Search results for "Precision"
showing 10 items of 448 documents
Precision Oliviculture: Research Topics, Challenges, and Opportunities—A Review
2022
Since the beginning of the 21st century, there has been an increase in the agricultural area devoted to olive growing and in the consumption of extra virgin olive oil (EVOO). The continuous change in cultivation techniques implemented poses new challenges to ensure environmental and economic sustainability. In this context, precision oliviculture (PO) is having an increasing scientific interest and impact on the sector. Its implementation depends on various technological developments: sensors for local and remote crop monitoring, global navigation satellite system (GNSS), equipment and machinery to perform site-specific management through variable rate application (VRA), implementation of g…
Targeting Cancer Chemotherapy Resistance by Precision Medicine-Driven Nanoparticle-Formulated Cisplatin.
2021
Therapy resistance is the major cause of cancer death. As patients respond heterogeneously, precision/personalized medicine needs to be considered, including the application of nanoparticles (NPs). The success of therapeutic NPs requires to first identify clinically relevant resistance mechanisms and to define key players, followed by a rational design of biocompatible NPs capable to target resistance. Consequently, we employed a tiered experimental pipeline fromiin silico/ito analytical andiin vitro/ito overcome cisplatin resistance. First, we generated cisplatin-resistant cancer cells and used next-generation sequencing together with CRISPR/Cas9 knockout technology to identify the ion cha…
Epigenetic biomarkers: Current strategies and future challenges for their use in the clinical laboratory
2017
Epigenetic modifications and regulators represent potential molecular elements which control relevant physiological and pathological features, thereby contributing to the natural history of human disease. These epigenetic modulators can be employed as disease biomarkers, since they show several advantages and provide information about gene function, thus explaining differences among patient endophenotypes. In addition, epigenetic biomarkers can incorporate information regarding the effects of the environment and lifestyle on health and disease, and monitor the effect of applied therapies. Technologies used to analyze these epigenetic biomarkers are constantly improving, becoming much easier…
Pro-Inflammatory Genetic Markers of Atherosclerosis
2013
Atherosclerosis (AS) is a chronic, progressive, multifactorial disease mostly affecting large and medium-sized elastic and muscular arteries. It has formerly been considered a bland lipid storage disease. Currently, multiple independent pathways of evidence suggest this pathological condition is a peculiar form of inflammation, triggered by cholesterol-rich lipoproteins and influenced both by environmental and genetic factors. The Human Genome Project opened up the opportunity to dissect complex human traits and to understand basic pathways of multifactorial diseases such as AS. Population-based association studies have emerged as powerful tools for examining genes with a role in common mul…
The role of telomeres in predicting individual radiosensitivity of patients with cancer in the era of personalized radiotherapy.
2014
Radiotherapy plays a key role in cancer treatments, but tumor cell death differs from one tumor to another. The response of patients to radiotherapy varies considerably and adverse side effects are difficult to prevent. The mechanisms involved in the heterogeneity of this response are not well understood. In order to enhance the efficacy and safety of radiotherapy, it is important to identify subpopulations most at risk of developing a late adverse response to radiotherapy. Telomeres are composed of multiple repeats of a unique sequence of nucleotides forming a TTAGGG pattern. They protect chromosomes from end-to-end fusion and maintain genomic stability. Telomeres have been shown to be ext…
openSNP–A Crowdsourced Web Resource for Personal Genomics
2014
Genome-Wide Association Studies are widely used to correlate phenotypic traits with genetic variants. These studies usually compare the genetic variation between two groups to single out certain Single Nucleotide Polymorphisms (SNPs) that are linked to a phenotypic variation in one of the groups. However, it is necessary to have a large enough sample size to find statistically significant correlations. Direct-To-Consumer (DTC) genetic testing can supply additional data: DTC-companies offer the analysis of a large amount of SNPs for an individual at low cost without the need to consult a physician or geneticist. Over 100,000 people have already been genotyped through Direct-To-Consumer genet…
A realist review to understand the efficacy and outcomes of interventions designed to minimise, reverse or prevent the progression of frailty.
2018
Interventions to minimise, reverse or prevent the progression of frailty in older adults represent a potentially viable route to improving quality of life and care needs in older adults. Intervention methods used across European Innovation Partnership on Active and Healthy Ageing collaborators were analysed, along with findings from literature reviews to determine 'what works for whom in what circumstances'. A realist review of FOCUS study literature reviews, 'real-world' studies and grey literature was conducted according to RAMESES (Realist and Meta-narrative Evidence Synthesis: Evolving Standards), and used to populate a framework analysis of theories of why frailty interventions worked,…
NUTRITION AND CANCER
1969
The last decades have seen the identification of a number of drugs targeting oncogene pathways, therefore contributing to moving the cancer therapy field toward precision medicine. However, existing and acquired resistance to targeted therapies represent major obstacles against their long-term effectiveness. In fact, the initial efficacy of targeted therapies is often limited to a portion of the patient population and is frequently followed by the acquisition of drug-resistant disease.
Precision medicine in breast cancer: reality or utopia?
2017
International audience; Many cancers, including breast cancer, have demonstrated prognosis and support advantages thanks to the discovery of targeted therapies. The advent of these new approaches marked the rise of precision medicine, which leads to improve the diagnosis, prognosis and treatment of cancer. Precision medicine takes into account the molecular and biological specificities of the patient and their tumors that will influence the treatment determined by physicians. This new era of medicine is accessible through molecular genetics platforms, the development of high-speed sequencers and means of analysis of these data. Despite the spectacular results in the treatment of cancers inc…
Numerical evaluation of iterated integrals related to elliptic Feynman integrals
2021
We report on an implementation within GiNaC to evaluate iterated integrals related to elliptic Feynman integrals numerically to arbitrary precision within the region of convergence of the series expansion of the integrand. The implementation includes iterated integrals of modular forms as well as iterated integrals involving the Kronecker coefficient functions $g^{(k)}(z,\tau)$. For the Kronecker coefficient functions iterated integrals in $d\tau$ and $dz$ are implemented. This includes elliptic multiple polylogarithms.