Search results for "PreP"
showing 10 items of 1334 documents
Physics, Techniques and Review of Neuroradiological Applications of Diffusion Kurtosis Imaging (DKI)
2016
In recent years many papers about diagnostic applications of diffusion tensor imaging (DTI) have been published. This is because DTI allows to evaluate in vivo and in a non-invasive way the process of diffusion of water molecules in biological tissues. However, the simplified description of the diffusion process assumed in DTI does not permit to completely map the complex underlying cellular components and structures, which hinder and restrict the diffusion of water molecules. These limitations can be partially overcome by means of diffusion kurtosis imaging (DKI). The aim of this paper is the description of the theory of DKI, a new topic of growing interest in radiology. DKI is a higher or…
Induction of Human P-Glycoprotein in Caco-2 cells: Development of a Highly Sensitive Assay System for P-Glycoprotein-Mediated Drug Transport
2006
The aim of this work is to develop a highly sensitive assay system for P-gp-mediated transport by using two methods, induction of P-gp and short-term culture of Caco-2 cells. To induce P-gp in Caco-2 cells, cells were cultured in vinblastine-containing medium. The mRNA level of P-gp was approximately 7-fold higher in Caco-2 cells cultured with vinblastine (P-gp-induced Caco-2 cells) than in control cells. Western blot analysis showed a significant increase in P-gp expression. After cell differentiation, the mRNA level of P-gp was downregulated, however, P-gp-induced Caco-2 cells still possessed a 5.6-fold higher mRNA level of P-gp compared to control cells. Polarized transport of substrate …
Decision Support for Disaster Risk Management: Integrating Vulnerabilities into Early-Warning Systems
2014
International audience; Despite the potential of new technologies and the improvements of early-warning systems since the 2004 Tsunami, damage and harm caused by disasters do not stop to increase. There is a clear need for better integrating the fragmented landscape of researchers and practitioners working on different aspects of decision support for disaster risk reduction and response. To demonstrate and discuss the advantages of integrated systems, we will focus in this paper on vulnerabilities and early-warning systems. While vulnerabilities are mostly used to allocate risk management resources (preparedness), early-warning systems are designed to initiate the response phase. Indicator …
Continuity and discontinuity in the semantics of the Latin preposition per: a cognitive hypothesis
2011
Abstract We propose a description of the semantic network of the Latin prepositional phrase per ‘through’ + Accusative in the early stage of this language. Drawing upon the insights of Cognitive Grammar, we analyze the role of the schematic import in the spread from basic to abstract meanings. Finally, we draw a map of the polysemous network of per, showing that the continuity of the different, but consistently linked, meanings does not necessarily imply the unidirectionality of the concrete-to-abstract shifts.
An extension of the Burrows-Wheeler Transform and applications to sequence comparison and data compression
2005
We introduce a generalization of the Burrows-Wheeler Transform (BWT) that can be applied to a multiset of words. The extended transformation, denoted by E, is reversible, but, differently from BWT, it is also surjective. The E transformation allows to give a definition of distance between two sequences, that we apply here to the problem of the whole mitochondrial genome phylogeny. Moreover we give some consideration about compressing a set of words by using the E transformation as preprocessing.
Latvijas veselības aprūpes institūciju un personāla gatavība katastrofu pārvaldīšanā
2017
Ievads: Pēdējo desmit gadu laikā pasaulē visu veidu katastrofu skaits ir ievērojami palielinājies, kā arī ievērojami ir pieaudzis cietušo cilvēku skaits. Līdz ar to slimnīcām un ārstiem jābūt gataviem risināt ārkārtas situācijas. Šis pētījums novērtē katastrofu pārvaldības sagatavotības līmeni Latvijas veselības aprūpes iestādēs un ārstu vidū. Materiāli un metodes: Materiāli tika apkopoti laika posmā no 2016. gada oktobra līdz 2017. gada februārim. 21 Latvijas slimnīcu administrācijai vai neatliekamās palīdzības vadītājiem tika dota pielāgota aptauja - Slimnīcas ārkārtas situāciju gatavības kontrollapa (Pasaules Veselības organizācijas Eiropas Reģionālā biroja, 2011), kas ietver četras galv…
Uso de antagonistas de la hormona liberadora de gonadotrofinas (GnRH) en la preparación endometrial de las receptoras de ovocitos
2015
INTRODUCCIÓN: La donación de ovocitos está bien establecida como técnica de reproducción asistida y ofrece la oportunidad única de tratar a mujeres con diferentes entidades clínicas, tanto con función ovárica como sin ella. En las pacientes con función ovárica conservada, se utilizan análogos de la GnRH (a-GnRH) para provocar una supresión hipofisaria, lo que permite conseguir una sincronización entre la donante y la receptora, evitando picos ovulatorios espontáneos que abrirían la ventana de implantación de la receptora en asincronía con la donante. OBJETIVO: El objetivo principal del estudio fue comparar los resultados obtenidos con el empleo de antagonistas de la GnRH (ant-GnRH) en la si…
Searching for Syntax in the Early Medieval Commentaries on Donatus
2023
This study aims at contributing to the reconstruction of the metalanguage and the specific terminology used by grammarians with reference to the reflection on syntax, as it emerges from the analysis of Late Antiquity and Early Middle Ages grammar texts. The study focuses on the description of prepositions within the commentaries on Donatus’s Artes. Despite the overall lack of a systematic treatment of syntax within the Greek-Latin grammatical tradition, the description of specific partes orationis, e.g. praepositio, shows actually traces of a certain reflection on syntax. The metaterminology used by grammarians to describe the mutual relation between linguistic elements seems to go even bey…
Direct injection of physiological fluids in micellar liquid chromatography
2000
Abstract Micellar liquid chromatography (MLC), which uses mobile phases of surfactants above the critical micellar concentration, provides a solution to the direct injection of physiological samples by solubilizing the protein components, and coating the analytical column with surfactant monomers to avoid clogging. A review showing the advantages and limitations of this technique over other chromatographic techniques used in drug analysis, working protocols, and examples of application is presented. The possibility of direct sample introduction simplifies and greatly expedites the treatments with reduced cost, improving the accuracy of the procedures. Surfactant monomers and micelles appear…
Intestinal drug efflux: formulation and food effects
2001
The intestine, primarily regarded as an absorptive organ, is also prepared for the elimination of certain organic acids, bases and neutral compounds depending on their affinity to intestinal carrier systems. Several of the transport systems known to mediate efflux in the major clearing organs--liver and kidney--are also expressed in the intestine. Examples of secretory transporters in the intestine are P-glycoprotein, members of the multidrug resistance associated protein family, breast cancer resistance protein, organic cation transporters and members of the organic anion polypeptide family. In this communication, the P-glycoprotein mediated intestinal secretion of talinolol, a model compo…