Search results for "Pounds"

showing 10 items of 3374 documents

Selective, Sensitive, and Rapid Analysis with Lateral-Flow Assays Based on Antibody-Gated Dye-Delivery Systems: The Example of Triacetone Triperoxide

2013

[EN] Antibodygated MSNs that are loaded with a rhodamine dye and that can be used for the determination of the presence of peroxide-based explosive TATP with a lateral-flow fluorescence reader have been designed and prepared, thereby allowing for detection limits in the lower ppb range. The mechanism of the detection relies on a displacement of the antibody from the surface of the hybrid material because of highly affine antibody-TATP interactions, which release a much larger number of entrapped dye molecules from the pores than antibodies are displaced. The high selectivity of the antibody is retained in the gated material, thus allowing for a remarkable discrimination against H2O2. System…

ChemistryRhodaminesOrganic ChemistryQUIMICA INORGANICANanotechnologyGeneral ChemistrySilicon DioxideCatalysisAntibodiesMesoporous materialsFluorescencePeroxidesHeterocyclic Compounds 1-RingDrug Delivery SystemsQUIMICA ORGANICAModels ChemicalQUIMICA ANALITICANanoparticlesExplosivesDyes/pigmentsImmunoassaysFluorescent Dyes
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Mechanisms of Organic Coating on the Surface of a Poplar Biochar

2017

Background: Recent studies highlighted that biochar efficiency to improve soil fertility is enhanced after it is blended with fresh organic materials. It was suggested that organic coating of inner-porous biochar surfaces acts as a kind of “glue” for plant-nutrients, thereby allowing their slow release towards plant-roots and/or microorganisms. Objective: The aim of the present study is to improve the understanding of the nature of the interactions between fresh organic matter and a poplar biochar. Method: Two fluorinated organic models were used as target molecules in order to apply heteronuclear (i.e. 19F) fast field cycling (FFC) NMR relaxometry. Results: The results suggest that organic…

ChemistrySettore AGR/13 - Chimica AgrariaOrganic Chemistry04 agricultural and veterinary sciences010501 environmental sciencesengineering.material01 natural sciencesBiochar fast field cycling fluorine NMR fluorinated compounds organic coating pyrolysis biochar relaxometryAgronomyCoatingChemical engineeringBiochar040103 agronomy & agricultureengineering0401 agriculture forestry and fisheries0105 earth and related environmental sciencesCurrent Organic Chemistry
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Über die Synthese von o-Acylamino-β-dimethylaminopropiophenonen Mitt.: Aminomethylierung von 2-Nitro-5-methoxy-und 2-Nitro-5-benzyloxyacetophenon

1971

Der von Makino und Takahashi sowie Joh als 2-Nitro-5-methoxy-β-dimethylamino-propiophenon bezeichnete Korper wurde als 2-Nitro-5-methoxy-α-dimethylaminomethyl-acrylophenon identifiziert. Nach einer fruher beschriebenen Methode zur Darstellung von 2-Nitro-β-dimethylamino-propiophenon war es moglich, 2-Nitro-5-methoxy- und 2-Nitro-5-benzyloxy-acetophenon normal zu aminomethylieren. –Die Synthese von 2-Amino-5-methoxy-, 2-Amino-5-benzyloxy- und 2-Amino-5-hydroxy-β-dimethylamino-propiophenon sowie ihrer Acetylderivate wird beschrieben. Synthesis of o-Acylamino-β-dimethylamino-propiophenones The compound synthetized by Makino and Takahashi and by Joh described as 2-nitro-5-methoxy-β-dimethylamin…

ChemistryStereochemistryDrug Discoverypolycyclic compoundsPharmaceutical ScienceArchiv der Pharmazie
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Using theozymes for designing transition-state analogs for the intramolecular aldol reaction of δ-diketones

2001

Two theozymes for the intramolecular aldol reaction of δ-diketones have been studied using ab initio methods. The presence of both acid/base residues favors several steps of the aldol reaction. The appropriate positioning of these residues can accelerate one of two diastereromeric reaction pathways, the catalyzed aldol reaction being highly stereoselective. Analysis of the geometrical parameters, charge distribution, and the shape of molecular electrostatic potential for the corresponding acid/base catalyzed transition structure allows us to design adequate transition-state analogs to favor a reactive channel of this intramolecular aldol reaction. © 2001 John Wiley & Sons, Inc. Int J Quant …

ChemistryStereochemistryorganic chemicalsAb initioCondensed Matter PhysicsAtomic and Molecular Physics and OpticsCatalysisLewis acid catalysisAldol reactionTransition state analogAb initio quantum chemistry methodsIntramolecular forcepolycyclic compoundsStereoselectivityPhysical and Theoretical ChemistryInternational Journal of Quantum Chemistry
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Stereoselective synthesis of 2-amino-1-hydroxy-3-phenylpropylphosphonic acid

1996

Abstract A highly stereoselective synthesis of 2-amino-1-hydroxy-3-phenylpropylphosphonic acid was achieved by simple addition of diethyl phosphite to enantiomeric N-blocked phenylalaninals. These compouds exhibit significant herbicidal activity.

