudinal Data
2017
Longitudinal modelling is common in the field of Biostatistical research. In some studies, it becomes mandatory to update posterior distributions based on new data in order to perform inferential process on-line. In such situations, the use of posterior distribution as the prior distribution in the new application of the Bayes’ theorem is sensible. However, the analytic form of the posterior distribution is not always available and we only have an approximated sample of it, thus making the process “not-so-easy”. Equivalent inferences could be obtained through a Bayesian inferential process based on the set that integrates the old and new data. Nevertheless, this is not always a real alterna…