Search results for "Presentation"
showing 10 items of 2405 documents
Intelligent agents for feature modelling in computer aided design
2017
Abstract CAD modelling can be referred to as the process of generating an integrated multiple view model as a representation of multiple views of engineering design. In many situations, a change in the model of one view may conflict with the models of other views. In such situations, the model of some views needs to be adapted in order to make all models consistent. Thus, CAD models should be capable of adapting themselves to new situations. Recently, agent based technologies have been considered in order to increase both knowledge level and intelligence of real and virtual objects. The contribution of this paper consists in introducing the intelligent agents in intelligent CAD modelling. T…
Enriching standards-based digital thread by fusing as-designed and as-inspected data using knowledge graphs
2020
Abstract Realizing the digital thread is essential for linking and orchestrating data across the product lifecycle in smart manufacturing. Linking heterogeneous lifecycle data is critical to maintain associativity and traceability in a digital thread. Recently, researchers have successfully leveraged ontology models with knowledge graphs in engineering domains for threading different lifecycle data. One of the most successful of such efforts is OntoSTEP which enables the formal capture of information embedded in the STandard for Exchange of Product model data (STEP) data representation, or ISO 10303. Meanwhile, an emerging inspection standard, called the Quality Information Framework (QIF),…
Introduction to Spreadsheet Modeling and Metaheuristics
2017
Models, as a simplified representation of reality, are used daily in an attempt to control or understand some aspects of a real system. Simplification of reality is the accepted view of the modeling process, which assumes that reality represents the absolute truth. Without getting too deep into a philosophical discourse, it is worth mentioning the notion of model-dependent realism, a phrase coined by physicists Stephen Hawkings and Leonard Molinow in their book The Grand Design. Model-dependent realism “is based on the idea that our brains interpret the input from our sensory organs by making a model of the world to aid in the decision-making process.” This implies that more than one model …
The ‘Open Garden of Politics’: The impact of open primaries for candidate selection in the British Conservative Party
2016
International audience; Since 2003, hundreds of open primaries for the selection of parliamentary candidates have been held by the British Conservative Party as a means of democratising party organisation and enhancing representativeness. In the run-up to the 2015 general election, only 26 primaries could be identified. This article will apply the analytical framework provided by Hazan and Rahat to demonstrate that the relative failure of the experiment in terms of intra-party competition, participation, representation and responsiveness is counterbalanced by the benefits brought by this procedure, both as a tool of party branding at the national level and as a strategy for raising the prof…
Visualization of Simulated Arrhythmias due to Gap Junctions
2018
New computational models are able to simulate details of cardiac cell networks. Their results allow a better understanding of the functionality of the heart and suggest possible actions to reduce non-fatal premature beats that can give rise to serious diseases. We developed a user-friendly interface to organize Neuron simulations and to present in real-time a three-dimensional representation of the electrical activity due to the gap junctions which interconnect the cells inside cardiac tissues. All physiological parameters were set according to real experimental observations and compared against different types of arrhythmias, retrieved from the Physionet Data Base.
Consequence of Histoincompatibility beyond GvH-Reaction in Cytomegalovirus Disease Associated with Allogeneic Hematopoietic Cell Transplantation: Cha…
2021
Hematopoietic cell (HC) transplantation (HCT) is the last resort to cure hematopoietic malignancies that are refractory to standard therapies. Hematoablative treatment aims at wiping out tumor cells as completely as possible to avoid leukemia/lymphoma relapse. This treatment inevitably co-depletes cells of hematopoietic cell lineages, including differentiated cells that constitute the immune system. HCT reconstitutes hematopoiesis and thus, eventually, also antiviral effector cells. In cases of an unrelated donor, that is, in allogeneic HCT, HLA-matching is performed to minimize the risk of graft-versus-host reaction and disease (GvHR/D), but a mismatch in minor histocompatibility antigens …
Exploring the human microbiome from multiple perspectives: factors altering its composition and function
2017
Abstract Our microbiota presents peculiarities and characteristics that may be altered by multiple factors. The degree and consequences of these alterations depend on the nature, strength and duration of the perturbations as well as the structure and stability of each microbiota. The aim of this review is to sketch a very broad picture of the factors commonly influencing different body sites, and which have been associated with alterations in the human microbiota in terms of composition and function. To do so, first, a graphical representation of bacterial, fungal and archaeal genera reveals possible associations among genera affected by different factors. Then, the revision of sequence-bas…
Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4.
2017
The T helper 9 (Th9) cell transcriptional network is formed by an equilibrium of signals induced by cytokines and antigen presentation. Here we show that, within this network, two interferon regulatory factors (IRF), IRF1 and IRF4, display opposing effects on Th9 differentiation. IRF4 dose-dependently promotes, whereas IRF1 inhibits, IL-9 production. Likewise, IRF1 inhibits IL-9 production by human Th9 cells. IRF1 counteracts IRF4-driven Il9 promoter activity, and IRF1 and IRF4 have opposing function on activating histone modifications, thus modulating RNA polymerase II recruitment. IRF1 occupancy correlates with decreased IRF4 abundance, suggesting an IRF1-IRF4-binding competition at the I…
Cancer Acidity and Hypertonicity Contribute to Dysfunction of Tumor-Associated Dendritic Cells: Potential Impact on Antigen Cross-Presentation Machin…
2020
Macrophages (M) and dendritic cells (DC), major players of the mononuclear phagocyte system (MoPh), are potent antigen presenting cells that steadily sense and respond to signals from the surrounding microenvironment, leading to either immunogenic or tolerogenic outcomes. Next to classical MHC-I/MHC-II antigen-presentation pathways described in the vast majority of cell types, a subset of MoPh (CD8+, XCR1+, CLEC9A+, BDCA3+ conventional DCs in human) is endowed with a high competence to cross-present external (engulfed) antigens on MHC-I molecules to CD8+ T-cells. This exceptional DC function is thought to be a crucial crossroad in cytotoxic antitumor immunity and has been extensively studie…
Applying Conceptual Modeling to Better Understand the Human Genome
2016
The objective of the work is to present the benefits of the application of Conceptual Modeling (CM) in complex domains, such as genomics. This paper explains the evolution of a Conceptual Schema of the Human Genome (CSHG), which seeks to provide a clear and precise understanding of the human genome. We want to highlighting all the advantages of the application of CM in a complex domain such as Genomic Information Systems (GeIS). We show how over time this model has evolved, thus we have discovered better forms of representation. As we advanced in exploring the domain, we understood that we should be extending and incorporating the new concepts detected into our model. Here we present and di…