Search results for "Premature"

Spontaneous labour at term is associated with fetal monocyte activation.

1999

SUMMARYThe aetiology of both term and preterm labour remains incompletely understood. Maternal infectious diseases as well as intra-uterine infections were shown to be a well established cause of uncontrollable preterm delivery, indicating that inflammatory reactions, regulated by maternal immunecompetent cells, are implicated in labour-promoting mechanisms. To investigate the possibility that the activation of the fetal immune system may be involved in labour induction, we examined cytokine production patterns of different cord blood cell populations obtained from neonates after spontaneous onset of normal term labour and vaginal delivery (n = 25), vaginal delivery but induced term labour …

Rescuing CFTR Protein Function: 1,3,4-oxadiazoles versus 1,2,4-oxadiazoles as readthrough inducing drugs

In Cystic fibrosis (CF) disease nonsense mutations in the CFTR gene cause the absence of the CFTR protein expression and a more severe form of the disease. About 10% of patient affected by CF show a nonsense mutation. A potential treatment of this alteration is to promote translational readthrough of premature termination codons (PTCs) by translational readthrough inducing drugs such as Ataluren (1). We reported a rationale for Ataluren promoted readthrough of PTCs by computational approach and GFP-reporter cell-based assay (2) and the observed enhancement of readthrough activity by some Ataluren derivatives (3, 4). In this context we aimed to compare the 1,2,4-oxadiazole core of Ataluren w…

OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF GENETIC DISEASES DUE TO NONSENSE MUTATIONS

2018

Are disclosed oxadiazole derivatives, their use as medicaments and in particular for the treatment of diseases associated with the presence of a nonsense mutation in the gene or a premature stop codon in the mRNA, pharmaceutical formulation comprising said oxadiazole derivatives and prodrug or mixture thereof and the methods for the preparation of said Oxadiazole derivatives.

Trasplante autólogo de médula ósea en ovario en mujeres con baja reserva ovárica y fallo ovárico precoz, para rejuvenecimiento del nicho ovárico y fa…

2020

Como consecuencia del retraso de la maternidad a causa de las tendencias sociales actuales, existe una disminución de la calidad y cantidad de ovocitos disponibles. Al problema fisiológico de la edad materna avanzada, se suman dos patologías, que asocian una baja reserva ovárica, en pacientes jóvenes: baja respuesta ovárica (del inglés, poor ovarian response, o POR), e insuficiencia ovárica prematura(del inglés, premature ovarian insufficiency o POI). Numerosos protocolos de estimulación ovárica han sido desarrollados, sin ser efectivos, siendo en la mayoría de los casos, la única opción para estas pacientes la donación de ovocitos/embriones. Varios trabajos de investigación han descrito la…

Stress induced premature liver senecence in adulthood after transient postnatal overfeeding in mice

2017

IF 2.043; International audience

Priekšlaicīgi dzimušu bērnu aprūpe stacionārā

2017

A N O T Ā C I J A Bakalaura darba tēma- Priekšlaicīgi dzimušu bērnu aprūpe stacionārā. Šī tēma ir aktuāla, jo ik gadu pasaulē nāk 15 miljoni bērni, no kuriem vismaz viens no 10 jaundzimušajiem piedzimst pirms laika. Savukārt Latvijā apmēram 1000 bērni piedzimst pirms noteiktajā laika. Tas ir 5,2 – 6,4% no kopējā bērnu skaita. Darbs tika veikts ar mērķi- Neiznēsātu bērnu un bērnu ar mazu svaru barošanas teorētisko un praktisko jautājumu pētīšana. Pētniecības uzdevumi ir izpētīt un apkopot zinātnisko literatūru par priekšlaikus dzimuša bērna barošanu. Analizēt Virdžīnijas Aveneles Hendersones (Virginia Avenel Henderson) māszinību teoriju balstītu vajadzībās. Analizēt Džona Boulbija teoriju ba…

Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells

2016

The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.

2021

Summary: Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, including Alzheimer’s disease (AD) and cancer. However, the mechanisms governing heterochromatin maintenance or its relaxation in pathological conditions remain poorly understood. Here we show that PIN1, the only phosphorylation-specific cis/trans prolyl isomerase, whose loss is associated with premature aging and AD, is essential to preserve heterochromatin. We demonstrate that this PIN1 function is conserved from Drosophila to humans and prevents…

Music therapy for improving premature infants' well-being and communication skills and enhancing mother-infant bonding : a case study

2016

Over the last few decades, mother-child attachment has received increasing attention in early intervention with prematurely born infants. In these early years, physical interactions constitute a crucial arena for early learning and brain development, and together with the strong emotional bonding between the mother and her infant, they build the foundation for later interaction relationships. Premature birth is a challenging experience for the mother-infant relationship and is always a risk factor in early interaction issues (long hospital stay, lack of physical closeness etc.). This case study aims to examine how music therapy can promote premature infant's well-being and encourage the cre…