Chemistryorganic chemicalsOrganic ChemistryClinical BiochemistryDrug DiscoveryPharmaceutical ScienceMolecular MedicineOrganic chemistryheterocyclic compoundsStereoselectivityEnantiomerMolecular BiologyBiochemistryBioorganic & Medicinal Chemistry Letters : a tetrahedron publication for the rapid dissemination of preliminary communication and all aspects of bioorganic chemistry, medicinal chemistry and related disciplines
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Enantioselective Synthesis of Unsymmetrical Benzoins from (S)-Mandelic Acid Enolate and Aromatic Aldehydes.

2004

The reaction of the lithium enolate of the 1,3-dioxolan-4-one derived from optically active (S)-mandelic acid and pivalaldehyde with aromatic aldehydes proceeds readily to give the corresponding aldol products in good yields and diastereoselectivities. Subsequent hydroxyl protection, basic hydrolysis of the dioxolanone, oxidative decarboxylation of the α-hydroxyacid moiety, and hydroxyl deprotection provides chiral unsymmetrical benzoins with high enantiomeric excesses.

Chemistryorganic chemicalsOrganic ChemistryEnantioselective synthesischemistry.chemical_elementGeneral MedicineOptically activeMandelic acidBiochemistrychemistry.chemical_compoundAldol reactionDrug Discoverypolycyclic compoundsOrganic chemistryMoietyLithiumEnantiomerOxidative decarboxylationChemInform
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ChemInform Abstract: Stereoselective Synthesis of 2-Amino-1-hydroxy-3- phenylpropylphosphonic Acid.

2010

Abstract A highly stereoselective synthesis of 2-amino-1-hydroxy-3-phenylpropylphosphonic acid was achieved by simple addition of diethyl phosphite to enantiomeric N-blocked phenylalaninals. These compouds exhibit significant herbicidal activity.

Chemistryorganic chemicalsOrganic chemistryheterocyclic compoundsStereoselectivityGeneral MedicineEnantiomerChemInform
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Cationic mono- and bi-nuclear iron complexes as Lewis acid catalysts in Mukaiyama reactions

1992

Organometallic Lewis acids derived from photolysis of mono- and bi-nuclear cationic iron carbonyl complexes function as excellent catalysts for the Mukaiyama aldol reaction.

Chemistryorganic chemicalseducationPhotodissociationCationic polymerizationhumanitiesCatalysisLewis acid catalysisAcid catalysisAldol reactionPolymer chemistrypolycyclic compoundsMolecular MedicineOrganic chemistryLewis acids and basesJournal of the Chemical Society, Chemical Communications
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The fungal lactone oxacyclododecindione is a potential new therapeutic substance in the treatment of lupus-associated kidney disease.

2013

Recently oxacyclododecindione (Oxa), a macrocyclic lactone isolated from the imperfect fungus Exserohilum rostratum, has been described as a potent transcription inhibitor of inducible proinflammatory and profibrotic genes in cell culture models. As kidney disease in systemic lupus erythematosus is characterized by aberrant expression of inflammatory mediators and infiltration of immune cells, we investigated the effect of Oxa in MRL-Fas(lpr) mice, a model of systemic lupus erythematosus. These mice develop a spontaneous T-cell and macrophage-dependent autoimmune disease including severe glomerulonephritis that shares features with human lupus. Comparable to the results of in vitro models, …

ChemokineMice Inbred MRL lprMacrocyclic CompoundsAnti-Inflammatory AgentsProtein Array AnalysisGene ExpressionInflammationChemokine CXCL9Proinflammatory cytokineInterferon-gammaMiceImmune systemmedicineAnimalsCalgranulin ARNA MessengerChemokine CCL4Chemokine CCL5Chemokine CCL2Autoimmune diseaseSystemic lupus erythematosusbiologyInterleukin-6Tumor Necrosis Factor-alphaGlomerulonephritismedicine.diseaseLupus NephritisChemokine CXCL12Disease Models AnimalNephrologyImmunologybiology.proteinCytokinesFemaleOsteopontinmedicine.symptomKidney diseaseKidney international
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Synthesis of novel polypyridylcarbonylpyridines from triazolopyridines. Building blocks in supramolecular chemistry

2009

The synthesis from triazolopyridines 1, of novel triazolopyridylcarbonylpyridylcarbonyltriazolopyridines (TPyCOPyCOTPy) (tpcpctp) 7, and polypyridylcarbonylpyridines (pPyCOPy) (ppcp) 14, building blocks in supramolecular chemistry, is described. These compounds are interesting polynitrogenated ligands as potential molecular sensors, new magnetic materials, single molecular magnets, or in the emerging science of nanomaterials. Abarca Gonzalez, Belen, Belen.Abarca@uv.es ; Ballesteros Campos, Rafael, Rafael.Ballesteros@uv.es ; Chadlaoui, Mimoun, michad@alumni.uv.es

ChemosensorsMaterials scienceMolecular magnetsUNESCO::QUÍMICATriazolopyridines ; Pyridylcarbonylpyridines ; Polynitrogenated ligands ; Nanomaterials supramolecular receptors ; Chemosensors ; Clusters ; Fluorescent compounds:QUÍMICA::Química orgánica [UNESCO]Organic ChemistrySupramolecular chemistryFluorescent compoundsNanotechnologyPolynitrogenated ligands:QUÍMICA [UNESCO]Combinatorial chemistryNanomaterialslcsh:QD241-441Clusterslcsh:Organic chemistryNanomaterials supramolecular receptorsTriazolopyridinesUNESCO::QUÍMICA::Química orgánicaPyridylcarbonylpyridinesArkivoc
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