Search results for "Precision"
showing 10 items of 448 documents
Measurement of top-quark polarisation observables and a search for dark matter in single-top-quark production with the ATLAS detector at the LHC
2022
Esta tesis presenta dos análisis diferentes basados en los datos resultantes de colisiones protón-protón a una energía en el centro de masas de 13 TeV recolectados con el detector ATLAS del LHC, correspondientes a una luminosidad integrada de 139 fb$^{-1}$. El primer análisis presenta una medida de secciones eficaces diferenciales normalizadas del canal de producción de quarks top en solitario $t$-channel, donde el quark top se desintegra leptónicamente, como función de los tres ángulos de polarización del leptón para eventos con quarks top y quarks antitop tanto separadamente como de forma inclusiva. Estos observables son particularmente sensibles a efectos de nueva física en el vértice $t…
Molecular markers and endometrial cancer
2022
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Novel Approaches for Glioblastoma Treatment: Focus on Tumor Heterogeneity, Treatment Resistance, and Computational Tools
2019
BACKGROUND: Glioblastoma (GBM) is a highly aggressive primary brain tumor. Currently, the suggested line of action is the surgical resection followed by radiotherapy and treatment with the adjuvant temozolomide (TMZ), a DNA alkylating agent. However, the ability of tumor cells to deeply infiltrate the surrounding tissue makes complete resection quite impossible, and in consequence, the probability of tumor recurrence is high, and the prognosis is not positive. GBM is highly heterogeneous and adapts to treatment in most individuals. Nevertheless, these mechanisms of adaption are unknown. RECENT FINDINGS: In this review, we will discuss the recent discoveries in molecular and cellular heterog…
Endometrial Receptivity Analysis (ERA): data versus opinions
2021
Abstract This article summarises and contextualises the accumulated basic and clinical data on the ERA test and addresses specific comments and opinions presented by the opponent as part of an invited debate. Progress in medicine depends on new technologies and concepts that translate to practice to solve long-standing problems. In a key example, combining RNA sequencing data (transcriptomics) with artificial intelligence (AI) led to a clinical revolution in personalising disease diagnosis and fostered the concept of precision medicine. The reproductive field is no exception. Translation of endometrial transcriptomics to the clinic yielded an objective definition of the limited time period …
Three beta-decaying states in 128In and 130In resolved for the first time using Penning-trap techniques
2020
Isomeric states in 128In and 130In have been studied with the JYFLTRAP Penning trap at the IGISOL facility. By employing state-of-the-art ion manipulation techniques, three different beta-decaying states in 128In and 130In have been separated and their masses measured. JYFLTRAP was also used to select the ions of interest for identification at a post-trap decay spectroscopy station. A new beta-decaying high-spin isomer feeding the isomer in 128Sn has been discovered in 128In at 1797.6(20) keV. Shell-model calculations employing a CD-Bonn potential re-normalized with the perturbative G-matrix approach suggest this new isomer to be a 16⁺ spin-trap isomer. In 130In, the lowest-lying (10⁻) isom…
ETP/GDOP Behavior Study for N-Sensors Arrays ina Multilateration Radar System
2009
In this paper, we evaluated the ETP (Expected Theoretical Precision) and GDOP (Geometric Dilution Of Precision) enhancement related to the number of sensors in a Multilateration radar system. An introduction about the principles of the Multilateration radar system basis operation is described, then, the formulation for evaluation the ETP/GDOP of the 3D positioning is shown. We observed that the ETP and GDOP enhance with the increase of the number of sensors. A substantial improvement was obtained until nine sensors but, for more sensors that improvement is reduced. Results for a 75km×75km area are shown, including LAM (Local Area Multilateration) and WAM (Wide Area Multilateration) settings…
Towards precision oncology for HER2 blockade in gastroesophageal adenocarcinoma
2019
Gastroesophageal adenocarcinoma (GEA) represents a very heterogeneous disease and patients in advanced stages have a very poor prognosis. Although several molecular classifications have been proposed, precision medicine for HER2-amplified GEA patients still represents a challenge. Despite improvement in clinical outcomes obtained by adding trastuzumab to first-line platinum-based chemotherapy, no other anti-HER2 agents used first-line or beyond progression have demonstrated any benefit. Several factors contribute to this failure. Among them, variable HER2 amplification assessment, tumour heterogeneity, molecular mechanisms of resistance and microenvironmental factors could limit the effecti…
Precision Medicine to Treat Advanced Gastroesophageal Adenocarcinoma: A Work in Progress
2020
Gastroesophageal adenocarcinoma (GEA) represents a heterogeneous disease and, when diagnosed as locally advanced or metastatic, it is characterized by poor prognosis. During the last few years, several molecular classifications have been proposed to try to personalize treatment for those patients diagnosed with advanced disease. Nevertheless, despite the great effort, precision medicine is still far from being a reality. The improvement in the molecular analysis due to the application of high throughput technologies based on DNA and RNA sequencing has opened a novel scenario leading to the personalization of treatment. The possibility to target epidermal growth factor receptor (HER)2, Claud…
Nanoseconds Timing System Based on IEEE 1588 FPGA Implementation
2019
Clock synchronization procedures are mandatory in most physical experiments where event fragments are readout by spatially dislocated sensors and must be glued together to reconstruct key parameters (e.g. energy, interaction vertex etc.) of the process under investigation. These distributed data readout topologies rely on an accurate time information available at the frontend, where raw data are acquired and tagged with a precise timestamp prior to data buffering and central data collecting. This makes the network complexity and latency, between frontend and backend electronics, negligible within upper bounds imposed by the frontend data buffer capability. The proposed research work describ…
Next-generation sequencing: big data meets high performance computing
2017
The progress of next-generation sequencing has a major impact on medical and genomic research. This high-throughput technology can now produce billions of short DNA or RNA fragments in excess of a few terabytes of data in a single run. This leads to massive datasets used by a wide range of applications including personalized cancer treatment and precision medicine. In addition to the hugely increased throughput, the cost of using high-throughput technologies has been dramatically decreasing. A low sequencing cost of around US$1000 per genome has now rendered large population-scale projects feasible. However, to make effective use of the produced data, the design of big data algorithms and t…