Search results for "Precondition"
showing 10 items of 55 documents
Short-term ischemia usually used for ischemic preconditioning causes loss of dendritic integrity after long-term survival in the gerbil hippocampus
2006
Ischemic preconditioning has been established as a powerful experimental neuroprotective strategy, both after global and focal cerebral ischemia. Little is known, however, about the structural and functional long-term outcome. Therefore, our present study was designed to check for potential subtle alterations in the hippocampus after long-term survival. Gerbils were subjected either to short-term ischemia of 2.5 min duration usually used for ischemic preconditioning (n=8) or to sham operation (n=6) and allowed to survive for 6 weeks. Hippocampi with neuronal densities comparable to those of sham-operated control animals were analyzed for dendritic marker proteins MAP2, MAP1B and synaptopodi…
A fast 3D dual boundary element method based on hierarchical matrices
2008
AbstractIn this paper a fast solver for three-dimensional BEM and DBEM is developed. The technique is based on the use of hierarchical matrices for the representation of the collocation matrix and uses a preconditioned GMRES for the solution of the algebraic system of equations. The preconditioner is built exploiting the hierarchical arithmetic and taking full advantage of the hierarchical format. Special algorithms are developed to deal with crack problems within the context of DBEM. The structure of DBEM matrices has been efficiently exploited and it has been demonstrated that, since the cracks form only small parts of the whole structure, the use of hierarchical matrices can be particula…
Professionalität und Postkonventionalität. Entwicklungstheoretische und soziologische Perspektiven auf professionalisiertes Handeln
2014
The purpose of the following article is to point out the essential role of postconventional moral judgement in professionalized action. By some examples I will demonstrate that it is the precondition of completed professionalization.
Zweizeitige Ösophagusresektion mit ischämischer Präkonditionierung des Schlauchmagens bei dekompensiertem Dolichomegaösophagus im Endstadium der Acha…
2008
Development of a megaesophagus with a sigmoid-shaped distal part in patients with achalasia--even in the course of successful myotomy with reduction of the resting pressure of the lower esophageal sphincter--is often the expression of an irreversible progression of the disease. Management of patients with end-stage achalasia and aperistaltic, dilated "burned-out" esophagus--with or without peptic stenosis--is a therapeutic challenge for gastroenterologists and surgeons. We report on a 37-year-old female patient with decompensated dolichomegaesophagus following multiple endoscopic and operative interventions at the lower and upper esophageal sphincters presenting with severe dysphagia and we…
Pharmacology of Ischemia-Reperfusion. Translational Research Considerations.
2016
Ischemia-reperfusion (IRI) is a complex physiopathological mechanism involving a large number of metabolic processes that can eventually lead to cell apoptosis and ultimately tissue necrosis. Treatment approaches intended to reduce or palliate the effects of IRI are varied, and are aimed basically at: inhibiting cell apoptosis and the complement system in the inflammatory process deriving from IRI, modulating calcium levels, maintaining mitochondrial membrane integrity, reducing the oxidative effects of IRI and levels of inflammatory cytokines, or minimizing the action of macrophages, neutrophils, and other cell types. This study involved an extensive, up-to-date review of the bibliography …
A fast dual boundary element method for 3D anisotropic crack problems
2009
In the present paper a fast solver for dual boundary element analysis of 3D anisotropic crack problems is formulated, implemented and tested. The fast solver is based on the use of hierarchical matrices for the representation of the collocation matrix. The admissible low rank blocks are computed by adaptive cross approximation (ACA). The performance of ACA against the accuracy of the adopted computational scheme for the evaluation of the anisotropic kernels is investigated, focusing on the balance between the kernel representation accuracy and the accuracy required for ACA. The system solution is computed by a preconditioned GMRES and the preconditioner is built exploiting the hierarchical …
Order optimal preconditioners for fully implicit Runge-Kutta schemes applied to the bidomain equations
2010
The partial differential equation part of the bidomain equations is discretized in time with fully implicit Runge–Kutta methods, and the resulting block systems are preconditioned with a block diagonal preconditioner. By studying the time-stepping operator in the proper Sobolev spaces, we show that the preconditioned systems have bounded condition numbers given that the Runge–Kutta scheme is A-stable and irreducible with an invertible coefficient matrix. A new proof of order optimality of the preconditioners for the one-leg discretization in time of the bidomain equations is also presented. The theoretical results are verified by numerical experiments. Additionally, the concept of weakly po…
Fictitious Domain Methods for the Numerical Solution of Two-Dimensional Scattering Problems
1998
Fictitious domain methods for the numerical solution of two-dimensional scattering problems are considered. The original exterior boundary value problem is approximated by truncating the unbounded domain and by imposing a nonreflecting boundary condition on the artificial boundary. First-order, second-order, and exact nonreflecting boundary conditions are tested on rectangular and circular boundaries. The finite element discretizations of the corresponding approximate boundary value problems are performed using locally fitted meshes, and the discrete equations are solved with fictitious domain methods. A special finite element method using nonmatching meshes is considered. This method uses …
Tridiagonal preconditioning for Poisson-like difference equations with flat grids: Application to incompressible atmospheric flow
2011
AbstractThe convergence of many iterative procedures, in particular that of the conjugate gradient method, strongly depends on the condition number of the linear system to be solved. In cases with a large condition number, therefore, preconditioning is often used to transform the system into an equivalent one, with a smaller condition number and therefore faster convergence. For Poisson-like difference equations with flat grids, the vertical part of the difference operator is dominant and tridiagonal and can be used for preconditioning. Such a procedure has been applied to incompressible atmospheric flows to preserve incompressibility, where a system of Poisson-like difference equations is …
Ischemic Preconditioning: Postischemic Structural Changes in the Brain
2008
Ischemic brain damage can be prevented or at least significantly reduced when there is a preceding brief ischemic period that does not exceed the threshold for tissue damage--a phenomenon termed "ischemic preconditioning" (ischemic PC). Experimental PC in rodents is now considered to be a model for transient ischemic attacks in humans, and there is increasing hope for translating the knowledge of underlying mechanisms in the animal models into the clinic to enhance endogenous neuroprotective mechanisms in patients with stroke. However, although PC was originally defined as a subtoxic stimulus without any morphologic damage, there is a growing body of evidence from studies using sensitive te…