Search results for "Presentation"

Characterization of lymphokine-mediated activation of macrophages for antigen presentation: studies with long-term cultured bone marrow-derived macro…

1984

In cultures of bone marrow (BM) supplemented with L cell-derived colony-stimulating factor a pure population of macrophages (M phi) differentiates, which can be further propagated with a doubling time of 3.8 days. "Young" BMM phi obtained on day 8 of culture were shown to act as antigen-presenting cells inducing the antigen-specific proliferation of the cloned T cell line ST2/K.9, whereas "old" M phi had lost this ability. However, at any time tested (up to 132 days) the presentation function of old BMM phi could be completely restored by pulsing the cells with lymphokines (LK). A duration of 11 hr for the LK-pulse was sufficient to trigger the M phi to exert an optimal presentation functio…

Neural Network Based Finite-Time Stabilization for Discrete-Time Markov Jump Nonlinear Systems with Time Delays

2013

Published version of an article in the journal: Abstract and Applied Analysis. Also available from the publisher at: http://dx.doi.org/10.1155/2013/359265 Open Access This paper deals with the finite-time stabilization problem for discrete-time Markov jump nonlinear systems with time delays and norm-bounded exogenous disturbance. The nonlinearities in different jump modes are parameterized by neural networks. Subsequently, a linear difference inclusion state space representation for a class of neural networks is established. Based on this, sufficient conditions are derived in terms of linear matrix inequalities to guarantee stochastic finite-time boundedness and stochastic finite-time stabi…

Tourism, language and globalization. A linguistic representation of St. Petersburg in Lonely Planet’s web site

Teaching foreign languages for specific purposes holds an importance that, at the present time, it is extended widely to the field of the tourism industry which uses natural languages to create a shared metalanguage. The languages used to describe a tourism destination are particularly interesting because they build up a tourism’s representation of the town in order to pilot the travellers’ choices. In this context, tour guides represent an interesting example because they offer to the learner-reader the possibility to explore the richness of a foreign language. This study proposes an analysis of St. Petersburg’s tourist guide contained in the Lonely Planet web magazine in the English langu…

Representation of Cruise: Cruisers and Noncruisers Cross Views

2014

The article demonstrates the interest in using social representations as a tool of analysis in the representation of cruise for cruisers and noncruisers. The main objective of this study is to identify and to compare social representations of cruise for these groups. The article is based on a review of the social representation theory literature. Using multiapproach methods focused on organizing principles, the results indicate some resemblance and many differences between both representations. Theoretical and managerial implications are discussed before the article concludes with limitations and directions for future research. Copyright © 2014 John Wiley & Sons, Ltd.

Staging the Impossible for Young Audiences: Preliminary Findings in a Research Project

2009

“You should not be able to notice that it is theatre for children!” says Suzanne Osten, Swedish theatre director. How is this view compatible with her statement that Theatre for Young Audiences (TYA) should always take the child's perspective? In this article I draw attention to Osten's motivation and ability to do what some reckon to be impossible, unheard of, and/or irresponsible. Staging taboos such as divorce, suicide, eating disorders, and schizophrenia for children has been something of a trademark for Osten. I will widen the focus beyond the thematic content, by analyzing how she gives this a formal expression: how theoretical, aesthetic, kinesthetic, and playful approaches challenge…

Immune Evasion Proteins Enhance Cytomegalovirus Latency in the Lungs

2009

ABSTRACT CD8 T cells control cytomegalovirus (CMV) infection in bone marrow transplantation recipients and persist in latently infected lungs as effector memory cells for continuous sensing of reactivated viral gene expression. Here we have addressed the question of whether viral immunoevasins, glycoproteins that specifically interfere with antigen presentation to CD8 T cells, have an impact on viral latency in the murine model. The data show that deletion of immunoevasin genes in murine CMV accelerates the clearance of productive infection during hematopoietic reconstitution and leads to a reduced latent viral genome load, reduced latency-associated viral transcription, and a lower inciden…

CD8 T Cells Control Cytomegalovirus Latency by Epitope-Specific Sensing of Transcriptional Reactivation

2006

ABSTRACT During murine cytomegalovirus (mCMV) latency in the lungs, most of the viral genomes are transcriptionally silent at the major immediate-early locus, but rare and stochastic episodes of desilencing lead to the expression of IE1 transcripts. This low-frequency but perpetual expression is accompanied by an activation of lung-resident effector-memory CD8 T cells specific for the antigenic peptide 168-YPHFMPTNL-176, which is derivedfrom the IE1 protein. These molecular and immunological findings were combined in the “silencing/desilencing and immune sensing hypothesis” of cytomegalovirus latency and reactivation. This hypothesis proposes that IE1 gene expression proceeds to cell surfac…

On the coupling between agent internal and agent/ environmental dynamics: Development of spatial representations in evolving autonomous robots

2008

In this article we describe how a population of evolving robots can autonomously develop forms of spatial representation which allow them to self-localize and to discriminate different locations of their environment by integrating sensory-motor information over time. The evolving robots also display a remarkable ability to generalize their skill in new environmental conditions that they have never experienced before. The analysis of the obtained results indicates that the evolved robots come up with simple and robust solutions that exploit quasi-periodic limit cycle dynamics emerging from the coupling between the robot/environmental dynamics and a robot's internal dynamics. More specifical…

From the Rhin-Rhône TGV to Rhin-Rhône "territory" : reticularity, mobility and territoriality in an intermediary space

2013

High-speed rail, destined to reduce the times-distances between major French and European cities, tends to push intermediary spaces into a rather unfavorable situation. Strongly polarized by the large urban centers that surround them, these intermediary areas are usually reduced to their sole status of transit areas. However, the Eastern tract, the first section of the LGV Rhine-Rhône project, through its regional dimension, constitutes a factor in the emergence of a territorialization process of the Rhine-Rhone area. Thus, the arrival of high speed rail is responsible for the creation of a network of cities that extends from Dijon to Basel. To address this territorial issue, a detailed ana…

Du TGV Rhin-Rhône au "Territoire" Rhin-Rhône : réticularité, mobilité et territorialité dans un espace intermédiaire

2013

High-speed rail, destined to reduce the times-distances between major French and European cities, tends to push intermediary spaces into a rather unfavorable situation. Strongly polarized by the large urban centers that surround them, these intermediary areas are usually reduced to their sole status of transit areas. However, the Eastern tract, the first section of the LGV Rhine-Rhône project, through its regional dimension, constitutes a factor in the emergence of a territorialization process of the Rhine-Rhone area. Thus, the arrival of high speed rail is responsible for the creation of a network of cities that extends from Dijon to Basel.To address this territorial issue, a detailed anal…