Search results for "Presentation"

Inhibition of CD1 antigen presentation by human cytomegalovirus.

2008

ABSTRACTThe betaherpesvirus human cytomegalovirus (HCMV) encodes several molecules that block antigen presentation by the major histocompatibility complex (MHC) proteins. Humans also possess one other family of antigen-presenting molecules, the CD1 family; however, the effect of HCMV on CD1 expression is unknown. The majority of CD1 molecules are classified on the basis of homology as group 1 CD1 and are present almost exclusively on professional antigen-presenting cells such as dendritic cells, which are a major target for HCMV infection and latency. We have determined that HCMV encodes multiple blocking strategies targeting group 1 CD1 molecules. CD1 transcription is strongly inhibited by…

Suppression of CD8+ T cell recognition in the immediate-early phase of human cytomegalovirus infection.

2012

Human cytomegalovirus (HCMV) interferes with MHC class I-restricted antigen presentation and thereby reduces recognition by CD8+ T-cells. This interference is mediated primarily by endoplasmic reticulum-resident glycoproteins that are encoded in the US2–11 region of the viral genome. Such a suppression of recognition would be of particular importance immediately after infection, because several immunodominant viral antigens are already present in the cell in this phase. However, which of the evasion proteins gpUS2–11 interfere(s) with antigen presentation to CD8+ T-cells at this time of infection is not known. Here we address this question, using recombinant viruses (RV) that express only o…

Immune evasion proteins gpUS2 and gpUS11 of human cytomegalovirus incompletely protect infected cells from CD8 T cell recognition

2009

AbstractHuman cytomegalovirus (HCMV) encodes four glycoproteins, termed gpUS2, gpUS3, gpUS6 and gpUS11 that interfere with MHC class I biosynthesis and antigen presentation. Despite gpUS2–11 expression, however, HCMV infection is efficiently controlled by cytolytic CD8 T lymphocytes (CTL). To address the role of gpUS2 and gpUS11 in antigen presentation during viral infection, HCMV mutants were generated that expressed either gpUS2 or gpUS11 alone without coexpression of the three other proteins. Fibroblasts infected with these viruses showed reduced HLA-A2 and HLA-B7 surface expression. Surprisingly, however, CTL directed against the tegument protein pp65 and the regulatory IE1 protein stil…

Intention recognition in manufacturing applications

2015

In this article, we present a novel approach to intention recognition, based on the recognition and representation of state information in a cooperative human-robot environment. States are represented by a combination of spatial relations along with cardinal direction information. The output of the Intention Recognition Algorithms will allow a robot to help a human perform a perceived operation or, minimally, not cause an unsafe situation to occur. We compare the results of the Intention Recognition Algorithms to those of an experiment involving human subjects attempting to recognize the same intentions in a manufacturing kitting domain. In almost every case, results show that the Intention…

Memes y Políticas de Identidad. El poder de la risa en la cultura digital

2020

Una de las formas más arcaicas y evidentes de la comunicación es reír. En la cultura digital, las imágenes humorísticas, en concreto las satíricas, se unen a la sociedad de masas mediante la configuración de ideas e identidades. Durante el s. XIX, la identidad y el nacionalismo han sido dos caras de la misma moneda. Su representación por medio de símbolos e ideas siguen estando patentes en la actualidad. En el ámbito nacional, la identidad catalana no solo sigue teniendo una vinculación nacionalista propia del XIX, sino que ha devenido en un fenómeno de identidad propio unido asimismo al procés de independencia. Por eso mismo y con el objetivo de poner en relieve el poder de las imágenes hu…

Baltic Journal of English Language, Literature and Culture, N 6

2016

On the irreducibility of Hurwitz spaces of coverings with an arbitrary number of special points

2013

In this paper we study Hurwitz spaces of coverings of Y with an arbitrary number of special points and with monodromy group a Weyl group of type D_d, where Y is a smooth, complex projective curve. We give conditions for which these spaces are irreducible.

A Hybrid Neural Network Architecture for Dynamic Scene Understanding

1997

A hyprdid (neural and symbolic) architecture allowing for a deep understanding of moving scenes is described. The architecture is based on a working and effective integration among three levels of representation of data coming out from external sensors.

Identification of transcripts of the T cell antigen receptor beta chain gene and major histocompatibility complex class II genes in antigen-presentin…

1988

The cloned murine cell line BK-BI-2.6.C6 has previously been shown to exhibit T cell characteristics, to synthesize and express MHC class II molecules, and to present protein antigens to antigen-dependent T cell clones. As a more definitive proof of the T-cell nature of these cells, transcripts of the rearranged T cell antigen receptor (TcR) beta gene were assessed by Northern blot analysis. BK-BI-2.6.C6 cells constitutively transcribe mRNA for the light chain of TcR and express the disulphide-linked alpha, beta TcR heterodimer at the cell surface. In addition mRNA for the polymorphic MHC class II subunits A alpha and A beta as well as for the invariant gamma chain were detected. BK-BI-2.6.…

Hypergraph imaging: an overview

2002

Hypergraph theory as originally developed by Berge (Hypergraphe, Dunod, Paris, 1987) is a theory of finite combinatorial sets, modeling lot of problems of operational research and combinatorial optimization. This framework turns out to be very interesting for many other applications, in particular for computer vision. In this paper, we are going to survey the relationship between combinatorial sets and image processing. More precisely, we propose an overview of different applications from image hypergraph models to image analysis. It mainly focuses on the combinatorial representation of an image and shows the effectiveness of this approach to low level image processing; in particular to seg…